Protein Alignment drosha and dcr-1

DIOPT Version :10

• Sequence 1: NP_477436.1
• Gene: drosha / 35747
• FlyBaseID: FBgn0026722
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_498761.2
• Gene: dcr-1 / 176138
• WormBaseID: WBGene00000939
• Length: 1910
• Species: Caenorhabditis elegans
• Alignment Length: 1228
• Identity: 233/1228 - (18%)
• Similarity: 398/1228 - (32%)
• Gaps: 452/1228 - (36%)

  Fly   250 PEDYVK---KMNALSEADAPVESWVRSSPAELYYERTKSENEVRGRARLQKL-CTLFDEELLQRA 310
            |:|.|:   |.||....||.|..|.|:....::|...:...|.|..::.... ...|:|..::
 Worm   860 PKDEVRRQYKFNAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIK-- 922

  Fly   311 KRVREKLPVY------------------VPPPRKARRRVCKHKHKSEACSSSSSSD------DDS 351
               :.||.:|                  :.|      |:.....:|...|:||:|:      .||
 Worm   923 ---KYKLEIYDQNQSLLDVDFTSTRLNLLQP------RIQNQPRRSRTVSNSSTSNIPQASASDS 978

  Fly   352 DEDAFKIEQDCCMEELSRKVQHPQRVHADLWHNDAG---------------EMNDGPLCRCSAKS 401
            .|....:......:.|..::.....:.|.||:..|.               |:.:..|.:...|.
 Worm   979 KESNTSVPHSSQRQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLLTDELRETILVKAFGKE 1043

  Fly   402 RRIGIRHGIYPGETGYKLCDPNSNNAGKLFHYRISISPPTNFLTKTPTIIKHDEHEFLFEGFSLL 466
            :.              ||.|....|         |::..|.:..|...|:|..:
 Worm  1044 KT--------------KLDDNVEWN---------SLAYATEYEEKQTIIVKKIQ----------- 1074

  Fly   467 SHVRLSDLPVCKVIRFNIEYTIEYEEEKMPENFTIHELDIFFKYLFHELLELV------------ 519
               :|.||.         :.:||.:|.:..||..|.:.:..|.....:..|.|
 Worm  1075 ---QLRDLN---------QKSIEDQERETRENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDR 1127

  Fly   520 -------DFNLMPNLPSGNVEESCPAFHFFPRFVRDLPDNGKEVLAMVEVLRYLLDNSAQLVERQ 577
                   ...|...|..||:.:......|                       .:.|.:|:|...:
 Worm  1128 MDGEDQDTVGLTQGLHDGNISDEDDELPF-----------------------VMHDYTARLTSNR 1169

  Fly   578 QLLHL----NQISQSEWQNY---------VDFIKGMLVTKPGYKPCSLRVDQL----------DR 619
            ..:..    ..|..|.|.::         :.|   .::..||    .|.|..|          ..
 Worm  1170 NGIGAWSGSESIVPSGWGDWDGPEPDNSPMPF---QILGGPG----GLNVQALMADVGRVFDPST 1227

  Fly   620 NNSDLPECVDRETGISHPAIVHFGICHPQLSYAGNPEYQKAWREYVKYRHLMANMSKPSFKDKRK 684
            .:|.|.:.| :|:.:|.|         .||:           :|..:::.|..::.|.:   |.:
 Worm  1228 ASSSLSQTV-QESTVSPP---------KQLT-----------KEEEQFKKLQNDLLKQA---KER 1268

  Fly   685 LE--------EKEQRLQEMRTQGRMKRNITVAISSEGFYRTGIMCDVVQHAMLIPVLTGHLRFHK 741
            ||        ||.:||::           ||.:...|..:..      |.....|.     .|.|
 Worm  1269 LEALEMSEDMEKPRRLED-----------TVNLEDYGDDQEN------QEDENTPT-----NFPK 1311

