DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drosha and MRPL3

DIOPT Version :9

Sequence 1:	NP_477436.1	Gene:	drosha / 35747	FlyBaseID:	FBgn0026722	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_013737.1	Gene:	MRPL3 / 855039	SGDID:	S000004626	Length:	390	Species:	Saccharomyces cerevisiae

Alignment Length:	425	Identity:	85/425 - (20%)
Similarity:	147/425 - (34%)	Gaps:	147/425 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   817 SRF-GKEHETVSNITHNERLEFLGDAVVEFLSSIHLFFMFPELEEGGLATYR------------- 867
            ||| .|.:..:|.:|..|:         .||         ||.|   ||.|:
Yeast    44 SRFTSKRYLHLSTLTQQEK---------RFL---------PESE---LAKYKEYYQGLKSTVNEI 87

  Fly   868 --AAIVQNQHLALLAKKLQLEEFMLYA---------------------HGSDLCHELELRHAMAN 909
              :...::..|..|.|:|||...:.|:                     .|:...:.:.....:.|
Yeast    88 PESVASKSPSLRTLHKRLQLPNELTYSTLSRCLTCPSAKLPDKINNPTKGAAFVNTVPTNKYLDN 152

  Fly   910 CFEALMGALLLDGGIKVADEVFTDALFRQDEKLLSIWKNLPEHPLQEQEPLGDRSCIDSY---RV 971
            ....:||..||.              :...:.::..:..||...|        .:.:::|   .|
Yeast   153 HGLNIMGKNLLS--------------YHVTKSIIQKYPRLPTVVL--------NAAVNAYISEAV 195

  Fly   972 LKELTKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTV-----LQLICSEYLY 1031
            |..:.|:   .||:.:...:|:|........|   |||   ||:|..:::     ::||..
Yeast   196 LAHIAKY---WGIEVETTSVLSRYLKMEPFEF---TLG---RLKFFNNSLNSKDGIELITG---- 247

  Fly  1032 RHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANPKADLKTKDRADLLEAFLGALYVD 1096
            ::|.|                 |.|     |.|...::.|...|..:.||...:..      ::|
Yeast   248 KNFSE-----------------TSA-----LAMSVRSIIAAIWAVTEQKDSQAVYR------FID 284

  Fly  1097 KGLLYCEQFCHVCLFPRLQLFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGP-TN 1160
            .         |: :..:|.:..|.| :..|..:|...|    ..:|.|.  |..|:|..||. :.
Yeast   285 D---------HI-MSRKLDITKMFQ-FEQPTRELAMLC----RREGLEK--PVSKLVAESGRLSK 332

  Fly  1161 TRVYKVAVYFRSKRLATSSGSSIQQAEMNAAKQAL 1195
            :.|:.|.|:...:.|....|||:::|:..||..||
Yeast   333 SPVFIVHVFSGEETLGEGYGSSLKEAKARAATDAL 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	DLL_N	64..136	CDD:289198
		Rnc	738..>974	CDD:223644	34/196 (17%)
		RIBOc	826..942	CDD:197778	24/151 (16%)
		rnc	973..1196	CDD:234633	51/229 (22%)
		RIBOc	990..1117	CDD:197778	24/131 (18%)
		DSRM	1125..1196	CDD:238007	22/72 (31%)
MRPL3	NP_013737.1	Rnc	114..376	CDD:223644	63/334 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900