DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8728 and Nrd1

DIOPT Version :9

Sequence 1:	NP_610333.1	Gene:	CG8728 / 35748	FlyBaseID:	FBgn0033235	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_572757.2	Gene:	Nrd1 / 32143	FlyBaseID:	FBgn0030344	Length:	1147	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	118/562 - (20%)
Similarity:	201/562 - (35%)	Gaps:	120/562 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 HTWRTFPRLMATK----VTSLGGDEVGSGTGIGQITGGVRTSDGPQKVNTPSKEIVT-------H 68
            |.:|.|...:.||    :|.|.|....:.:.:.::|..|:..|.|.|..|..|...|       |
  Fly     9 HLFRRFEFHVRTKRRSPITQLAGVRAITYSSLCKMTDQVKYLDIPDKSETDKKLYKTLLLGNGLH 73

  Fly    69 LPPLTEPLPNLPEAVYAAPLAESAITKVTTLPNGLRI-------------------ASEPRYGQF 114
            ...:::|.| :|...:..  :||:.:|.|...:...|                   :||....:.
  Fly    74 ALIVSDPSP-MPHDGFTT--SESSSSKSTVSTSSSIISRSESTSSTSTDSESSEESSSEEGDEKL 135

  Fly   115 CTVGLVIDSGPRYEVAYPSGVSHFLEKLAFNSTVNFPNKDAILKELEKNGGIC----DCQSSRDT 175
            ....|:||.|...|.....|::||||.:.|..:..:|.::.....::|.||..    ||:   ||
  Fly   136 AACALLIDYGSFAEPTKYQGLAHFLEHMIFMGSEKYPKENIFDAHIKKCGGFANANTDCE---DT 197

  Fly   176 LIYAASIDSRAIDSVTRLLADVTLRPTLSDQEVSLARRAVNFELETLGMRPE-QEPILMDMIHAA 239
            |.| ..:..:.:||.......:...|.:..:.:...|.||:.|.:.:....| :...|:..:...
  Fly   198 LFY-FEVAEKHLDSSLDYFTALMKAPLMKQEAMQRERSAVDSEFQQILQDDETRRDQLLASLATK 261

  Fly   240 AFRDNTLGLPKLCPL-ENLDHIN-RNVLMNYLKYHHSPKRM-VIAGVGVDHDELVSHVQRYFVED 301
            .|...|.....:..| ||:|... ..:|....|.|:...|| |.....:..|||.|.|.|:|
  Fly   262 GFPHGTFAWGNMKSLKENVDDAELHKILHEIRKEHYGANRMYVCLQARLPIDELESLVVRHF--- 323

  Fly   302 KAIWETEALEDSGPKQVDTSIAQYTGGL-------------VKEQCEIPI---------YAAAGL 344
                  ..:..:..|..|.|...|....             |:.:.::.:         |..:..
  Fly   324 ------SGIPHNEVKAPDLSSFNYKDAFKAEFHEQVFFVKPVENETKLELTWVLPNVRQYYRSKP 382

  Fly   345 PELAHVILGFEG----CSHQDKDFVPLCVLNIMMGGGGSFSAGGPGKGMYS------RLYTKVLN 399
            .:....:||:||    |::..:....|.::      .|....|.....|||      .|..:...
  Fly   383 DQFLSYLLGYEGRGSLCAYLRRRLWALQLI------AGIDENGFDMNSMYSLFNICIYLTDEGFK 441

  Fly   400 RYHWMYSAT-AYNHAYGDCGLFCVHGSAPPQHMNDMVEVLTREMMGMAAEPG-REELMRSKIQLQ 462
            ....:.:|| ||...:.:||           .|.|:.|...|.     .|.| |....|......
  Fly   442 NLDEVLAATFAYVKLFANCG-----------SMKDVYEEQQRN-----EETGFRFHAQRPAFDNV 490

  Fly   463 SMLLMNLESRPVVFEDVGRQVLVTGQR---KRPQHFIKEIES 501
            ..|::||:..|.  :|:     :||:.   :..:..:||:.|
  Fly   491 QELVLNLKYFPP--KDI-----LTGKELYYEYNEEHLKELIS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8728	NP_610333.1	PqqL	76..532	CDD:223685	100/490 (20%)
		Peptidase_M16	104..253	CDD:279066	35/172 (20%)
		Peptidase_M16_C	259..461	CDD:282978	45/237 (19%)
Nrd1	NP_572757.2	Ptr	54..1023	CDD:223956	106/517 (21%)
		Peptidase_M16	136..246	CDD:279066	28/113 (25%)
		Peptidase_M16_C	289..472	CDD:282978	40/208 (19%)
		Peptidase_M16_M	478..766	CDD:292805	12/55 (22%)
		Peptidase_M16_C	769..953	CDD:282978
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445072
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840