DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drosha and Dicer1

DIOPT Version :9

Sequence 1:NP_477436.1 Gene:drosha / 35747 FlyBaseID:FBgn0026722 Length:1327 Species:Drosophila melanogaster
Sequence 2:XP_008763126.1 Gene:Dicer1 / 299284 RGDID:1309381 Length:1918 Species:Rattus norvegicus


Alignment Length:1646 Identity:292/1646 - (17%)
Similarity:481/1646 - (29%) Gaps:706/1646 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 PSERQRYTS----NSSSQGYHHYPGYSSGRRYEQRHDQEHRQIQDS------------------- 172
            |.|||::.|    |:.:|  .:|..:|     :...|.:..:|::.                   
  Rat   389 PYERQQFESVEWYNNRNQ--DNYVSWS-----DSEDDDDDEEIEEKEKPETNFPSPFTNILCGII 446

  Fly   173 ----RYA-------------HEPRHGHYAHRQAKGSQHGYYGSAARNQVSDDYSPRGHHE----R 216
                ||.             .:|...:.:.....|  ||    ..:||      ||....    |
  Rat   447 FVERRYTAVVLNRLIKEAGKQDPELAYISSNFITG--HG----IGKNQ------PRSKQMEAEFR 499

  Fly   217 ERNETLEKTRAKPKVETERDRLLRQWCSNFCEKPEDYVKKMNALSEADAPVE--SWVRSSPAELY 279
            ::.|.|.|.||.     |.:.|:   .::..|:..| :.|.|.:...|.|.|  |:|:|      
  Rat   500 KQEEVLRKFRAH-----ETNLLI---ATSVVEEGVD-IPKCNLVVRFDLPTEYRSYVQS------ 549

  Fly   280 YERTKSENEVRGRAR--LQKLCTLFDEELLQRAKRVREKLPVYVPPPRKARRRVCKHKHKSEACS 342
                      :||||  :.....|.|.:   :.|...|.|..|....:..|.:..|....:||..
  Rat   550 ----------KGRARAPISNYVMLADTD---KIKSFEEDLKTYKAIEKILRNKCSKSVDGAEADV 601

  Fly   343 SSSSSDDD--------SDEDAFKIEQDCCMEELSRKVQHPQRVHADLWHNDAGEMNDGPLCRCSA 399
            .:...|||        .|:...::..:..:..::|   :..|:.:|.:.:.|      |.||   
  Rat   602 HAVVDDDDVFPPYVLRPDDGGPRVTINTAIGHINR---YCARLPSDPFTHLA------PKCR--- 654

  Fly   400 KSRRIGIRHGIYPGETGYK-------------------------------LCDPNSNNAGKLFHY 433
             :|.:       |..|.|.                               :|....:..|:|..:
  Rat   655 -TREL-------PDGTFYSTLYLPINSPLRASIVGPPMGCVRLAERVVALICCEKLHKIGELDEH 711

  Fly   434 RISISPPTNFLTKTPTIIKHDEHEFLFEG------------------------------------ 462
            .:.:...|  :.....:..|||.|....|                                    
  Rat   712 LMPVGKET--VKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRESYPKPDQPCYLYVIG 774

  Fly   463 ---------------------------FSLLSHVRLSDLPVCKVIRFNIEYTIEYEEEKMPENFT 500
                                       |.:|:...:..:|...|...:.|.||..|.:|  ..||
  Rat   775 MVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKK--SGFT 837

  Fly   501 IHE--LDI---FFKYLFHELLEL-------------------------------VDFNLMPN--- 526
            :.:  |::   ..:|:|..:|.|                               :||..|.:   
  Rat   838 LSQQMLELVTRLHQYIFSHILRLEKPALEFQPAGAESAYCVLPLNVVNDSSTLDIDFKFMEDIEK 902

  Fly   527 ------LPSGNVEESCPAFHF----------FPR----------FVRDL----------PDNGKE 555
                  :||....:..| |.|          .||          :|.|:          |....|
  Rat   903 SEARIGIPSTKYSKETP-FVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYE 966

  Fly   556 VLAMVEVLRYLLD----NSAQL-----VERQQLL---HLNQISQSEWQNYVDFIKGMLVTKPGYK 608
            ..|.....:|.||    |...|     ..|..||   ||||             ||..:.....:
  Rat   967 TFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQ-------------KGKALPLSSAE 1018

  Fly   609 PCSLRVDQLDRNNSDLPE-CVDRETGISHP---AIVHFGICHPQLSY-------AGNPEYQKAWR 662
            ....:.:.|......:|| |.      .||   ::....:|.|.:.|       |.....|.|..
  Rat  1019 KRKAKWESLQNKQILVPELCA------IHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASD 1077

  Fly   663 EYVKYRHLMANMSKPS--FKDKRKLEEK------EQRLQEMRTQGRMKRNITVA----------- 708
            ..|..|.|.|:...|:  |..|:.::.|      ...|.|  :....|.:.||.           
  Rat  1078 AGVGVRSLPADFRYPNLDFGWKKSIDSKSFISTCNSSLAE--SDNYCKHSTTVVPENAAHQGATR 1140

