DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drosha and dicer1

DIOPT Version :9

Sequence 1:	NP_477436.1	Gene:	drosha / 35747	FlyBaseID:	FBgn0026722	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001154925.1	Gene:	dicer1 / 324724	ZFINID:	ZDB-GENE-030131-3445	Length:	1865	Species:	Danio rerio

Alignment Length:	1634	Identity:	294/1634 - (17%)
Similarity:	488/1634 - (29%)	Gaps:	701/1634 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 PSERQRYTS----NSSSQGYHHYPGYSSGRRYEQRHDQEHRQ------------------IQDSR 173
            |.|||::.|    |:.:|  .:|..:|.....::..:.|.::                  ..:.|
Zfish   375 PFERQQFESVEWYNNRNQ--DNYVSWSDSEDDDEDEEAEAKEKTEANFPSPFTNILCGIIFVERR 437

  Fly   174 YA-------------HEPRHGHYAHRQAKGSQHGYYGSAARNQVSDDYSPRGHHE----RERNET 221
            |.             .:|...:.:.....|.      |..:||      ||....    |::.|.
Zfish   438 YTAVVLNRLIKEAGKQDPELAYISSNFITGH------SIGKNQ------PRNKQMEVEFRKQEEV 490

  Fly   222 LEKTRAKPKVETERDRLLRQWCSNFCEKPEDYVKKMNALSEADAPVE--SWVRSSPAELYYERTK 284
            |.|.||.     |.:.|:   .::..|:..| :.|.|.:...|.|.|  |:|:|
Zfish   491 LRKFRAH-----ETNLLI---ATSIVEEGVD-IPKCNLVVRFDLPTEYRSYVQS----------- 535

  Fly   285 SENEVRGRAR--LQKLCTLFDEELLQRAKRVREKLPVYVPPPRKARRRVCKHK-HKSEACSS--- 343
                 :||||  :.....|.|.|   |.|..:|.|..|     ||..::.::| .||..|:.
Zfish   536 -----KGRARAPVSNYIMLADSE---RTKTFQEDLKTY-----KAIEKILRNKCSKSAECNDFEL 587

  Fly   344 SSSSDDD---------SDEDAFKIEQDCCMEELSRKVQHPQRVHADLWHNDAG-----EMNDG-- 392
            ...:|||         |::...::..:..:..::|   :..|:.:|.:.:.|.     |||.|
Zfish   588 EPVTDDDNVLPPYVLRSEDGGPRVTMNTAIGHVNR---YCARLPSDPFTHLAPKCKTVEMNTGGY 649

  Fly   393 ----------PL----------CR----------CSAKSRRIG-------------IRH------ 408
                      ||          |.          |..|..:||             :::
Zfish   650 RSTLFLPINSPLRVPVTGPVMNCARLAEKAVALLCCEKLHKIGELDDHLMPVGKETVKYEEELDL 714

  Fly   409 ---------GIYPGETGYKLCDPNSNNAGKLFHYRISISP----PTNFLTKTPTIIKHDEHEF-- 458
                     | .||.|..:.|.|.:........|.:...|    ....:..||.   .||..|
Zfish   715 HDEEETSVPG-RPGSTKRRQCSPKAIPECLRGCYPVPEQPCYLYVIGMVLTTPL---PDELNFRR 775

  Fly   459 --LF------EGFSLLSHVRLSDLPVCKVIRFNIEYTIEYEEEKMPENFTIHELDI---FFKYLF 512
              |:      ..|.:|:...:..:|...|...:.|.||..|.:|...:.:..:|::   ..:|:|
Zfish   776 RKLYPPEDTTRCFGILTAKPIPRIPHFPVYTRSGEVTISIELQKSGFSLSAEQLELITRLHQYIF 840

  Fly   513 HELLELVDFNLMPNLPSGNVEESCPAFHFFPRFVRDLPDNGKEVLAMVEVLRYLLDNSAQLVERQ 577
            ..:|.|                ..||..|.|                ||.      :||..|
Zfish   841 SHILRL----------------EKPALEFKP----------------VEA------DSAYCV--- 864

  Fly   578 QLLHLNQISQSEWQNYVDF-IKGMLVTKPGYKPCSLRVDQLDRNNSDLPECVDRETGISHPAIVH 641
              |.||.:..|   |.:|. .|.|...:.......:...|..:.|..:.:..|.:..:..|...:
Zfish   865 --LPLNIVEDS---NTLDLDFKFMEDIEKSEARIGIPNTQYTKQNPFIFKLEDYQDAVIIPRYRN 924

  Fly   642 FGICH-----------PQLSYAGNPEYQKAWREY--VKYRHLMANMSKP-----------SFKDK 682
            |...|           ..||...:|||: .:.||  .||...::|:::|           :....
Zfish   925 FDQPHRFYVADVYTDLTPLSKFPSPEYE-TFAEYYKTKYNLDLSNVNQPLLDVDHTSSRLNLLTP 988

  Fly   683 RKLEEKEQRL-------QEMRTQGRMKRNITV----AISSEGFYRTGIMCDVVQHAMLIPVLTGH 736
            |.|.:|.:.|       ::.:.:....:.|.|    ||..       |...:.:.|:.:|.:.
Zfish   989 RHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHP-------IPASLWRKAVCLPSIL-- 1044

