DRSC/TRiP Functional Genomics Resources

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Protein Alignment drosha and Dcr-1

DIOPT Version :9

Sequence 1:NP_477436.1 Gene:drosha / 35747 FlyBaseID:FBgn0026722 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_524453.1 Gene:Dcr-1 / 42693 FlyBaseID:FBgn0039016 Length:2249 Species:Drosophila melanogaster


Alignment Length:1218 Identity:232/1218 - (19%)
Similarity:383/1218 - (31%) Gaps:460/1218 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   201 RNQVSD-DYS-PRGHHERERNETLEKTR-AKPKVETERDRLLRQWCSNFCEKPEDYVKKMNALSE 262
            |.|:.| |:. |........:|.|:|:| :|.|...:.|.:..:..::..:||.....:::..|:
  Fly  1286 RQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQKESLKDDTINGKDLADVEKKPTSEETQLDKDSK 1350

  Fly   263 ADAPVESWVRSSPAELYYERTKSENEVRGRARLQKLCTLFDEELLQRAKRVREKLPVYVPPPRKA 327
            .|.     |..|..||..|                     .||.||.|....|            
  Fly  1351 DDK-----VEKSAIELIIE---------------------GEEKLQEADDFIE------------ 1377

  Fly   328 RRRVCKHKHKSEACSSSSSSDDDSDEDAFKIEQDCCMEELSRKV----QHPQRVHADLWHNDAGE 388
               :....:......:|.:.:||.::|||.      :..|...|    |..:......|....||
  Fly  1378 ---IGTWSNDMADDIASFNQEDDDEDDAFH------LPVLPANVKFCDQQTRYGSPTFWDVSNGE 1433

  Fly   389 MN-DGPLCRCSAKSRRIGIRHGIYPGETGYKLCDPNS---------NNAGKLFHYRISISPPTN- 442
            .. .||.   |:::::.|......|.:..:...|.::         :|||.|.:...:.|...: 
  Fly  1434 SGFKGPK---SSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDD 1495

  Fly   443 -----------FLTK--TPTIIKHDEHEFLFEGFSLLSHVRLSDLPVCKVIRFNIEYTIEYEEEK 494
                       |.:|  ..||....|.|...:..|::.....::....:.....|.:..::|::|
  Fly  1496 VADDIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQK 1560

  Fly   495 MPENFTIHELDIFFKYLFHELLELVDFNLMPNLPSGNVEESCPAFHFFPRFVRDLPDNGKEVLAM 559
            .|..         .:|                      |||                        
  Fly  1561 EPAT---------IRY----------------------EES------------------------ 1570

  Fly   560 VEVLRYLLDNSAQLVERQQLLHLNQISQSEWQ----NYVDFIKGMLVTKPGYKPCSLRVDQLDRN 620
            :..|:..:::...||...|.|.|.:...:|.|    :.::.:|.:|   |......|.....||.
  Fly  1571 IAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLL---PYVNEDVLAKKLGDRR 1632

  Fly   621 N---SDLPECVDRETGISHPAIVHFGICHPQLSYAGNPEYQKAWREYVKYRHLMANMSKPSFKDK 682
            .   |||.|.                          |.:: .|..|...|..:....|..::.|.
  Fly  1633 ELLLSDLVEL--------------------------NADW-VARHEQETYNVMGCGDSFDNYNDH 1670

  Fly   683 RK--LEEKEQRLQEMRTQ---GRMKRNITVAISSEGFYRTGIMCDVVQHAMLIPVLTGHLRFHKS 742
            .:  |:||:.:||..|.:   ....:.||.||...||                           |
  Fly  1671 HRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGF---------------------------S 1708

  Fly   743 LDLLEESIGYRFKNRYLLQLALTHPSYKENYGTNPDHARNSLTNCGIRQPEYGDRKIHYMNTRKR 807
            .|...:.:|              ||      |.:|.....:||                |:....
  Fly  1709 FDRQPDLVG--------------HP------GPSPSIILQALT----------------MSNAND 1737

  Fly   808 GINTLVSIMSRFGKEHETVSNITHNERLEFLGDAVVEFLSSIHLFFMFPELEEGGLATYRAAIVQ 872
            |||.                     ||||.:||:.:::..:.:|:..:..:.||.|:..|:..|.
  Fly  1738 GINL---------------------ERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVA 1781

  Fly   873 NQHLALLAKKLQLEEFMLYA--------------------------------------------- 892
            |.:|..|.::.:|.|:|:..                                             
  Fly  1782 NLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLADLLDIKNLS 1846

  Fly   893 -----------------------------HGSDLCHE--------LELRH-----AMANCFEALM 915
                                         ..:|.|::        |..:|     ::|:|.|||:
  Fly  1847 SVQICEMVREKADALGLEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALI 1911

  Fly   916 GALL-------------------------LDGGIKV----------ADEVFTDALFRQDEKLLSI 945
            ||.|                         ||||.:.          |:.|.|         :...
  Fly  1912 GAYLIECGPRGALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVVT---------VYGA 1967

  Fly   946 WKNLPEHPLQEQEPLGDRSCIDSYRVLKELTKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGS 1010
            |.. |..||....|..... :|  ::|....:||:|:|.||:....|.:|.|..|.....|| ..
  Fly  1968 WPT-PRSPLLHFAPNATEE-LD--QLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLT-DC 2027

  Fly  1011 NQRLEFLGDTVLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANP-- 1073
            .||||||||.||..:.:.:||....:|..|.|:.|||:||||...|.:....|..|:..:.:|  
  Fly  2028 YQRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGL 2092

  Fly  1074 --------------------------------KADLKT-KDRADLLEAFLGALYVDKGLLYCEQF 1105
                                            ..|::. |...|:.|:..||:::|.. :..:..
  Fly  2093 NDVIDRFVRIQQENGHCISEEYYLLSEEECDDAEDVEVPKALGDVFESIAGAIFLDSN-MSLDVV 2156

  Fly  1106 CHV---CLFPRLQLFIMNQDWNDPKSKLQQCC-LTLRTMDGGEPDIPYYKVVEASGPTNTRVYKV 1166
            .||   .:.|.::.|..:.    |||.:::.. |...|...|:|:    |:.:.      |..:|
  Fly  2157 WHVYSNMMSPEIEQFSNSV----PKSPIRELLELEPETAKFGKPE----KLADG------RRVRV 2207

  Fly  1167 AVYFRSKRLATSSGSSIQQAEMNAAKQALENSRDLFPQLDHQKRVIAK 1214
            .|....|......|.:.:.|:..|||.||.       ||..| .:|||
  Fly  2208 TVDVFCKGTFRGIGRNYRIAKCTAAKCALR-------QLKKQ-GLIAK 2247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
droshaNP_477436.1 DLL_N 64..136 CDD:289198
Rnc 738..>974 CDD:223644 57/357 (16%)
RIBOc 826..942 CDD:197778 37/237 (16%)
rnc 973..1196 CDD:234633 67/261 (26%)
RIBOc 990..1117 CDD:197778 42/164 (26%)
DSRM 1125..1196 CDD:238007 18/71 (25%)
Dcr-1NP_524453.1 DEAD-like_helicase_N 15..208 CDD:421690
Dicer_PBD 240..344 CDD:277191
DEAD-like_helicase_C 490..614 CDD:365791
Dicer_dimer 825..916 CDD:397444
PAZ_dicer_like 1091..1212 CDD:239209
RIBOc 1724..1930 CDD:238333 36/242 (15%)
RIBOc 2008..2172 CDD:238333 42/165 (25%)
DSRM_DICER 2177..2240 CDD:380680 19/79 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0571
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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