DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drosha and drsh-1

DIOPT Version :9

Sequence 1:NP_477436.1 Gene:drosha / 35747 FlyBaseID:FBgn0026722 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_492599.1 Gene:drsh-1 / 172830 WormBaseID:WBGene00009163 Length:1086 Species:Caenorhabditis elegans


Alignment Length:1131 Identity:394/1131 - (34%)
Similarity:598/1131 - (52%) Gaps:166/1131 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 HYPGYSSGRR------YEQRHDQEHRQIQDSRYAHEPRHGHYAHRQAKGSQHGYYGSAARNQVSD 206
            ::|.:...||      |::||.:|..|....|:                          :||.|.
 Worm    11 NFPKHKRARRKKYQKEYQERHKEEMMQQLGRRF--------------------------QNQPST 49

  Fly   207 DYSPRGHHERERNETLEKTRAKPKVETERDRLLRQWCSNFCEKPEDYVKKMNALSEADAPVES-- 269
            ..:|....|:....| |.|.|.|..::.|          ..||  ||  :.|.:  .|.||.|  
 Worm    50 SSAPPDTVEKIPLPT-ESTSALPFGDSPR----------LTEK--DY--ETNYM--IDPPVVSTH 97

  Fly   270 ---WVRSSPAELYYERTKSENEVRGRARLQKLCTLFDEELLQRAK---RVREKLPVYVPPPRKAR 328
               .::|:...:..|..:....::.::...|:...|..::|:..|   |::..:|..:.|....:
 Worm    98 SAELIKSNRVVIKAEEAEKYMMIKAKSTTSKILQDFQTKILETVKTKRRLQADVPYIIHPCHSMK 162

  Fly   329 -RRVCKHKHKSEACSSSSSSDD--DSDEDA------------------FKIEQDCC--------- 363
             |:..|.|...|:.::|..|||  ||.::|                  .|.|:..|         
 Worm   163 GRKTPKQKGGDESFTASDVSDDSNDSQDEASTSEPTNRQAPEADKTGEVKDEKQTCNRRNQQRKA 227

  Fly   364 -----MEE-----------LSRKVQHPQRVHADLWHNDAGEMNDGPLCRCSAKSRRIGIRHGIYP 412
                 .||           :.||..||..:|.|:..|:.|..|:||.|||....:..|::||.|.
 Worm   228 KRLRNFEEKERQITLLKKGIDRKKTHPNGIHPDISFNEKGLGNEGPECRCPEPIKTCGLKHGYYA 292

  Fly   413 GETGYKLCDPNSNNAGKLFHYRISISP-PT-NFLTKTPTIIKHDEHEFLFEGFSLLSHVRLSD-- 473
            ||.  |..|...:|...|.:|.:.::| |: |.|.:|...|..:|.|  ||||||::|..|.|  
 Worm   293 GED--KAIDCKKSNGENLHYYTLRVTPLPSENQLYRTHMAINGEEFE--FEGFSLITHAPLPDCM 353

  Fly   474 --LPVCKVIRFNIEYTIEYEEEKMP-ENFTIHELDIFFKYLFHELLELVDFNLMP-NLPSGNVEE 534
              .|:||   ::::|..:..||.|| |.|...:.|:.|:|:|||:.|::||.|.| ::||.  .|
 Worm   354 TRAPICK---YSMDYEFQLVEEFMPDECFDPEDCDMLFEYIFHEIFEMLDFELRPKHIPSD--VE 413

  Fly   535 SCPAFHFFPRFVRDLPD-----NGKEVLAMVEVLRYLLDNSAQLVERQQLLHLNQISQSEWQNYV 594
            |||..|..||||:...|     :.|.|||.     :....|::::..:.:..|......::....
 Worm   414 SCPMIHIMPRFVQTKDDLVQLWSSKTVLAY-----FTSKGSSEIMSPEDVNRLCDAQIDQFTRNT 473

  Fly   595 DFIKGMLVTKPGYKPCSLRVDQLDRNNSDLPECVDRETGISHPAI---VHFGICHPQLSYAGNPE 656
            ...|..:|....:||.::|.|..:|:..      .:|..:.|.||   .:..|..|::::     
 Worm   474 SKHKQSIVLNTKFKPSAIRADWFERDEE------KKEVYVVHNAIRAQTYTAISLPRIAF----- 527

  Fly   657 YQKAWREYVKYRHLMANMSKPSFKDKRKLEEKEQRLQEMRTQGRMKRNITVAISSEGFYRTGIMC 721
            .:|...:.::.:......:|...|.|.:||       .::.:.|..||:.:.....||..||:..
 Worm   528 LEKTLNKMIQEKQSSGVYNKDFEKTKNELE-------HLKRENRSARNLKLREPVAGFIETGLKP 585

