DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drosha and DCL2

DIOPT Version :9

Sequence 1:NP_477436.1 Gene:drosha / 35747 FlyBaseID:FBgn0026722 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_001189798.1 Gene:DCL2 / 821300 AraportID:AT3G03300 Length:1388 Species:Arabidopsis thaliana


Alignment Length:1185 Identity:231/1185 - (19%)
Similarity:384/1185 - (32%) Gaps:438/1185 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   243 CSNFCEKPEDYV------------KKMNALSE-----------ADAPVESWVRSSPAELYYERTK 284
            |:|:..|   ||            ||.|.:.|           |.:.:|..:......|......
plant   414 CNNWKTK---YVAGNNSGLQNQTRKKQNEIVEDFRRGLVNIIVATSILEEGLDVQSCNLVIRFDP 475

  Fly   285 SEN-----EVRGRARLQK---LCTLFDEELLQRAKRVREKLPVYVPPPRKARRRVCKHKHKSEAC 341
            :.|     :.|||||:|.   |..:...:||.:::.::     |:...::.|.....|     :.
plant   476 ASNICSFIQSRGRARMQNSDYLMMVESGDLLTQSRLMK-----YLSGGKRMREESLDH-----SL 530

  Fly   342 SSSSSSDDDSDEDAFKIEQDCCMEELSRKV----QHPQRVHADLWHNDAGEMN---DGPLC---- 395
            .......|||||..|::|.......||..|    .:..|:.:|.:...|...:   |...|    
plant   531 VPCPPLPDDSDEPLFRVESTGATVTLSSSVSLIYHYCSRLPSDEYFKPAPRFDVNKDQGSCTLYL 595

  Fly   396 --RCSAKSRRIGIRHGIYPGETGYKLC--------------------DPNSNNAGKL-------- 430
              .|..|..:....:.:.......|.|                    :..|....|:        
plant   596 PKSCPVKEVKAEANNKVLKQAVCLKACIQLHKVGALSDHLVPDMVVAETVSQKLEKIQYNTEQPC 660

  Fly   431 -----------------FH-YRISISP--PTNF-----LTKTPTIIKHDEHEFLFEGFSLLSHVR 470
                             :| |.|.:.|  |.||     |..|..:::.|.....|         |
plant   661 YFPPELVSQFSAQPETTYHFYLIRMKPNSPRNFHLNDVLLGTRVVLEDDIGNTSF---------R 716

  Fly   471 LSDLPVCKVIRFNIEYTIEY--------EEEKMPENFTIHELDIFFKYLFHELLELVDFNLMPNL 527
            |.|      .|..|..|:.|        ||......|.|        .||..||:....|||   
plant   717 LED------HRGTIAVTLSYVGAFHLTQEEVLFCRRFQI--------TLFRVLLDHSVENLM--- 764

  Fly   528 PSGNVEESCPAFHFFPRFVRD--------LPDNGKEVLAMV--EVLRYLLDNSAQLVERQQ---- 578
                  |:....|     :||        :|.......:::  ||:|.:...|.:::|:.:    
plant   765 ------EALNGLH-----LRDGVALDYLLVPSTHSHETSLIDWEVIRSVNLTSHEVLEKHENCST 818

  Fly   579 -----LLHL-----------NQISQSEWQNYVDFIKGM--------LVTKPGYKPCSLRVDQLDR 619
                 :||.           |.:..:....||...||:        |:||              |
plant   819 NGASRILHTKDGLFCTCVVQNALVYTPHNGYVYCTKGVLNNLNGNSLLTK--------------R 869

  Fly   620 NNSDLPECVDRETGISHPAIVHFGICHPQLSYAGNPEYQKAWREYVKYRHLMANMSKPSFKDKRK 684
            |:.|       :|.|.:....| ||   ||::...|        .:..||:....|......|:|
plant   870 NSGD-------QTYIEYYEERH-GI---QLNFVDEP--------LLNGRHIFTLHSYLHMAKKKK 915

  Fly   685 LEEKEQRLQEMRTQGRMKRNITVAISSEGFYRTGIMCDVVQHAMLIPVLTGHLRFHKSLDLLEES 749
            .:|.::...|:..:                     :|    |.:|.|:         |:|::   
plant   916 EKEHDREFVELPPE---------------------LC----HVILSPI---------SVDMI--- 943

