Protein Alignment drosha and MRPL3

DIOPT Version :10

• Sequence 1: NP_477436.1
• Gene: drosha / 35747
• FlyBaseID: FBgn0026722
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_013737.1
• Gene: MRPL3 / 855039
• SGDID: S000004626
• Length: 390
• Species: Saccharomyces cerevisiae
• Alignment Length: 425
• Identity: 85/425 - (20%)
• Similarity: 147/425 - (34%)
• Gaps: 147/425 - (34%)

  Fly   817 SRF-GKEHETVSNITHNERLEFLGDAVVEFLSSIHLFFMFPELEEGGLATYR------------- 867
            ||| .|.:..:|.:|..|:         .||         ||.|   ||.|:
Yeast    44 SRFTSKRYLHLSTLTQQEK---------RFL---------PESE---LAKYKEYYQGLKSTVNEI 87

  Fly   868 --AAIVQNQHLALLAKKLQLEEFMLYA---------------------HGSDLCHELELRHAMAN 909
              :...::..|..|.|:|||...:.|:                     .|:...:.:.....:.|
Yeast    88 PESVASKSPSLRTLHKRLQLPNELTYSTLSRCLTCPSAKLPDKINNPTKGAAFVNTVPTNKYLDN 152

  Fly   910 CFEALMGALLLDGGIKVADEVFTDALFRQDEKLLSIWKNLPEHPLQEQEPLGDRSCIDSY---RV 971
            ....:||..||.              :...:.::..:..||...|        .:.:::|   .|
Yeast   153 HGLNIMGKNLLS--------------YHVTKSIIQKYPRLPTVVL--------NAAVNAYISEAV 195

  Fly   972 LKELTKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTV-----LQLICSEYLY 1031
            |..:.|:   .||:.:...:|:|........|   |||   ||:|..:::     ::||..
Yeast   196 LAHIAKY---WGIEVETTSVLSRYLKMEPFEF---TLG---RLKFFNNSLNSKDGIELITG---- 247

  Fly  1032 RHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANPKADLKTKDRADLLEAFLGALYVD 1096
            ::|.|                 |.|     |.|...::.|...|..:.||...:..      ::|
Yeast   248 KNFSE-----------------TSA-----LAMSVRSIIAAIWAVTEQKDSQAVYR------FID 284

  Fly  1097 KGLLYCEQFCHVCLFPRLQLFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGP-TN 1160
            .         |: :..:|.:..|.| :..|..:|...|    ..:|.|.  |..|:|..||. :.
Yeast   285 D---------HI-MSRKLDITKMFQ-FEQPTRELAMLC----RREGLEK--PVSKLVAESGRLSK 332

  Fly  1161 TRVYKVAVYFRSKRLATSSGSSIQQAEMNAAKQAL 1195
            :.|:.|.|:...:.|....|||:::|:..||..||
Yeast   333 SPVFIVHVFSGEETLGEGYGSSLKEAKARAATDAL 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	RIBOc	826..942	CDD:197778	24/151 (16%)
		Rnc	973..1196	CDD:440336	51/229 (22%)
MRPL3	NP_013737.1	RIBOc	114..288	CDD:197778	38/246 (15%)
		DSRM_MRPL3_like	290..373	CDD:380702	25/85 (29%)