  Fly   722 DVVQHAMLIPVLTGHLRFHKSLDLLEESIGYRFKNRYLLQLALTHPSYKENYGTNPDHARNSLTN 786
            ||..|.::..:...|:|::.|||:.||.|.|:|.:|.:::|||.|.|:|.:|||..||.:|.:||
 Worm   586 DVAAHVVMTILACHHIRYNFSLDVFEEVIEYKFNDRRVIELALMHSSFKSHYGTPIDHVKNMITN 650

  Fly   787 CGIRQPEYG--DRKIHYMNTRKR--GINTLVSIMSRFGKEHETVSNITHNERLEFLGDAVVEFLS 847
            ||.|: :||  |::     .:||  ||.:|.:||    |.......|.||||||:|||||||.:.
 Worm   651 CGYRR-KYGAEDKR-----EKKRVAGIMSLFNIM----KGTSGGEPILHNERLEYLGDAVVELIV 705

  Fly   848 SIHLFFMFPELEEGGLATYRAAIVQNQHLALLAKKLQLEEFMLYAHGSDLCHELELRHAMANCFE 912
            |.||:||.....||||||||.|:|||::||.|||..:::|.:.|:||:||.:..|.:||:||.||
 Worm   706 SHHLYFMLTHHFEGGLATYRTALVQNRNLATLAKNCRIDEMLQYSHGADLINVAEFKHALANAFE 770

  Fly   913 ALMGALLLDGGIKVADEVFTDALFRQDEKLLSIWKNLPEHPLQEQEPLGDRSCIDSYRVLKELTK 977
            |:|.|:.||||:...|.:|:.|::.....|...|.::.||.|:.::|.|||........|.....
 Worm   771 AVMAAIYLDGGLAPCDVIFSKAMYGHQPVLKEKWDHINEHELKREDPQGDRDLSFITPTLSTFHA 835

  Fly   978 FEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTVLQLICSEYLYRHFPEHHEGHL 1042
            .|:.:||:|.:|||||:|||.|:|....||.|.|||||:|||:|||||.|::|||.||.|||||:
 Worm   836 LEERLGIQFNNIRLLAKAFTRRNIPNNDLTKGHNQRLEWLGDSVLQLIVSDFLYRRFPYHHEGHM 900

  Fly  1043 SLLRSSLVNNRTQAVVCDDLGMPKYAVYANPKA-DLKTKDRADLLEAFLGALYVDKGLLYCEQFC 1106
            ||||:|||:|:||||||||||..::.:.|..|. :||.||:|||:|||:||||||:|:.:|..|.
 Worm   901 SLLRTSLVSNQTQAVVCDDLGFTEFVIKAPYKTPELKLKDKADLVEAFIGALYVDRGIEHCRAFI 965

  Fly  1107 HVCLFPRLQLFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGPTNTRVYKVAVYFR 1171
            .:...|||:.||.::.|||.||.|||.||.:|.....|||:|.|:|:...||||.|::|:|||::
 Worm   966 RIVFCPRLKHFIESEKWNDAKSHLQQWCLAMRDPSSSEPDMPEYRVLGIEGPTNNRIFKIAVYYK 1030

  Fly  1172 SKRLATSSGSSIQQAEMNAAKQALEN 1197
            .||||:::.|::.:||:..|:.||.|
 Worm  1031 GKRLASAAESNVHKAELRVAELALAN 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
droshaNP_477436.1 DLL_N 64..136 CDD:289198
Rnc 738..>974 CDD:223644 107/239 (45%)
RIBOc 826..942 CDD:197778 59/115 (51%)
rnc 973..1196 CDD:234633 120/223 (54%)
RIBOc 990..1117 CDD:197778 78/127 (61%)
DSRM 1125..1196 CDD:238007 33/70 (47%)
drsh-1NP_492599.1 RIBOc 672..793 CDD:197778 62/124 (50%)
rnc 833..1058 CDD:234633 122/224 (54%)
RIBOc 848..976 CDD:197778 78/127 (61%)
DSRM 985..1058 CDD:214634 34/72 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160158274
Domainoid 1 1.000 215 1.000 Domainoid score I1581
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H8293
Inparanoid 1 1.050 591 1.000 Inparanoid score I533
Isobase 1 0.950 - 0 Normalized mean entropy S3285
OMA 1 1.010 - - QHG48888
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003184
OrthoInspector 1 1.000 - - oto19257
orthoMCL 1 0.900 - - OOG6_101368
Panther 1 1.100 - - LDO PTHR11207
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R885
SonicParanoid 1 1.000 - - X4740
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.880

Return to query results.
Submit another query.