  Fly   750 IGYRFKNRYLLQLALTHPSYKENYGTNPDHARNSLTNCGIRQPEYGDRKIHYMNTRKRGINTLVS 814
            ..|.|....:.::.....:|         :.:.|:....|..                 |..|.:
plant   944 YSYTFIPSVMQRIESLLIAY---------NLKKSIPKVNIPT-----------------IKVLEA 982

  Fly   815 IMSRFGKEHETVSNITHNERLEFLGDAVVEFLSSIHLFFMFPELEEGGLATYRAAIVQNQHLALL 879
            |.::..::.      .|.|.||.|||:.:::.....||.......||.|:|.:..::.|..|...
plant   983 ITTKKCEDQ------FHLESLETLGDSFLKYAVCQQLFQHCHTHHEGLLSTKKDGMISNVMLCQF 1041

  Fly   880 AKKLQLEEFMLYAHGSDLCHELE---------------------------------LRHAMANCF 911
            ..:.:|:.|:     .|.|.|.:                                 .|.::|:..
plant  1042 GCQQKLQGFI-----RDECFEPKGWMVPGQSSAAYSLVNDTLPESRNIYVASRRNLKRKSVADVV 1101

  Fly   912 EALMGALLLDG------------GIKVADEVFTDALFRQDEKLLSIWKNLPEHPLQEQEPLGDRS 964
            |:|:||.|.:|            ||||.   ||....::|.            |:| .|.|.:..
plant  1102 ESLIGAYLSEGGELAALMFMNWVGIKVD---FTTTKIQRDS------------PIQ-AEKLVNVG 1150

  Fly   965 CIDSYRVLKELTKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGS---------NQRLEFLGDT 1020
            .::|                      ||..:|.|:|:....||.||         .||||||||:
plant  1151 YMES----------------------LLNYSFEDKSLLVEALTHGSYMMPEIPRCYQRLEFLGDS 1193

  Fly  1021 VLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANP------------ 1073
            ||..:.:::||..:|....|.|:.:||:.|||...|:|.....:.|:.:||:.            
plant  1194 VLDYLITKHLYDKYPCLSPGLLTDMRSASVNNECYALVAVKANLHKHILYASHHLHKHISRTVSE 1258

  Fly  1074 ------------KADLK-TKDRADLLEAFLGALYVDKGLLYCEQFCHVCLFPRLQLFIMNQDWN- 1124
                        ::|:. .|...|::|:..||::||.|  |.::.....:.|.|...|..:... 
plant  1259 FEQSSLQSTFGWESDISFPKVLGDVIESLAGAIFVDSG--YNKEVVFASIKPLLGCMITPETVKL 1321

  Fly  1125 DPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGPTNTRVYKVAVYFRSKRLA-TSSGSSIQQAEM 1188
            .|..:|.:.|...:              .|.|...:...:.|.|..:....| |:..|..:.|:.
plant  1322 HPVRELTELCQKWQ--------------FELSKAKDFDSFTVEVKAKEMSFAHTAKASDKKMAKK 1372

  Fly  1189 NAAKQA---LENSRD 1200
            .|.|:.   |:||.|
plant  1373 LAYKEVLNLLKNSLD 1387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
droshaNP_477436.1 DLL_N 64..136 CDD:289198
Rnc 738..>974 CDD:223644 50/280 (18%)
RIBOc 826..942 CDD:197778 35/160 (22%)
rnc 973..1196 CDD:234633 60/261 (23%)
RIBOc 990..1117 CDD:197778 46/160 (29%)
DSRM 1125..1196 CDD:238007 13/74 (18%)
DCL2NP_001189798.1 DEXDc 38..192 CDD:238005
Helicase_C 382..489 CDD:278689 15/77 (19%)
Dicer_dimer 560..637 CDD:281376 10/76 (13%)
PAZ_CAF_like 807..937 CDD:239210 32/187 (17%)
RIBOc 980..1123 CDD:238333 30/153 (20%)
Rnc 1151..1384 CDD:223644 62/270 (23%)
RIBOc 1164..1318 CDD:238333 43/155 (28%)
DSRM 1323..1383 CDD:214634 13/73 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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