Protein Alignment drosha and RNT1

DIOPT Version :10

• Sequence 1: NP_477436.1
• Gene: drosha / 35747
• FlyBaseID: FBgn0026722
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_013966.1
• Gene: RNT1 / 855280
• SGDID: S000004852
• Length: 471
• Species: Saccharomyces cerevisiae
• Alignment Length: 527
• Identity: 124/527 - (23%)
• Similarity: 206/527 - (39%)
• Gaps: 138/527 - (26%)

  Fly   782 NSLTNCGIRQPEYGDRKIHYMNTRKRGINTLVSIMSRFGKEHETVSNITHNERLEFLGDAVVEFL 846
            |.|.|      |.|.::...:||:     ||:       |.:..:||..:.|.:: |..||.:.:
Yeast    15 NKLDN------ENGSQQRENINTK-----TLL-------KGNLKISNYKYLEVIQ-LEHAVTKLV 60

  Fly   847 SSIHLFFMFPELEEGGLATYRAAIVQNQHLALLAKKLQLEEFMLYAHGSDLCHELELRHAM---- 907
            .|.:...   ||.. .|..|..| |.||....:.....|..:.|     .|..||:..|.:
Yeast    61 ESYNKII---ELSP-NLVAYNEA-VNNQDRVPVQILPSLSRYQL-----KLAAELKTLHDLKKDA 115

  Fly   908 --------ANCFEALMGALLLDGGIKVAD----EVFTDALFRQDEKL-LSIWKNLPEHPLQEQEP 959
                    .|.|:......:|. .|..||    |........:.||: :::::||.|.. .|:|.
Yeast   116 ILTEITDYENEFDTEQKQPILQ-EISKADMEKLEKLEQVKREKREKIDVNVYENLNEKE-DEEED 178

  Fly   960 LGDRSCIDSYRVLK-----ELTKFEDSIGIKFKHIRLLARAFTDRS-------IGFTHLTLGSNQ 1012
            .|:    |||...|     :.||:...:. :.:.:.:.||.|..:|       :..:.:....|:
Yeast   179 EGE----DSYDPTKAGDIVKATKWPPKLP-EIQDLAIRARVFIHKSTIKDKVYLSGSEMINAHNE 238

  Fly  1013 RLEFLGDTVLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANPKADL 1077
            |||||||::|..:.:..:|..||::.||.||.||.:||:|..         :.::::..|....|
Yeast   239 RLEFLGDSILNSVMTLIIYNKFPDYSEGQLSTLRMNLVSNEQ---------IKQWSIMYNFHEKL 294

  Fly  1078 KT----KDR------------ADLLEAFLGALYVD---KGLLYCEQFCHVCLFP------RLQLF 1117
            ||    ||.            ||:.||::|.|..|   ..|....::......|      |.|:.
Yeast   295 KTNFDLKDENSNFQNGKLKLYADVFEAYIGGLMEDDPRNNLPKIRKWLRKLAKPVIEEATRNQVA 359

  Fly  1118 IMNQDWNDPKSKLQQCCL----TLRTMDGGEPDIPYYKV-----VEASGPTNTRVYKVAVYFRSK 1173
            :...|..|..:|.|...|    :||        :.|..|     |:.:.....||....|
Yeast   360 LEKTDKLDMNAKRQLYSLIGYASLR--------LHYVTVKKPTAVDPNSIVECRVGDGTV----- 411

  Fly  1174 RLATSSGSSIQQAEMNAAKQALENSR--DLFPQLDHQKRVIAKSIKKQTGNELDNDSDRQHQEEK 1236
             |.|..|.:|:.|.:.||:.||.:.:  |.:.:   |:..|.:|           :|..:...:|
Yeast   412 -LGTGVGRNIKIAGIRAAENALRDKKMLDFYAK---QRAAIPRS-----------ESVLKDPSQK 461

  Fly  1237 IKRPKYA 1243
            .|:.|::
Yeast   462 NKKRKFS 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	RIBOc	826..942	CDD:197778	29/131 (22%)
		Rnc	973..1196	CDD:440336	66/268 (25%)
RNT1	NP_013966.1	RNase_3_N	44..147	CDD:436545	25/114 (22%)
		RIBOc	207..354	CDD:238333	40/155 (26%)
		DSRM_RNT1p-like	367..436	CDD:380705	21/82 (26%)