Protein Alignment drosha and DICER1

DIOPT Version :10

• Sequence 1: NP_477436.1
• Gene: drosha / 35747
• FlyBaseID: FBgn0026722
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_085124.2
• Gene: DICER1 / 23405
• HGNCID: 17098
• Length: 1922
• Species: Homo sapiens
• Alignment Length: 1655
• Identity: 302/1655 - (18%)
• Similarity: 487/1655 - (29%)
• Gaps: 704/1655 - (42%)

  Fly   131 PSERQRYTS----NSSSQGYHHYPGYSSGRRYEQRHDQEHRQIQDS------------------- 172
            |.|||::.|    |:.:|  .:|..:|     :...|.|..:|::.
Human   389 PYERQQFESVEWYNNRNQ--DNYVSWS-----DSEDDDEDEEIEEKEKPETNFPSPFTNILCGII 446

  Fly   173 ----RYA-------------HEPRHGHYAHRQAKGSQHGYYGSAARN-QVSDDYSPRGHHERERN 219
                ||.             .:|...:.:.....|  ||...:..|| |:..::       |::.
Human   447 FVERRYTAVVLNRLIKEAGKQDPELAYISSNFITG--HGIGKNQPRNKQMEAEF-------RKQE 502

  Fly   220 ETLEKTRAKPKVETERDRLLRQWCSNFCEKPEDYVKKMNALSEADAPVE--SWVRSSPAELYYER 282
            |.|.|.||.     |.:.|:   .::..|:..| :.|.|.:...|.|.|  |:|:|
Human   503 EVLRKFRAH-----ETNLLI---ATSIVEEGVD-IPKCNLVVRFDLPTEYRSYVQS--------- 549

  Fly   283 TKSENEVRGRAR--LQKLCTLFDEELLQRAKRVREKLPVYVPPPRKARRRVCKHKHKSEACSSS- 344
                   :||||  :.....|.|.:   :.|...|.|..|     ||..::.::|     ||.|
Human   550 -------KGRARAPISNYIMLADTD---KIKSFEEDLKTY-----KAIEKILRNK-----CSKSV 594

  Fly   345 --SSSDDD---SDEDAF------------KIEQDCCMEELSRKVQHPQRVHADLWHNDA-----G 387
              ..:|.|   .|:|.|            ::..:..:..::|   :..|:.:|.:.:.|     .
Human   595 DTGETDIDPVMDDDDVFPPYVLRPDDGGPRVTINTAIGHINR---YCARLPSDPFTHLAPKCRTR 656

  Fly   388 EMNDG------------PL----------C----------RCSAKSRRIG-------------IR 407
            |:.||            ||          |          .|..|..:||             ::
Human   657 ELPDGTFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETVK 721

  Fly   408 H---------------GIYPGETGYKLCDPNS------------NNAGKLFHYRISISPP----T 441
            :               | .||.|..:.|.|.:            :....|:...:.::.|    .
Human   722 YEEELDLHDEEETSVPG-RPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTPLPDEL 785

  Fly   442 NFLTKTPTIIKHDEHEFLFEGFSLLSHVRLSDLPVCKVIRFNIEYTIEYEEEKMPENFTIHELDI 506
            ||..:     |....|.....|.:|:...:..:|...|...:.|.||..|.:|.....::..|::
Human   786 NFRRR-----KLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLEL 845

  Fly   507 ---FFKYLFHELLEL-------------------------------VDFNLMPN---------LP 528
               ..:|:|..:|.|                               :||..|.:         :|
Human   846 ITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIP 910

  Fly   529 SGNVEESCPAFHF----------FPR----------FVRDL----------PDNGKEVLAMVEVL 563
            |....:..| |.|          .||          :|.|:          |....|..|.....
Human   911 STKYTKETP-FVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKT 974

  Fly   564 RYLLD----NSAQL-----VERQQLL---HLNQISQSEWQNYVDFIKGMLVTKPGYKPCSLRVDQ 616
            :|.||    |...|     ..|..||   ||||             ||..:.....:....:.:.
Human   975 KYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQ-------------KGKALPLSSAEKRKAKWES 1026

  Fly   617 LDRNNSDLPE-CVDRETGISHP---AIVHFGICHPQLSY-------AGNPEYQKAWREYVKYRHL 670
            |......:|| |.      .||   ::....:|.|.:.|       |.....|.|....|..|.|
Human  1027 LQNKQILVPELCA------IHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSL 1085

  Fly   671 MANMSKPS--FKDKRKLEEKEQRLQEMRTQGRMKRNITVAISSEGFYRTGIMCDVVQHAMLIPVL 733
            .|:...|:  |..|:.::.|.                .::||:.........|   :|:.::|..
Human  1086 PADFRYPNLDFGWKKSIDSKS----------------FISISNSSSAENDNYC---KHSTIVPEN 1131

