DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drosha and mrpl44

DIOPT Version :9

Sequence 1:	NP_477436.1	Gene:	drosha / 35747	FlyBaseID:	FBgn0026722	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001025431.2	Gene:	mrpl44 / 571210	ZFINID:	ZDB-GENE-050913-59	Length:	332	Species:	Danio rerio

Alignment Length:	173	Identity:	41/173 - (23%)
Similarity:	73/173 - (42%)	Gaps:	32/173 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   855 FPELEEGGLATYRAAIVQNQHLALLAKKLQLEEFMLYAHGSDLCHELEL-RHAMANCFEALMGAL 918
            ||.|.:.|:|.....:..::.:..:|:.|.:||..:.|       |..: .|.:...|.|::|||
Zfish   143 FPNLPDEGVAAIAGHLTGSEVICHVARNLAVEELTMSA-------EFPVPDHILQGTFFAVIGAL 200

  Fly   919 LLDGGIKVADEVFTDALFRQ--DEKLLSIWKNLPEHPLQEQEPLGDRSCIDSYRVLKELTKFEDS 981
            ....|...|.....|.|..|  .:.|..:||.:        :|:|        .:::|||:
Zfish   201 EQSSGPVRAGLFIRDFLVTQLIGKDLFDMWKVV--------DPMG--------LLVEELTR---- 245

  Fly   982 IGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRL--EFLGDTVL 1022
            .|:.....||:..|.....:....:.|.|:::|  :..|:|||
Zfish   246 KGVALPEPRLIRSAGASTVLPLYFVGLYSDRKLLAQGPGETVL 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	DLL_N	64..136	CDD:289198
		Rnc	738..>974	CDD:223644	27/121 (22%)
		RIBOc	826..942	CDD:197778	22/89 (25%)
		rnc	973..1196	CDD:234633	14/52 (27%)
		RIBOc	990..1117	CDD:197778	10/35 (29%)
		DSRM	1125..1196	CDD:238007
mrpl44	NP_001025431.2	Rnc	<143..303	CDD:223644	41/173 (24%)
mrpl44	NP_001025431.2	DSRM	234..302	CDD:294045	16/67 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900