DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drosha and Drosha

DIOPT Version :9

Sequence 1:	NP_477436.1	Gene:	drosha / 35747	FlyBaseID:	FBgn0026722	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001101125.2	Gene:	Drosha / 310159	RGDID:	1307626	Length:	1373	Species:	Rattus norvegicus

Alignment Length:	1316	Identity:	617/1316 - (46%)
Similarity:	826/1316 - (62%)	Gaps:	164/1316 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PPLPPPPVQPAPPPPPPPPEE--DLSPPGV--GVPSHNYSSNESHSQSSKSLDYVYPETPAPYAS 64
            |.:.|||..|.|||||..|::  ...|||.  ..|..|::|.:::|.|       :|  |:...|
  Rat   142 PFMVPPPSMPHPPPPPVMPQQVNYQYPPGYSHSFPPPNFNSFQNNSSS-------FP--PSANNS 197

  Fly    65 SVPSY---DPYQQPPAYG----------YEGYAYNEQAQKYGGQESHYQYQYPASGSSFLYESYK 116
            |.|.:   .||..|.|..          |:.:.:.:.:  :|..|.|...:....|.|
  Rat   198 STPHFRHLPPYSLPKAQSERRSPERLKHYDDHRHRDHS--HGRGERHRSLERRERGRS------- 253

  Fly   117 YPDRYPAYSSNYRPPSERQRYTSNSSSQGYHHYPGYSSGRRYEQRHDQEHRQIQDSRYAHEPRHG 181
             |:|       .||.|   ||.|.           |..||....|    ||..:.||.....||.
  Rat   254 -PER-------RRPES---RYRSE-----------YDRGRTPPPR----HRSYERSRERERERHR 292

  Fly   182 HYAHRQAKGSQHGY---YGSAARN---------------------QVSDDYSPRGHHERERNETL 222
            |..:|::...:..|   |..:.|:                     :.:|.::|...:...|:.:.
  Rat   293 HRENRRSPSLERAYKKEYKRSGRSYGLPVTPEPAGCTAELPGEIIKNTDSWAPPQENVNHRSPSR 357

  Fly   223 EKTRAKPKVETERDRLLRQWCSNFCEKPEDYVKKMNALSEADAPVES------------WVRSSP 275
            ||.||  :.|.|:||    |..:.....|.....:......:||.|.            |:|.:.
  Rat   358 EKKRA--RWEEEKDR----WSDSQSSGKEKSYTSIKEKEPEEAPPEKTEEEDEELLKPVWIRCTH 416

  Fly   276 AELYYERTK----SENEVRGRARLQKLCTLFDEELLQRAKRVREKLPVYVPPPRKARRRVCKHKH 336
            :|.||....    .::.|.|.:||:.|...|:|||..|.::.:...|.:.||..|.
  Rat   417 SESYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGNRQEKAKAARPPWEPPKTKL--------- 472

  Fly   337 KSEACSSSSSSDDDSDEDA----------FKIEQDCCMEELSRKVQHPQRVHADLWHNDAGEMND 391
             .|...|||.|:.::|||:          |.:     :.|:.||..||.|:|.:||:||.|:|||
  Rat   473 -DEDLESSSESECETDEDSTCSSSSDSEVFDV-----IAEIKRKKAHPDRLHDELWYNDPGQMND 531

  Fly   392 GPLCRCSAKSRRIGIRHGIYPGETGYKLCDPNSNNAGKLFHYRISISPPTNFLTKTPTIIKHDEH 456
            ||||:||||:||.||||.|||||...|.|.|.:||||:||||||::||||||||..||:|::|:|
  Rat   532 GPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDH 596

  Fly   457 EFLFEGFSLLSHVRLSDLPVCKVIRFNIEYTIEYEEEKMPENFTIHELDIFFKYLFHELLELVDF 521
            |::|||||:.:|..|:::|:||||||||:|||.:.||.|||||.:..|::|..:||.::|||.|:
  Rat   597 EYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDW 661

  Fly   522 NLMPNLPSGNVEES---CPAFHFFPRFVRDLPDNGKEVLAMVEVLRYLLDNSAQLVERQQLLHLN 583
            ||...|    .|:|   ||.|||.|||||.|||.|||||:|.::|.|||..|..||..:::.::.
  Rat   662 NLKGPL----FEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANML 722

  Fly   584 QISQSEWQNYVDFIKGMLVTKPGYKPCSLRVDQLDRNNSDLPECVDRETGISHPAIVHFGICHPQ 648
            |..:.|||.|.:..|||:||.||.||.|:|:|||||...: ||.      |:.|.||||||...|
  Rat   723 QWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFN-PEV------ITFPIIVHFGIRPAQ 780

