Protein Alignment CG8728 and PMPCA

DIOPT Version :10

• Sequence 1: NP_610333.1
• Gene: CG8728 / 35748
• FlyBaseID: FBgn0033235
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: XP_005266116.1
• Gene: PMPCA / 23203
• HGNCID: 18667
• Length: 563
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 260/549 - (47%)
• Similarity: 355/549 - (64%)
• Gaps: 50/549 - (9%)

  Fly    23 LMATKVTSLGGDEVGSGT-GIGQITGGV----RTSDGPQKVNTPSKEIVTHLPPLTEPLPNLPEA 82
            |.||::..      |||: |..::..|.    |.|.|....|.          ||:.|||.:|:.
Human     6 LAATRLLR------GSGSWGCSRLRFGPPAYRRFSSGGAYPNI----------PLSSPLPGVPKP 54

  Fly    83 VYAAPLAESAI-TKVTTLPNGLRIASEPRYGQFCTVGLVIDSGPRYEVAYPSGVSHFLEKLAFNS 146
            |:|....:... ||||||.||||:||:.::|||||||::|:||.|||..|.||::||||||||:|
Human    55 VFATVDGQEKFETKVTTLDNGLRVASQNKFGQFCTVGILINSGSRYEAKYLSGIAHFLEKLAFSS 119

  Fly   147 TVNFPNKDAILKELEKNGGICDCQSSRDTLIYAASIDSRAIDSVTRLLADVTLRPTLSDQEVSLA 211
            |..|.:||.||..|||:|||||||:||||.:||.|.||:.:|:|..|||||.|:|.|:|:||.:.
Human   120 TARFDSKDEILLTLEKHGGICDCQTSRDTTMYAVSADSKGLDTVVALLADVVLQPRLTDEEVEMT 184

  Fly   212 RRAVNFELETLGMRPEQEPILMDMIHAAAFRDNTLGLPKLCPLENLDHINRNVLMNYLKYHHSPK 276
            |.||.||||.|.:||:.||:|.:|||.||:|:||:||.:.||.||:..|||.||.:||:.:::|.
Human   185 RMAVQFELEDLNLRPDPEPLLTEMIHEAAYRENTVGLHRFCPTENVAKINREVLHSYLRNYYTPD 249

  Fly   277 RMVIAGVGVDHDELVSHVQRYFVEDKAIW-ETEALEDSGPKQVDTSIAQYTGGLVKEQCEI---- 336
            |||:|||||:|:.||...::|.:..:..| ..||::      :|.|:||||||:.|.:.::
Human   250 RMVLAGVGVEHEHLVDCARKYLLGVQPAWGSAEAVD------IDRSVAQYTGGIAKLERDMSNVS 308

  Fly   337 ----PIYAAAGLPELAHVILGFEGCSHQDKDFVPLCVLNIMMGGGGSFSAGGPGKGMYSRLYTKV 397
                ||      |||.|:::|.|.||..::||:|..|||:|||||||||||||||||:||||..|
Human   309 LGPTPI------PELTHIMVGLESCSFLEEDFIPFAVLNMMMGGGGSFSAGGPGKGMFSRLYLNV 367

  Fly   398 LNRYHWMYSATAYNHAYGDCGLFCVHGSAPPQHMNDMVEVLTREMMGMAAEPGREELMRSKIQLQ 462
            |||:||||:||:|:|:|.|.||.|:|.||.|:.:.:|||::|:|.:.|.......||.|:|.||.
Human   368 LNRHHWMYNATSYHHSYEDTGLLCIHASADPRQVREMVEIITKEFILMGGTVDTVELERAKTQLT 432

  Fly   463 SMLLMNLESRPVVFEDVGRQVLVTGQRKRPQHFIKEIESVT--AADIQRVAQRL----LSSPPSV 521
            |||:||||||||:|||||||||.|..||.|......|....  :..:.:.:.||    |:.|.:|
Human   433 SMLMMNLESRPVIFEDVGRQVLATRSRKLPHELCTLIREYRRGSEGLPQASARLRGGRLALPQAV 497

  Fly   522 AARGDIHNLPEMSHITNAVSGSGRTGLGR 550
            .....:|:...:......:|..|: |.||
Human   498 VGLWYVHHTQNLGPSPVVLSRGGQ-GQGR 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8728	NP_610333.1	PqqL	79..521	CDD:440377	236/457 (52%)
PMPCA	XP_005266116.1	PqqL	62..441	CDD:440377	210/390 (54%)