DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drosha and mRpL44

DIOPT Version :9

Sequence 1:	NP_477436.1	Gene:	drosha / 35747	FlyBaseID:	FBgn0026722	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_649541.1	Gene:	mRpL44 / 40656	FlyBaseID:	FBgn0037330	Length:	321	Species:	Drosophila melanogaster

Alignment Length:	280	Identity:	63/280 - (22%)
Similarity:	111/280 - (39%)	Gaps:	45/280 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   957 QEPLGD-----RSCIDSYRVLKELTKFEDSIGIKFKHIRLLARAFTDRS-------------IGF 1003
            |:.||.     ||....:....||..|...:|..|: :..|.||||::|             |..
  Fly    44 QKKLGPQKPERRSGFVEWNQRSELFAFGKRLGESFE-LSELQRAFTEKSFAEREEDRRRQLGIEE 107

  Fly  1004 THLTLGSNQRLEFLGDTVLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYA 1068
            :.|.:..|..|...|..:.:.....:|....|:.....|..:.|.|::..|.|.|...|| .|..
  Fly   108 SDLQMPHNSDLVEKGQQIARAYVEAFLQHQLPKVPNEGLQAIASYLLSTETLAHVSTHLG-TKDL 171

  Fly  1069 VYAN---PKADLKTKDRADLLEAFLGALY----VDKGLLYCEQFCHVCLFPRLQLFIMNQDW--N 1124
            :.:.   |.|:.:.|.    |.|.:|||.    :::..::...|  :|  .:|....:.:.|  .
  Fly   172 IQSTEYPPSAESQAKS----LHAVIGALASSSGIERAFIFVRDF--IC--TQLNQKDLLEVWTPQ 228

  Fly  1125 DPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGPTNTRVYKVAVYFRSKRLATSSGSSIQQAEMN 1189
            :|...|::.|.. |.:...||.:    :.:....|....|:|.:|...:.|....|..::.|...
  Fly   229 EPIQLLEKICQE-RKLGEAEPRL----LGDCGKNTVLAAYQVGIYANRQLLGKGFGEDVKTATET 288

  Fly  1190 AAKQALENSRDLFPQLDHQK 1209
            ||..||::   :|...|:::
  Fly   289 AALDALQS---IFDTRDNRR 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	DLL_N	64..136	CDD:289198
		Rnc	738..>974	CDD:223644	5/21 (24%)
		RIBOc	826..942	CDD:197778
		rnc	973..1196	CDD:234633	55/244 (23%)
		RIBOc	990..1117	CDD:197778	33/146 (23%)
		DSRM	1125..1196	CDD:238007	16/70 (23%)
mRpL44	NP_649541.1	Rnc	72..296	CDD:223644	53/238 (22%)
mRpL44	NP_649541.1	RIBOc	81..219	CDD:197778	33/146 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11207
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000