DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8728 and Pmpcb

DIOPT Version :9

Sequence 1:	NP_610333.1	Gene:	CG8728 / 35748	FlyBaseID:	FBgn0033235	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_082707.1	Gene:	Pmpcb / 73078	MGIID:	1920328	Length:	489	Species:	Mus musculus

Alignment Length:	530	Identity:	147/530 - (27%)
Similarity:	240/530 - (45%)	Gaps:	72/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RHTW---RTFP-RLMATKVTSLGGDEVGSGTGIGQITGGVRTSDGPQKVNTPSKEIVTHLPPLTE 74
            |..|   |..| |..|.:....|||.:.|            |...||.|
Mouse    16 RRLWGFTRRLPLRRAAAQPLYFGGDRLRS------------TQAAPQVV---------------- 52

  Fly    75 PLPNLPEAVYAAPLAESAITKVTTLPNGLRIASEPRYGQFCTVGLVIDSGPRYEVAYPSGVSHFL 139
              .|:||            |:||.|.||||:|||......|||||.||:|.|||....:|.:|||
Mouse    53 --LNVPE------------TQVTCLENGLRVASENSGLSTCTVGLWIDAGSRYENEKNNGTAHFL 103

  Fly   140 EKLAFNSTVNFPNKDAILKELEKNGGICDCQSSRDTLIYAASIDSRAIDSVTRLLADVTLRPTLS 204
            |.:||..|......|..| |:|..|...:..:||:..:|.|...||.:.....:|||:....||.
Mouse   104 EHMAFKGTKKRSQLDLEL-EIENMGAHLNAYTSREQTVYYAKAFSRDLPRAVEILADIIQNSTLG 167

  Fly   205 DQEVSLARRAVNFELETLGMRPEQEPILMDMIHAAAFRDNTLGLPKLCPLENLDHINRNVLMNYL 269
            :.|:...|..:..|::.  :....:.::.|.:||.|:::..||...|.|.||:..|||..|::|:
Mouse   168 EAEIERERGVILREMQE--VETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSINRKDLVDYI 230

  Fly   270 KYHHSPKRMVIAGV-GVDHDELVSHVQRYFVEDKAIWETEALEDSGPKQVDTSIAQYTGGLVKEQ 333
            ..|:...|:|:|.. ||.|:||: .:.::...|.......|:....|       .::||..::.:
Mouse   231 TTHYKGPRIVLAAAGGVCHNELL-ELAKFHFGDSLCSHKGAIPALPP-------CKFTGSEIRVR 287

  Fly   334 CEIPIYAAAGLPELAHVILGFEGCSHQDKDFVPLCVLNIMMGG-GGSFSAGGPGKGMYSRLYTKV 397
            .:       .:| |||:.:..|.......|.:.|.|.|.::|. ..||   |.|..:.|:| .::
Mouse   288 DD-------KMP-LAHLAIAVEAVGWAHPDTICLMVANTLIGNWDRSF---GGGMNLSSKL-AQL 340

  Fly   398 LNRYHWMYSATAYNHAYGDCGLFCVHGSAPPQHMNDMVEVLTREMMGMAAEPGREELMRSKIQLQ 462
            ....:..:|..::|.:|.|.||:.::.......:.||:.|:..|...:..:....|:.|:|..|:
Mouse   341 TCHGNLCHSFQSFNTSYTDTGLWGLYMVCEQATVADMLHVVQNEWKRLCTDVTESEVARAKNLLK 405

  Fly   463 SMLLMNLESRPVVFEDVGRQVLVTGQRKRPQHFIKEIESVTAADIQRVAQRLL-SSPPSVAARGD 526
            :.:|:.|:....:.||:|||:|...:|.........|::|.|..::||..:.: ...|::||.|.
Mouse   406 TNMLLQLDGSTPICEDIGRQMLCYNRRIPIPELEARIDAVDAETVRRVCTKYIHDKSPAIAALGP 470

  Fly   527 IHNLPEMSHI 536
            |..||:.:.|
Mouse   471 IERLPDFNQI 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8728	NP_610333.1	PqqL	76..532	CDD:223685	131/458 (29%)
		Peptidase_M16	104..253	CDD:279066	49/148 (33%)
		Peptidase_M16_C	259..461	CDD:282978	48/203 (24%)
Pmpcb	NP_082707.1	PqqL	46..478	CDD:223685	135/484 (28%)
		Peptidase_M16	68..215	CDD:279066	49/149 (33%)
		Peptidase_M16_C	220..404	CDD:282978	48/203 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810