  Fly   742 SLD--LLEESIGYRFKNRYLLQLALTHPSYKENYGTNP------------DHARNSLTNCGIRQP 792
            ::|  :.|.|||.|.|.......|.|....:||....|            :....::....|||
 Worm  1312 TIDEEIEELSIGARKKQEIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQ- 1375

  Fly   793 EYGDRKIHYMNTRKRGINTLVS---IMSRFGKEHETVSNITHN---ERLEFLGDAVVEFLSSIHL 851
                |...|::.....|...||   :::..     |.||....   ||.|.:||:.::|.::.:|
 Worm  1376 ----RSEEYVSHIDSDIGLGVSPCLLLTAL-----TTSNAADGMSLERFETIGDSFLKFATTDYL 1431

  Fly   852 FFMFPELEEGGLATYRAAIVQNQHLALLAKKLQLEEFMLY----AHGSDL--CH----------- 899
            :....:..||.|:..|:..|.|.:|..|.|||.:.:.::.    ||.|.|  |:
 Worm  1432 YHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCYIPTCDFKAPNT 1496

  Fly   900 --------ELE------------------------------------------------------ 902
                    |:|
 Worm  1497 DDAEEKDNEIERILDGQVIEEKPENKTGWDIGGDVSKSTTDGIETITFPKQARVGNDDISPLPYN 1561

  Fly   903 ---LRH----AMANCFEALMGALLLDGG----IKVADEVFTDALFRQDEKLLSIWKNLPEHPLQ- 955
               .:|    ::|:..|||:|..||..|    :||.:.:....: ::|:|     .::|...|:
 Worm  1562 LLTQQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVI-QKDQK-----SDVPSPLLRF 1620

  Fly   956 ---EQEPLGDRSCIDSYRVLKELTKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFL 1017
               ...|....:.:::.....:.|:.|:.||.:||....|.:|||..|.....:| |..||||||
 Worm  1621 IDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVT-GCYQRLEFL 1684

  Fly  1018 GDTVLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANP--------- 1073
            ||.||..:.:.||:....::..|.|:.|||:||||...|.:.......|:.:...|
 Worm  1685 GDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHMIEKF 1749

  Fly  1074 ------------------------------KADLKT-KDRADLLEAFLGALYVDKGLLYCEQFCH 1107
                                          :.|::. |...|:.|:..||:|:|.|
 Worm  1750 VKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSG--------- 1805

  Fly  1108 VCLFPRLQLFIMNQD--W----------------NDPKSKLQQCCLTLRTMDGGEPDIPYYKV-- 1152
                       .|.|  |                |.|:|.:::      .|:..:..:.:.|:
 Worm  1806 -----------RNLDTTWQVIFHMMRGTIELCCANPPRSPIRE------LMEFEQSKVRFSKMER 1853

  Fly  1153 VEASGPTNTRVYKVAVYFRSKRLATSSGSSIQQAEMNAAKQALENSRDLFPQLDHQKR 1210
            :..||..     :|.|...:....|..|.:.:.|:..|||:||:    ...|::.|:|
 Worm  1854 ILESGKV-----RVTVEVVNNMRFTGMGRNYRIAKATAAKRALK----YLHQIEQQRR 1902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	RIBOc	826..942	CDD:197778	39/208 (19%)
		Rnc	973..1196	CDD:440336	65/282 (23%)
dcr-1	NP_498761.2	DEXHc_dicer	11..213	CDD:350792
		Dicer_PBD	248..343	CDD:277191
		SF2_C_dicer	357..505	CDD:350189
		Dicer_dimer	571..664	CDD:460900
		PAZ_dicer_like	836..956	CDD:239209	21/106 (20%)
		RIBOc	1395..1520	CDD:197778	28/129 (22%)
		RIBOc	1659..1824	CDD:238333	43/185 (23%)
		DSRM_DICER	1832..1895	CDD:380680	15/77 (19%)