  Fly   737 LRFH--------KSLDLLEESIG-------YRFKNRYLLQLA----------LTHPS--YKEN-- 772
            .|.|        :|...::..:|       :|:.|   |...          ::.||  .:|:
Zfish  1045 YRLHCLLTAEELRSQTAIDAGVGAQTLPPDFRYPN---LDFGWKKSIDSKSFISCPSACMEEDDD 1106

  Fly   773 ---YGTNPDHARNSLTNCG--IRQPEYG-----DRKIHYMNTRKRGIN----------------- 810
               .||:.|....:..:|.  :.||..|     |.|:..:......:|
Zfish  1107 HCKLGTSSDSNHTAPESCSMEVSQPPEGAPNTPDEKLETLTLPVTDLNKDCFPNLPNGTQADSDD 1171

  Fly   811 -----------------------TLVSIMSR---------------FGKEHE------------- 824
                                   |..|:..|               .|:..:
Zfish  1172 LPHRSDVCQCSQLGPLERDLSTQTTTSVSVRPSPAGEPQPWPSDECTGRSSDLCDPHVKKPTSKH 1236

  Fly   825 -----------------------------------------------TVSNITHN---ERLEFLG 839
                                                           |:||.:..   ||||.||
Zfish  1237 CPKSETATSTPAPSETSSEDCRSACAGPAWDSPKTLGPNPGLILQALTLSNASDGFNLERLEMLG 1301

  Fly   840 DAVVEFLSSIHLFFMFPELEEGGLATYRAAIVQNQHLALLAKKLQLEEFML-------------- 890
            |:.::...:.:||..:|:..||.|:..|:..|.|.:|..|.||..|...|:
Zfish  1302 DSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPG 1366

  Fly   891 -----------------------------------------------------------YAH--- 893
                                                                       |.|
Zfish  1367 YVVNQDKSSTDKWDSDENKDLANGKASDDEDEDDDDEPEEAEVEPSKEDVNVEDDLEYYYEHIRF 1431

  Fly   894 -----------------------------------------GSD---------LC---------- 898
                                                     |:|         :|
Zfish  1432 IDSMLIGSGAFGKKISLQPTDPGYEWKAPKKAHNSHFSPDGGADEFDYSSWDAMCYLDPSKAGEE 1496

  Fly   899 -------------------------HELELRH-----AMANCFEALMGALLLDGGIKVADEVFTD 933
                                     ::|....     ::|:|.|||:|..|...|.:.| ::|..
Zfish  1497 DDFVVGFWNPSEENCGTDIGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAA-QLFLC 1560

  Fly   934 ALFRQ-----------DEKLLSIWKNLP-----EHPLQEQEPLGDRSCIDSYRVLKEL----TKF 978
            :|..:           ..:|...|..:|     |||             |:.|.|..|    ..|
Zfish  1561 SLGLKVLPPEKQSSGGSAELQYGWLKIPPRCMFEHP-------------DAERTLNHLISGFLNF 1612

  Fly   979 EDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTVLQLICSEYLYRHFPEHHEGHLS 1043
            |..|...||:...|.:|||..|..:..:| ...||||||||.:|..:.:::||....:|..|.|:
Zfish  1613 ESKINYTFKNKAYLLQAFTHASYHYNTIT-DCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLT 1676

  Fly  1044 LLRSSLVNNRTQAVVCDDLGMPKYAVYANPK----------------------ADLK-------- 1078
            .|||:||||...|.:.......||....:|:                      ::|:
Zfish  1677 DLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEK 1741

  Fly  1079 ------TKDRADLLEAFLGALYVDKGLLYCEQFCHVCLFPRLQLFIMNQDWNDPKSKLQQCCLTL 1137
                  .|...|:.|:..||:|:|.| :..|....| .:|.::..|.....|.|:|.:::    |
Zfish  1742 EEDIEVPKAMGDIFESLAGAIYMDSG-MSLETVWQV-YYPMMRPLIEKFSANVPRSPVRE----L 1800

  Fly  1138 RTMDGGEPDIPYYKVVEASGPTNTRVY----KVAVYFRSKRLATSSGSSIQQAEMNAAKQALENS 1198
            ..|   ||:...:...|       |.|    :|.|....|......|.|.:.|:..||::||.:.
Zfish  1801 LEM---EPETAKFSPAE-------RTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSL 1855

  Fly  1199 RDLFPQLDH 1207
            :...||:.:
Zfish  1856 KANQPQVQN 1864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	DLL_N	64..136	CDD:289198	3/4 (75%)
		Rnc	738..>974	CDD:223644	75/574 (13%)
		RIBOc	826..942	CDD:197778	41/295 (14%)
		rnc	973..1196	CDD:234633	69/266 (26%)
		RIBOc	990..1117	CDD:197778	43/162 (27%)
		DSRM	1125..1196	CDD:238007	18/74 (24%)
dicer1	NP_001154925.1	helicase_insert_domain	27..586	CDD:327377	55/257 (21%)
		DECH box	161..164
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..417		2/19 (11%)
		Dicer_dimer	616..704	CDD:308785	15/90 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..732		4/19 (21%)
		PAZ_dicer_like	872..994	CDD:239209	24/125 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1142		8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1259		4/68 (6%)
		RIBOc	1278..>1369	CDD:197778	25/90 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1373..1417		0/43 (0%)
		Rnc	1609..1861	CDD:223644	69/268 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810