  Fly   649 LSYAGNPEYQKAWREYVKYRHLMANMSKPSFKDKRKLEEKEQRLQEMRTQGRMKRNITVAISSEG 713
            |||||:|:|||.|:.|||.|||:||..|....||:||.::|:.||::|.:..|:|.:||.:||:|
  Rat   781 LSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQG 845

  Fly   714 FYRTGIMCDVVQHAMLIPVLTGHLRFHKSLDLLEESIGYRFKNRYLLQLALTHPSYKENYGTNPD 778
            |::|||..||.||||::||||.|:|:|:.|..|::.|||.|::|.|||||:||||:..|:|.|||
  Rat   846 FWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPD 910

  Fly   779 HARNSLTNCGIRQPEYGDRKIHYMNTRKRGINTLVSIMSRFGKEHETVSNITHNERLEFLGDAVV 843
            ||||||:|||||||:|||||:|:|:.||:|||||::||||.|::..|.|.|.|||||||||||||
  Rat   911 HARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVV 975

  Fly   844 EFLSSIHLFFMFPELEEGGLATYRAAIVQNQHLALLAKKLQLEEFMLYAHGSDLCHELELRHAMA 908
            |||:|:||:::||.||||||||||.|||||||||:|||||:|:.|||||||.|||.|.:||||||
  Rat   976 EFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMA 1040

  Fly   909 NCFEALMGALLLDGGIKVADEVFTDALFRQDEKLLSIWKNLPEHPLQEQEPLGDRSCIDSYRVLK 973
            ||||||:||:.|:|.::.|.::|...|| .|..|..:|.|.|.||||.|||..||..|::..||:
  Rat  1041 NCFEALIGAVYLEGTLEEAKQLFGRLLF-NDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQ 1104

  Fly   974 ELTKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTVLQLICSEYLYRHFPEHH 1038
            :||:||::||:.|.|:||||||||.|::||.|||||.|||:|||||:::||:.:|||:.|||:||
  Rat  1105 KLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHH 1169

  Fly  1039 EGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANPKAD----LKTKDRADLLEAFLGALYVDKGL 1099
            ||||:|||||||||||||.|.::|||.:||: .|.|..    |:||..|||||:|:.|||:||.|
  Rat  1170 EGHLTLLRSSLVNNRTQAKVAEELGMQEYAI-TNDKTKRPVALRTKTLADLLESFIAALYIDKDL 1233

  Fly  1100 LYCEQFCHVCLFPRLQLFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGPTNTRVY 1164
            .|...|.:||.||||:.||:|||||||||:|||||||||| :|.|||||.||.::..||::.|.|
  Rat  1234 EYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRT-EGKEPDIPLYKTLQTVGPSHARTY 1297

  Fly  1165 KVAVYFRSKRLATSSGSSIQQAEMNAAKQALENSRDLFPQLDHQKRVIAKSIKKQTGNELDNDSD 1229
            .|||||:.:|:....|.|||||||.||..|||...  |||:.||||.|.:..:::.   .:...:
  Rat  1298 TVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYN--FPQMAHQKRFIERKYRQEL---KEMRWE 1357

  Fly  1230 RQHQE------EKIKR 1239
            |:|||      |.||:
  Rat  1358 REHQEREPDEAEDIKK 1373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	DLL_N	64..136	CDD:289198	18/84 (21%)
		Rnc	738..>974	CDD:223644	152/235 (65%)
		RIBOc	826..942	CDD:197778	80/115 (70%)
		rnc	973..1196	CDD:234633	140/226 (62%)
		RIBOc	990..1117	CDD:197778	82/130 (63%)
		DSRM	1125..1196	CDD:238007	43/70 (61%)
Drosha	NP_001101125.2	SF-CC1	212..>274	CDD:273721	18/92 (20%)
		RIBOc	958..1078	CDD:238333	81/120 (68%)
		rnc	1104..1332	CDD:234633	142/229 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338155
Domainoid	1	1.000	619	1.000	Domainoid score	I173
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8293
Inparanoid	1	1.050	1109	1.000	Inparanoid score	I214
OMA	1	1.010	-	-		QHG48888
OrthoDB	1	1.010	-	-		D58671at33208
OrthoFinder	1	1.000	-	-		FOG0003184
OrthoInspector	1	1.000	-	-		oto95606
orthoMCL	1	0.900	-	-		OOG6_101368
Panther	1	1.100	-	-	LDO	PTHR11207
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4740
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770