DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drosha and RTL3

DIOPT Version :9

Sequence 1:	NP_477436.1	Gene:	drosha / 35747	FlyBaseID:	FBgn0026722	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_199328.1	Gene:	RTL3 / 834551	AraportID:	AT5G45150	Length:	957	Species:	Arabidopsis thaliana

Alignment Length:	850	Identity:	142/850 - (16%)
Similarity:	240/850 - (28%)	Gaps:	383/850 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   742 SLDLLEESIGYRFKNRYLLQLALTHPSYKENYGTNPDHARNSLTNCGIRQPEYGDRKIHYMNTRK 806
            |::.:|:.:.|.|.|:.||:.|:|..|                       |.:
plant     3 SVEAVEKILNYSFVNKTLLKEAITQKS-----------------------PLF------------ 32

  Fly   807 RGINTLVSIMSRFGKEHETVSNITHNERLEFLGDAVVEFLSSIHLFFMFPELEEGGLATYRAAIV 871
                                      :||||.||:::|...:.::...:|.|:...|...|.|.|
plant    33 --------------------------DRLEFFGDSILEVAFTNYICHTYPNLKVKELRDLRTANV 71

  Fly   872 QNQHLALLAKKLQLEEFMLY--------------------------------------------- 891
            .|:..|.:|....|..|:|.
plant    72 SNEKFARIAVNHNLHHFLLLQNPSLFKKVKNFAEAVRKEDDPVPYGGLVKAPKILADTLESIAAT 136

  Fly   892 ---------------------------------------------AHGSDL-------------- 897
                                                         .|||:.
plant   137 VFIDVNYDVKRLWEIFRSLLEPIYTPDDLLLQPKLPFLTLFRLADKHGSESTSGIRKMTTSTKIL 201

  Fly   898 -----CHELELRHAMANCFEALMGALLLDGGIKVADEVFTDALFRQ----DE------------- 940
                 |.:::|.......||.....|.  ....|::...||.:.::    ||
plant   202 LRNKDCLDVDLEDVKGKSFEICSTELF--SLSTVSENSLTDEMSQEEVVIDEDSPNVEPEDVKGK 264

  Fly   941 -------KLLSIWKNLPEHPLQEQ---------------EPLGDRS-----C-----------ID 967
                   :.|.|......:||..:               ||:..|.     |           :.
plant   265 LFEICYTRKLQIQTGSSGNPLTYEMTTKQMVVDKDSLHVEPVNGRGELIEICTKNKWPRPIFSVQ 329

  Fly   968 SYRVLKELTKFEDSIGIKFKHIR------------------------------------------ 990
            ..:..|...||..|:.|:..:|.
plant   330 EEKGPKNEPKFVCSVKIEIPNIEGTFHMKGDIKSKKKQAENSLAYHMIRALESSLVSLVISNLQK 394

  Fly   991 ----------LLARAFTDRSI---------GFTHLTLGSN----------QRLEFLGDTVLQLIC 1026
                      ||..:..|.|:         .|.:.||...          |.|.|:|::.|.|..
plant   395 PKSLDEKNNPLLFSSEMDSSVEAVEKILNYSFVNKTLLKELLTHNNSPLFQGLMFVGESALSLAF 459

  Fly  1027 SEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANPKADLKTKD---------- 1081
            :::||..:|......||:||.:...:...|.|....|:.:..:.:.||.:..|.|
plant   460 TKHLYLTYPMLEPKDLSVLRDANTCHDKYACVAVKKGIYQSFIGSVPKPEKMTTDFIELMGKEDD 524

  Fly  1082 ----------RADLLEAFLGALYVD-----KGLLYCEQFCHVCLFPRLQLFIMNQDWNDPKSKLQ 1131
                      ..:||....||:|:|     :.||   :...|.|.|...|       :|.:.:|:
plant   525 PYRVVKAPKILVNLLAGVAGAVYIDVKYNVQRLL---EIFRVLLEPIYTL-------DDLRMQLK 579

  Fly  1132 QCCLTL-RTMD--GGEPDIPYYKVVEASGPTNTRVYKVAVYFRSKRLATSSGSSIQQAEMNAAKQ 1193
            |..|.| |..|  |.:.|..|.|    .|.:...:  ..||.....:|:.....|..|::.||::
plant   580 QPFLMLFRLADKHGKQIDFRYSK----DGGSRKNI--AQVYMDDMFIASGCAKRIDTAKLLAAEE 638

  Fly  1194 ALENSRDLFP--QLDHQKRVIAKSIKKQTGNE-----LDNDSDRQHQEEKIKRPKYATPLQDESH 1251
            |::...:..|  ::.||..:..:.|  |||:.     .:|....:..:|::        :.||..
plant   639 AIQKLSECMPIEKIIHQDNLDGEVI--QTGSSSLLTAFENPLTEEMTQEQM--------VIDEDS 693

  Fly  1252 LPKQYRMHE--------------NISSDELPEDEDFESTAPK------SPTMPLRSNRSGSSSSS 1296
            |..::::.|              .:|.:.||    .|.|..|      ||.:.|...:..|...|
plant   694 LDVEWKLFETEELQIQTGSSSMSTVSENPLP----CEITPTKMVIGEVSPHVELEDVKGKSFEIS 754

  Fly  1297 SSSDS 1301
            |:..|
plant   755 STETS 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	DLL_N	64..136	CDD:289198
		Rnc	738..>974	CDD:223644	51/395 (13%)
		RIBOc	826..942	CDD:197778	32/248 (13%)
		rnc	973..1196	CDD:234633	65/321 (20%)
		RIBOc	990..1117	CDD:197778	38/222 (17%)
		DSRM	1125..1196	CDD:238007	20/73 (27%)
RTL3	NP_199328.1	Rnc	1..>170	CDD:223644	30/227 (13%)
		RIBOc	19..165	CDD:238333	25/206 (12%)
		DSRM	307..381	CDD:294045	8/73 (11%)
		RNaseIII	419..643	CDD:274024	55/239 (23%)
		RIBOc	430..574	CDD:238333	34/153 (22%)
		dsrm	584..643	CDD:278464	16/64 (25%)
		DSRM	839..911	CDD:294045
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D935825at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820