Protein Alignment drosha and Dcr-2

DIOPT Version :10

• Sequence 1: NP_477436.1
• Gene: drosha / 35747
• FlyBaseID: FBgn0026722
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Alignment Length: 1423
• Identity: 267/1423 - (18%)
• Similarity: 433/1423 - (30%)
• Gaps: 561/1423 - (39%)

  Fly   201 RNQVSDDYSPRGHHERERNETLEKTRAKPKVETERD---RLLRQWCSNFCEKPEDYVKKMNALSE 262
            ||.:|.|:          ...||:...|..::..||   .|:  .||:..|:..| |:..|.:..
  Fly   427 RNNISPDF----------ESVLERKWQKSAIQQFRDGNANLM--ICSSVLEEGID-VQACNHVFI 478

  Fly   263 ADAPVESWVRSSPAELYYERTKSENEVRGRARLQKLCTLFDEELLQRAKRVREKLPVYVPPPRKA 327
            .| ||:::      .:|.:.       :||||     |...:.:|..|.:.|||....:...|||
  Fly   479 LD-PVKTF------NMYVQS-------KGRAR-----TTEAKFVLFTADKEREKTIQQIYQYRKA 524

  Fly   328 RRRVCKH-------KHKSEACSSSSSSDDDSDEDAFKIEQDCCM---EELSRKVQHPQRVHADL- 381
            ...:.::       |.:.|.........||.  |.|..|....:   ..|:...::.|.:..|.
  Fly   525 HNDIAEYLKDRVLEKTEPELYEIKGHFQDDI--DPFTNENGAVLLPNNALAILHRYCQTIPTDAF 587

  Fly   382 -----WHNDAGEMNDGPLCRCSAKSRRI---------GIRHGIYPG----------ETGYKLC-- 420
                 |.:...|.....:...|||.:.:         .:|..||..          ...:|.|
  Fly   588 GFVIPWFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRDTIYSDPMDNVKTAKISAAFKACKV 652

  Fly   421 -----DPNSNNAGKLFHYRISISPPTNFL-------TKTPTIIKHDEH-------EFLFEGFSLL 466
                 :.|.....|....|::.....:|.       :.|.|:.|.|:.       |...|.:..|
  Fly   653 LYSLGELNERFVPKTLKERVASIADVHFEHWNKYGDSVTATVNKADKSKDRTYKTECPLEFYDAL 717

  Fly   467 SHVRLSDLPVCKVIRFNIE---YTIEYEEE-----KMPENFTIHELDIFFKYLFHELLELVDFNL 523
            ..|.    .:|......:|   .:.||.|.     :.|.|:.|        .|.::|..|.:..|
  Fly   718 PRVG----EICYAYEIFLEPQFESCEYTEHMYLNLQTPRNYAI--------LLRNKLPRLAEMPL 770

  Fly   524 MPN----------------LPSGNVEESCPAFH----------FFPRFVRDLPDNGKEVLAMVEV 562
            ..|                :.:....|....||          :.|.||.|........|.:..:
  Fly   771 FSNQGKLHVRVANAPLEVIIQNSEQLELLHQFHGMVFRDILKIWHPFFVLDRRSKENSYLVVPLI 835

  Fly   563 LR---------YLLDNSAQLVERQQLLHLNQISQSEWQN---------------YVDFIKGMLVT 603
            |.         .|:.|..:|.:.    |.:.:.|.|.|.               |.::.|.||||
  Fly   836 LGAGEQKCFDWELMTNFRRLPQS----HGSNVQQREQQPAPRPEDFEGKIVTQWYANYDKPMLVT 896

  Fly   604 KPGYKPCSLRVDQLDRNNSDLPECVDRETGISHPAIVHFGICHPQLSYAGNPEYQKAWREYV--K 666
            |                       |.||.              ..|||....:..|.:.|:.  |
  Fly   897 K-----------------------VHREL--------------TPLSYMEKNQQDKTYYEFTMSK 924

  Fly   667 YRHLMANMSKPSFKDKRKLEEKEQRLQEMRT---------QGRMKRNITVAISSEGFYRTGIMCD 722
            |.:.:.::   ..|||..:|.::  |.|..|         ..:.|..:.|.:..|..:......|
  Fly   925 YGNRIGDV---VHKDKFMIEVRD--LTEQLTFYVHNRGKFNAKSKAKMKVILIPELCFNFNFPGD 984

  Fly   723 VVQHAMLIPVLTGHLRFHKSLDLLE-ESIGYRFKNRYL-LQLA-------LTHP-----SYKENY 773
            :....:.:|.:...:.|     ||. |::..|| |.|| |.|.       :..|     |.|.|.
  Fly   985 LWLKLIFLPSILNRMYF-----LLHAEALRKRF-NTYLNLHLLPFNGTDYMPRPLEIDYSLKRNV 1043

