Protein Alignment drosha and DCL3

DIOPT Version :10

• Sequence 1: NP_477436.1
• Gene: drosha / 35747
• FlyBaseID: FBgn0026722
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_001154662.2
• Gene: DCL3 / 823508
• AraportID: AT3G43920
• Length: 1580
• Species: Arabidopsis thaliana
• Alignment Length: 1305
• Identity: 256/1305 - (19%)
• Similarity: 426/1305 - (32%)
• Gaps: 491/1305 - (37%)

  Fly   208 YSPRGHHERERNET----LEKTRAKPKVETERDRLLRQWCSNFCEKPEDYVKKMNALSEADAPVE 268
            ||....|.::.|..    ||  |..||   :||.|            .|.:::...:.:.:||.
plant   504 YSQSQKHAKQSNSKSIMFLE--RGNPK---QRDHL------------HDLMRREVLIQDPEAPN- 550

  Fly   269 SWVRSSPAELYYERTKSENEVRGRARLQKLCTLFDEELLQRAKRVREKLPVYVPPPRKARRRVCK 333
              ::|.|..:     |:.:.|:....:     :..:..:..::.......:..||.|..:...||
plant   551 --LKSCPPPV-----KNGHGVKEIGSM-----VIPDSNITVSEEAASTQTMSDPPSRNEQLPPCK 603

  Fly   334 H------------KHKSEACSSSSSSDDDSDEDAFKIEQDCCMEELSRKVQHPQRVHADLWHNDA 386
            .            |.|..:..|.|||.....:...::....|...||           ..|
plant   604 KLRLDNNLLQSNGKEKVASSKSKSSSSAAGSKKRKELHGTTCANALS-----------GTW---- 653

  Fly   387 GEMNDGPLCRCSAKSRRIGIRHGIYPGETGYKLCDPNSNNAGKLFHYRISISPPTNFLTKTPTII 451
            ||..||...:                   .||. |...|.:|:::         ::|.....:.:
plant   654 GENIDGATFQ-------------------AYKF-DFCCNISGEVY---------SSFSLLLESTL 689

  Fly   452 KHDEHEFLFEGFSLLSHVRLSDLPVCKVIRFNIEYTIEYEEEKMPENFTIHELDIFFKYLFHELL 516
            ..|..:...:.:.:...|:.|..| |..||.:.|   |..:.|..:.|       ||..:|.:|
plant   690 AEDVGKVEMDLYLVRKLVKASVSP-CGQIRLSQE---ELVKAKYFQQF-------FFNGMFGKL- 742

  Fly   517 ELVDFNLMPNLPSGNVEESC----------PAFHFFPRFVRDLPDNGKEVLAMVEVLRYLLDNSA 571
                  .:.:...|...|..          |||.|..     ||....::.:...:....:::.|
plant   743 ------FVGSKSQGTKREFLLQTDTSSLWHPAFMFLL-----LPVETNDLASSATIDWSAINSCA 796

  Fly   572 QLVE---RQQLLHL-----NQISQSEWQNYVDFIKGMLVTKPGYKPCSLRVDQLDRNNSDLPECV 628
            .:||   :..||.|     ||.:.|..|..                  |..|:::..|
plant   797 SIVEFLKKNSLLDLRDSDGNQCNTSSGQEV------------------LLDDKMEETN------- 836

  Fly   629 DRETGISHPAIVHFGICHPQLSYAGNPEYQKAWREYVKYRHLMANMSKPSFKDKRKLEEKEQRLQ 693
                      ::||                             ||.|    .||..|||.
plant   837 ----------LIHF-----------------------------ANAS----SDKNSLEEL----- 853

  Fly   694 EMRTQGRMKRNITVAISSEGFYRTGIMCDVVQHAMLIPVLTGHLRFHKSLDLLEESIGYR----- 753
                       :.:||.:...|  .|:..|...:.:.|       |.     ::.|.||.
plant   854 -----------VVIAIHTGRIY--SIVEAVSDSSAMSP-------FE-----VDASSGYATYAEY 893

  Fly   754 FKNRYLLQLALTHPS-----YKENYGTNPDHARNSLTNCGIR-----QPEYGDRKIHYMNTRKR- 807
            |..:|  .:.|.||:     .|:::     ||.|.|.:....     :|:.|       |.|||
plant   894 FNKKY--GIVLAHPNQPLMKLKQSH-----HAHNLLVDFNEEMVVKTEPKAG-------NVRKRK 944

