DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8728 and pmpca

DIOPT Version :9

Sequence 1:	NP_610333.1	Gene:	CG8728 / 35748	FlyBaseID:	FBgn0033235	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001007443.1	Gene:	pmpca / 492801	ZFINID:	ZDB-GENE-030131-5809	Length:	517	Species:	Danio rerio

Alignment Length:	490	Identity:	254/490 - (51%)
Similarity:	356/490 - (72%)	Gaps:	13/490 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LTEPLPNLPEAVYAAPLA-ESAITKVTTLPNGLRIASEPRYGQFCTVGLVIDSGPRYEVAYPSGV 135
            |:.|||.:|:.|:|:... |...||:|||.|||:|||:.::|||||||::::||.|:|..||||:
Zfish    36 LSTPLPGIPKPVFASVDGHEKYETKITTLENGLKIASQNKFGQFCTVGILVNSGSRHEAKYPSGI 100

  Fly   136 SHFLEKLAFNSTVNFPNKDAILKELEKNGGICDCQSSRDTLIYAASIDSRAIDSVTRLLADVTLR 200
            :||||||:|:||..|.:|..||..|||:|||||||:||||.:||.|.:.:.:|:|..||:|..|:
Zfish   101 AHFLEKLSFSSTAQFGSKGEILLTLEKHGGICDCQTSRDTTMYAVSAEVKGLDTVVHLLSDAVLQ 165

  Fly   201 PTLSDQEVSLARRAVNFELETLGMRPEQEPILMDMIHAAAFRDNTLGLPKLCPLENLDHINRNVL 265
            |.|.|:|:.:||.||.||||.|.|||:.||:|.:||||||:|.||:|||:..|.:|::.|::.:|
Zfish   166 PRLLDEEIEMARMAVRFELEDLNMRPDPEPLLTEMIHAAAYRGNTVGLPRFSPADNVEKIDKKLL 230

  Fly   266 MNYLKYHHSPKRMVIAGVGVDHDELVSHVQRYFVEDKAIWETEALEDSGPKQVDTSIAQYTGG-- 328
            ..||:.::.|:|||:||||::|::||...::|.:..:.:|     .:|.|..||.|:||||||
Zfish   231 HKYLQSYYCPERMVLAGVGIEHEQLVQCARKYLLNVQPVW-----GESKPANVDRSVAQYTGGIV 290

  Fly   329 -LVKEQCEIPIYAAAGLPELAHVILGFEGCSHQDKDFVPLCVLNIMMGGGGSFSAGGPGKGMYSR 392
             :||:..::.: ....:|||.|:::|.|.||..::||:|..|||:|||||||||||||||||::|
Zfish   291 KMVKDMSDVSL-GPTPIPELTHIMIGLESCSFLEEDFIPFAVLNMMMGGGGSFSAGGPGKGMFTR 354

  Fly   393 LYTKVLNRYHWMYSATAYNHAYGDCGLFCVHGSAPPQHMNDMVEVLTREMMGMAAEPGREELMRS 457
            ||..||||:||||:||:|:|:|.|.||.|:|.||.|:.:.:|||::|||.:.|....|..||.|:
Zfish   355 LYLNVLNRHHWMYNATSYHHSYEDSGLLCIHASADPRQVREMVEIITREFIQMTGTAGEMELERA 419

  Fly   458 KIQLQSMLLMNLESRPVVFEDVGRQVLVTGQRKRPQHFIKEIESVTAADIQRVAQRLLSSPPSVA 522
            |.||:|||:||||||||:|||||||||.||:||.|....:.|.:|||:||:||..::|.|.|:||
Zfish   420 KTQLKSMLMMNLESRPVIFEDVGRQVLATGKRKLPHELCELISTVTASDIKRVTMKMLRSKPAVA 484

  Fly   523 ARGDIHNLPEMSHITNAVSG-SGRTGLGRRLSLFK 556
            |.||:..||....|..|:|. .||  |.|...||:
Zfish   485 ALGDLTELPSYEDIQAALSSKDGR--LPRIYRLFR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8728	NP_610333.1	PqqL	76..532	CDD:223685	242/459 (53%)
		Peptidase_M16	104..253	CDD:279066	85/148 (57%)
		Peptidase_M16_C	259..461	CDD:282978	97/204 (48%)
pmpca	NP_001007443.1	PqqL	59..496	CDD:223685	237/442 (54%)
		Peptidase_M16	69..218	CDD:279066	85/148 (57%)
		Peptidase_M16_C	224..423	CDD:282978	97/204 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592405
Domainoid	1	1.000	217	1.000	Domainoid score	I2623
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6078
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1223
OMA	1	1.010	-	-		QHG53769
OrthoDB	1	1.010	-	-		D427789at33208
OrthoFinder	1	1.000	-	-		FOG0003938
OrthoInspector	1	1.000	-	-		oto38678
orthoMCL	1	0.900	-	-		OOG6_102381
Panther	1	1.100	-	-	LDO	PTHR11851
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2236
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910