DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drosha and mrpl3

DIOPT Version :9

Sequence 1:	NP_477436.1	Gene:	drosha / 35747	FlyBaseID:	FBgn0026722	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_596672.1	Gene:	mrpl3 / 2541040	PomBaseID:	SPBC3B9.14c	Length:	326	Species:	Schizosaccharomyces pombe

Alignment Length:	262	Identity:	54/262 - (20%)
Similarity:	101/262 - (38%)	Gaps:	44/262 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 LGDRSCIDSYRVLKELTKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTVLQL 1024
            |..:..|.....||:.....:|..:|     :|.:|..|:::  ......||::|..:|......
pombe    38 LSSKIAISKVYTLKKRIGLPESYPMK-----VLVQALIDKTV--VQNPQYSNEKLWSIGKVFGDF 95

  Fly  1025 ICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGM--------------PKYAVYANPKA 1075
            ...||:...:|...|..:..:::..:.::..:.:....|:              ...|..|:|:.
pombe    96 YVLEYIKCKYPRLPEEAVHGMQNGWMGSKALSQLATIWGLEVQRREEGLQESFGKVLAKRADPEM 160

  Fly  1076 DLKT----KDRA--DLLEAFLGALYVDKGLLYCEQFC--HVC---LFPRLQLFIMNQDWNDPKSK 1129
            ..|.    ||.|  ..:.|.||.:|:.:|....::|.  |:.   |.||..|.:   .|  |:.:
pombe   161 LRKPGEIYKDEAARRAILAILGGVYLHQGFNDTKKFINDHILSKQLDPRTMLQL---QW--PRRQ 220

  Fly  1130 LQQCCLTLRTMDGGEPDIPYYKVVEASG-PTNTRVYKVAVYFRSKRLATSSGSSIQQAEMNAAKQ 1193
            |.:.|..|...:      |.|:::..:| .:...|:.:..|.....|.....||:..||..||..
pombe   221 LSRLCKRLSLKE------PVYRIIAETGRKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYN 279

  Fly  1194 AL 1195
            :|
pombe   280 SL 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	DLL_N	64..136	CDD:289198
		Rnc	738..>974	CDD:223644	3/13 (23%)
		RIBOc	826..942	CDD:197778
		rnc	973..1196	CDD:234633	51/249 (20%)
		RIBOc	990..1117	CDD:197778	29/151 (19%)
		DSRM	1125..1196	CDD:238007	17/72 (24%)
mrpl3	NP_596672.1	Rnc	40..290	CDD:223644	53/260 (20%)
		RIBOc	65..209	CDD:197778	27/145 (19%)
		DSRM	217..285	CDD:214634	17/71 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900