  Fly   808 -----------------------GINTLVSIMSRFG--------KEH----------------ET 825
                                   .|..|.|:|.|..        :|.                |.
plant   945 PNIHAHLPPELLARIDVPRAVLKSIYLLPSVMHRLESLMLASQLREEIDCSIDNFSISSTSILEA 1009

  Fly   826 VSNIT-----HNERLEFLGDAVVEFLSSIHLFFMFPELEEGGLATYRAAIVQNQHLALLAKKLQL 885
            |:.:|     ..||||.|||:|:::::|.|||..:|:.:||.|:..|.:|:.|.:|..|....:|
plant  1010 VTTLTCPESFSMERLELLGDSVLKYVASCHLFLKYPDKDEGQLSRQRQSIISNSNLHRLTTSRKL 1074

  Fly   886 E-----------------EFMLY----------------------------AHGSDLCHELELRH 905
            :                 :|.|:                            ....|:.|...:..
plant  1075 QGYIRNGAFEPRRWTAPGQFSLFPVPCKCGIDTREVPLDPKFFTENMTIKIGKSCDMGHRWVVSK 1139

  Fly   906 AMANCFEALMGALLLDGGIKVA---------DEVFTDALFRQDEKLLSIWKNLPEHPLQEQEPLG 961
            ::::|.|||:||..:.||:..:         |..|...|..:....:|:...:|:.
plant  1140 SVSDCAEALIGAYYVSGGLSASLHMMKWLGIDVDFDPNLVVEAINRVSLRCYIPKE--------- 1195

  Fly   962 DRSCIDSYRVLKELTKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTVLQLIC 1026
                       .||.:.|..|..:|....||..|.|..|:..::    |.:|||||||:||..:.
plant  1196 -----------DELIELERKIQHEFSAKFLLKEAITHSSLRESY----SYERLEFLGDSVLDFLI 1245

  Fly  1027 SEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVC------------------------------DD 1061
            :.:|:..:.:...|.::.|||:.|||...|.|.                              |:
plant  1246 TRHLFNTYEQTGPGEMTDLRSACVNNENFAQVAVKNNLHTHLQRCATVLETQINDYLMSFQKPDE 1310

  Fly  1062 LGMPKYAVYANPKADLKTKDRADLLEAFLGALYVDKGLLYCEQFCHV---CLFP-----RLQLFI 1118
            .|....:: ..|||      ..|::|:..|||.:|. .|..:|...|   .|.|     :|||
plant  1311 TGRSIPSI-QGPKA------LGDVVESIAGALLIDT-RLDLDQVWRVFEPLLSPLVTPDKLQL-- 1365

  Fly  1119 MNQDWNDPKSKLQQCCLTLR-------TMDGGEPDIPYYKVVEASGPTNTRVYKVAVYFRSKRLA 1176
                  .|..:|.:.|.:|.       :.||          |:|......::..|        |.
plant  1366 ------PPYRELNELCDSLGYFFRVKCSNDG----------VKAQATIQLQLDDV--------LL 1406

  Fly  1177 TSSGSSIQQAEMNAAKQALENSRDLFPQLDHQKRVIAKSIK---KQTGNELD---NDSDRQ---- 1231
            |..||  :|....|..:|..:   |..||  :||.|::...   .|:..:::   |.|||:
plant  1407 TGDGS--EQTNKLALGKAASH---LLTQL--EKRNISRKTSLGDNQSSMDVNLACNHSDRETLTS 1464

  Fly  1232 --HQEEKIKRPKYATPLQDESHLPKQYRMHENISSDELPEDEDFESTAPKSPTMPLRSNRSGSSS 1294
              .:.:.|..| :..|:..:...|:. .:||.......|. ..|:::..||.| |......|...
plant  1465 ETTEIQSIVIP-FIGPINMKKGGPRG-TLHEFCKKHLWPM-PTFDTSEEKSRT-PFEFIDGGEKR 1525

  Fly  1295 SSSSS 1299
            :|.||
plant  1526 TSFSS 1530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	RIBOc	826..942	CDD:197778	39/174 (22%)
		Rnc	973..1196	CDD:440336	65/267 (24%)
DCL3	NP_001154662.2	DEXHc_dicer	46..237	CDD:350792
		SF2_C_dicer	391..522	CDD:350189	4/17 (24%)
		PAZ_CAF_like	824..962	CDD:239210	40/249 (16%)
		RIBOc	1006..1175	CDD:238333	38/168 (23%)
		RIBOc	1214..1361	CDD:238333	41/158 (26%)
		DSRM_SF	1492..1572	CDD:444671	12/41 (29%)