  Fly   734 TGH--------LRFHKSLD-----LLEESIGYRFKNRYLLQLALTHPSYKENYG------TNPDH 779
            ..|        |..|..:.     ||.||.|...........|:...||.:|..      .|.|.
Human  1132 AAHQGANRTSSLENHDQMSVNCRTLLSESPGKLHVEVSADLTAINGLSYNQNLANGSYDLANRDF 1196

  Fly   780 ARNSLTN-------------------------------CGIRQPEYGDRKIH--------YMNTR 805
            .:.:..|                               |.:...:|.|...:        .|...
Human  1197 CQGNQLNYYKQEIPVQPTTSYSIQNLYSYENQPQPSDECTLLSNKYLDGNANKSTSDGSPVMAVM 1261

  Fly   806 KRGINTLVSIMSRFGKEHE---------------------TVSNITHN---ERLEFLGDAVVEFL 846
            ....:|:..:..|...|..                     |:||.:..   ||||.|||:.::..
Human  1262 PGTTDTIQVLKGRMDSEQSPSIGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHA 1326

  Fly   847 SSIHLFFMFPELEEGGLATYRAAIVQNQHLALLAKKLQL-------------------------- 885
            .:.:||..:|:..||.|:..|:..|.|.:|..|.||..|
Human  1327 ITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDK 1391

  Fly   886 ------------------------------------------------EEF-------------M 889
                                                            ::|             |
Human  1392 SNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYEDDFLEYDQEHIRFIDNM 1456

  Fly   890 LYAHG-------------SDLCHELEL-------------------------------------- 903
            |...|             :|..:|.::
Human  1457 LMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFEDFDYSSWDAMCYLDPSKAVEED 1521

  Fly   904 ----------------------------------RHAMANCFEALMGALLLDGGIKVADEVF--- 931
                                              ..::|:|.|||:|..|...|.:.| ::|
Human  1522 DFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAA-QLFLCS 1585

  Fly   932 -----------TD---ALFRQDEKLLSIWKNLP------------EHPLQEQEPLGDRSCI---- 966
                       ||   ||....|...|..|||.            ...|::.|    ..|:
Human  1586 LGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVSCAAASVASSRSSVLKDSE----YGCLKIPP 1646

  Fly   967 -------DSYRVLKEL----TKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDT 1020
                   |:.:.|..|    ..||..|..:||:...|.:|||..|..:..:| ...||||||||.
Human  1647 RCMFDHPDADKTLNHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTIT-DCYQRLEFLGDA 1710

  Fly  1021 VLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANPK----------- 1074
            :|..:.:::||....:|..|.|:.|||:||||...|.:.......||....:|:
Human  1711 ILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQF 1775

  Fly  1075 -----------ADLK--------------TKDRADLLEAFLGALYVDKGLLYCEQFCHVCLFPRL 1114
                       ::|:              .|...|:.|:..||:|:|.| :..|....| .:|.:
Human  1776 QLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSG-MSLETVWQV-YYPMM 1838

  Fly  1115 QLFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGPTNTRVY----KVAVYFRSKRL 1175
            :..|.....|.|:|.:::    |..|   ||:...:...|       |.|    :|.|....|..
Human  1839 RPLIEKFSANVPRSPVRE----LLEM---EPETAKFSPAE-------RTYDGKVRVTVEVVGKGK 1889

  Fly  1176 ATSSGSSIQQAEMNAAKQALENSRDLFPQL 1205
            ....|.|.:.|:..||::||.:.:...||:
Human  1890 FKGVGRSYRIAKSAAARRALRSLKANQPQV 1919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	RIBOc	826..942	CDD:197778	44/307 (14%)
		Rnc	973..1196	CDD:440336	69/266 (26%)
DICER1	NP_085124.2	DEXHc_dicer	42..239	CDD:350792
		DECH box	175..178
		Required for interaction with PRKRA and TARBP2	256..595		55/259 (21%)
		Dicer_PBD	271..365	CDD:277191
		SF2_C_dicer	372..564	CDD:350189	43/215 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..433		5/28 (18%)
		Dicer_dimer	630..718	CDD:460900	14/90 (16%)
		PAZ_dicer_like	886..1008	CDD:239209	27/135 (20%)
		RIBOc	1296..>1387	CDD:197778	24/90 (27%)
		RIBOc	1682..1846	CDD:238333	44/166 (27%)
		DSRM_DICER	1851..1913	CDD:380680	18/75 (24%)