  Fly   709 ISSEGFYRTGIMCDVV----------QHAMLIPVLTGHLRFHKSL-----DLLE------ESIGY 752
            .|.|...:..:.|..:          :.::.:..:.| |.::|||     ||:.      ..:.|
  Rat  1141 PSLENHDQMSVNCKRLPAESPAKLQSEVSVDLTAING-LSYNKSLANGSYDLVNRDFCQGNQLTY 1204

  Fly   753 RFKNRYLLQLALTHPSYK-ENYGTNPDHARNSLTNCGIRQPEYGDRKIHYMNT--------RKRG 808
             ||....:|...::|... .||...|..:    ..|.:...:|.|...:...:        |...
  Rat  1205 -FKQEIPVQPTTSYPIQNLYNYENQPTPS----NECPLLSNKYLDGNANTSTSDGSPAGSPRPAM 1264

  Fly   809 INTLVSIMSRFGKEHE---------------------TVSNITHN---ERLEFLGDAVVEFLSSI 849
            :..:.::..|...|..                     |:||.:..   ||||.|||:.::...:.
  Rat  1265 MTAVEALEGRTDSEQSPSVGHSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITT 1329

  Fly   850 HLFFMFPELEEGGLATYRAAIVQNQHLALLAKK-------------------------------- 882
            :||..:|:..||.|:..|:..|.|.:|..|.||                                
  Rat  1330 YLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKQGLPSRMVVSIFDPPVNWLPPGYVVNQDKSNS 1394

  Fly   883 -----------------------------------------------------LQLEEFMLYAHG 894
                                                                 :|..:.||...|
  Rat  1395 EKWEKDEMTKDCLLANGKLGEDCEEEEEEELAWRAPKEEAEYEDDLLEYDQEHIQFIDSMLMGSG 1459

  Fly   895 -------------SDLCHELEL------------------------------------------- 903
                         ||..:|.::                                           
  Rat  1460 AFVKKIPLSPFSTSDSAYEWKMPKKASLGSVPFSSDLEDFDYSSWDAMCYLDPSKAVEEDDFVVG 1524

  Fly   904 -----------------------------RHAMANCFEALMGALLLDGGIKVADEVFTDALFRQD 939
                                         ..::|:|.|||:|..|...|.:.| ::|..:|   .
  Rat  1525 FWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAA-QLFLCSL---G 1585

  Fly   940 EKLLSIWK----NLPEHPLQE------QEPLG----------------DRSCI-----------D 967
            .|:|.:.|    :...:|.||      :.|.|                :..|:           |
  Rat  1586 LKVLPVIKRTSRDKASYPAQENSSSQQKSPSGSCAAAVSPRSSAGKDLEYGCLKIPPRCMFDHPD 1650

  Fly   968 SYRVLKEL----TKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTVLQLICSE 1028
            :.:.|..|    ..||..|...||:...|.:|||..|..:..:| ...||||||||.:|..:.::
  Rat  1651 AEKTLNHLISGFENFEKKINYIFKNKAYLLQAFTHASYHYNTIT-DCYQRLEFLGDAILDYLITK 1714

  Fly  1029 YLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANPK------------------- 1074
            :||....:|..|.|:.|||:||||...|.:.......||....:|:                   
  Rat  1715 HLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQ 1779

  Fly  1075 ---ADLK--------------TKDRADLLEAFLGALYVDKGL-------LYCEQFCHVCLFPRLQ 1115
               ::|:              .|...|:.|:..||:|:|.|:       :|         :|.::
  Rat  1780 GMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVY---------YPMMR 1835

  Fly  1116 LFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGPTNTRVY----KVAVYFRSKRLA 1176
            ..|.....|.|:|.:::    |..|   ||:...:...|       |.|    :|.|....|...
  Rat  1836 PLIEKFSANVPRSPVRE----LLEM---EPETAKFSPAE-------RTYDGKVRVTVEVVGKGKF 1886

  Fly  1177 TSSGSSIQQAEMNAAKQALEN 1197
            ...|.|.:.|:..||::||.:
  Rat  1887 KGVGRSYRIAKSAAARRALRS 1907

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
droshaNP_477436.1 DLL_N 64..136 CDD:289198 3/4 (75%)
Rnc 738..>974 CDD:223644 71/486 (15%)
RIBOc 826..942 CDD:197778 40/288 (14%)
rnc 973..1196 CDD:234633 68/273 (25%)
RIBOc 990..1117 CDD:197778 42/169 (25%)
DSRM 1125..1196 CDD:238007 18/74 (24%)
Dicer1XP_008763126.1 DEXHc_dicer 42..239 CDD:350792
Dicer_PBD 271..365 CDD:277191
SF2_C_dicer 372..564 CDD:350189 43/218 (20%)
Dicer_dimer 630..718 CDD:397444 14/107 (13%)
PAZ_dicer_like 886..1008 CDD:239209 27/135 (20%)
RIBOc 1296..>1387 CDD:197778 23/90 (26%)
RIBOc 1678..1842 CDD:238333 43/173 (25%)
DSRM_DICER 1847..1909 CDD:380680 18/75 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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