  Fly   774 G--------------------------------------TNP--------DHARNSLTN------ 786
            .                                      .||        |.:||.|:.
  Fly  1044 DPLGNVIPTEDIEEPKSLLEPMPTKSIEASVANLEITEFENPWQKYMEPVDLSRNLLSTYPVELD 1108

  Fly   787 ----------CGIRQPEYGDRKIHYMN------------------------------TRKRGINT 811
                      |.:.:.::.|::....|                              |.:..:..
  Fly  1109 YYYHFSVGNVCEMNEMDFEDKEYWAKNQFHMPTGNIYGNRTPAKTNANVPALMPSKPTVRGKVKP 1173

  Fly   812 LVSIMSRFGKEHET---------------VSNITHNERLEFLGDAVVEFLSSIHLFFMFPELEEG 861
            |:.:.....|||.|               .:::...||||.|||:.::..::::|...:.:..||
  Fly  1174 LLILQKTVSKEHITPAEQGEFLAAITASSAADVFDMERLEILGDSFLKLSATLYLASKYSDWNEG 1238

  Fly   862 GLATYRAAIVQNQHL------ALLAKKLQLEEF-------------------------------- 888
            .|...::.:|.|::|      |.:.|.|...:|
  Fly  1239 TLTEVKSKLVSNRNLLFCLIDADIPKTLNTIQFTPRYTWLPPGISLPHNVLALWRENPEFAKIIG 1303

  Fly   889 -------------------------------------MLYAHGSDLCHELEL--------RHAMA 908
                                                 ..|| |:|...|:..        ...:|
  Fly  1304 PHNLRDLALGDEESLVKGNCSDINYNRFVEGCRANGQSFYA-GADFSSEVNFCVGLVTIPNKVIA 1367

  Fly   909 NCFEALMGALLLDGGIKVAD---EVFTDALFRQD-EKLLSIWKNLPEHPLQEQEPLGDRSC---- 965
            :..|||:|.::.:.|::.|.   |.|  .:.|.| :|.|:...||         .||.:..
  Fly  1368 DTLEALLGVIVKNYGLQHAFKMLEYF--KICRADIDKPLTQLLNL---------ELGGKKMRANV 1421

  Fly   966 ----IDSYRVLKELTKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTVLQLIC 1026
                ||.:  |......|.::|..||..|.|.:|.|..|.....:| ||.|.|||:||.:|..:.
  Fly  1422 NTTEIDGF--LINHYYLEKNLGYTFKDRRYLLQALTHPSYPTNRIT-GSYQELEFIGDAILDFLI 1483

  Fly  1027 SEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVC-------------------------------- 1059
            |.|::.:..:.:.|.|:.|||:||||.|.|.:|
  Fly  1484 SAYIFENNTKMNPGALTDLRSALVNNTTLACICVRHRLHFFILAENAKLSEIISKFVNFQESQGH 1548

  Fly  1060 -----------------------DDLGMPKYAVYAN------------PKADLK-------TKDR 1082
                                   |:|.|.:.. :||            ||.:..       .|..
  Fly  1549 RVTNYVRILLEEADVQPTPLDLDDELDMTELP-HANKCISQEAEKGVPPKGEFNMSTNVDVPKAL 1612

  Fly  1083 ADLLEAFLGALYVDKGLLYCEQFCHVC-----LF-PRLQLFIMNQDWNDPKSKLQQCCLTLRTMD 1141
            .|:|||.:.|:|:|     |.......     || |.||.|......|..:..::.
  Fly  1613 GDVLEALIAAVYLD-----CRDLQRTWEVIFNLFEPELQEFTRKVPINHIRQLVEH--------- 1663

  Fly  1142 GGEPDIPYYKVVEASGPTNTRVYKVAVYF--RSKRLAT-SSGSSIQQAEMNAAKQALE 1196
                  .:.|.|.:|.........|:..|  ..|.:.. ..||:..||:::|||.||:
  Fly  1664 ------KHAKPVFSSPIVEGETVMVSCQFTCMEKTIKVYGFGSNKDQAKLSAAKHALQ 1715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	RIBOc	826..942	CDD:197778	34/202 (17%)
		Rnc	973..1196	CDD:440336	70/305 (23%)
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792
		Dicer_PBD	241..343	CDD:277191
		SF2_C_dicer	360..506	CDD:350189	26/110 (24%)
		Dicer_dimer	571..670	CDD:460900	15/98 (15%)
		PAZ	843..1004	CDD:198017	38/211 (18%)
		RIBOc	1194..1391	CDD:238333	30/197 (15%)
		RIBOc	1448..1649	CDD:238333	50/207 (24%)
		dsrm	1653..1717	CDD:425434	16/78 (21%)