DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drosha and Drosha

DIOPT Version :9

Sequence 1:	NP_477436.1	Gene:	drosha / 35747	FlyBaseID:	FBgn0026722	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	XP_006520084.1	Gene:	Drosha / 14000	MGIID:	1261425	Length:	1393	Species:	Mus musculus

Alignment Length:	1356	Identity:	624/1356 - (46%)
Similarity:	833/1356 - (61%)	Gaps:	190/1356 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QPPLPPPPVQPA----------------PPPPPPPPEEDLSPPGVGVPSHNYSSNESHSQSSKSL 51
            |.||||.||:|.                ||.|||.|..: :||..|.|           ....:.
Mouse   109 QGPLPPCPVRPPYPNHQMRHPFPVPPCFPPMPPPMPCPN-NPPASGAP-----------PGQGTF 161

  Fly    52 DYVYPETPAPYASS---VPSYDPYQQPPAY-------GYEGYAYNEQAQKYGGQESHYQYQYPAS 106
            .::.|....|:...   :|....||.||.|       |:..|..|..:             :|.|
Mouse   162 PFMVPPPSMPHPPPPPVMPQQVNYQYPPGYSHSFPPPGFNSYQNNSSS-------------FPPS 213

  Fly   107 GSSFLYESYKYPDRYPAYS----SNYRPPSER------QRYTSNSSSQGYHHYP------GYSSG 155
            .:|.....:::   .|.||    .|.|...||      .|:..:|..:|..|..      |.|..
Mouse   214 ANSSSTPHFRH---LPPYSLPKAQNERRSPERLKHYDDHRHRDHSHGRGERHRSLERRERGRSPE 275

  Fly   156 R-----RYEQRHDQ------EHRQIQDSRYAHEPRHGHYAHRQAKGSQHGY---YGSAARN---- 202
            |     ||...:|:      .||..:.||.....||.|...|::...:..|   |..:.|:
Mouse   276 RRRPESRYRSDYDRGRTPPPRHRSYERSRERDRERHRHREARRSPSLERSYKKEYKRSGRSYALP 340

  Fly   203 -----------------QVSDDYSPRGHHERERNETLEKTRAKPKVETERDRLLRQWC-SNFCEK 249
                             :.::.::|...:...|:.:.||.||  :.|.|:||    |. |....|
Mouse   341 VAPEPAGCTPELPGEMIKTTESWAPPPENVNHRSPSREKKRA--RWEEEKDR----WSDSQGSGK 399

  Fly   250 PEDY--VKKMNALSEADAPVES------------WVRSSPAELYYERTK----SENEVRGRARLQ 296
            .::|  :|:..|   .:.|.|.            |:|.:.:|.||....    .::.|.|.:||:
Mouse   400 EKNYTSIKEKEA---EEVPPEKTEEEEEELLKPVWIRCTHSESYYSSDPMDQVGDSTVVGTSRLR 461

  Fly   297 KLCTLFDEELLQRAKRVREKLPVYVPPPRKARRRVCKHKHKSEACSSSSSS----DDD------S 351
            .|...|:|||..|.::.:...|.:.||..|.          .|...|||.|    |||      |
Mouse   462 DLYDKFEEELGNRQEKAKAARPPWEPPKTKL----------DEDLESSSESECETDDDSTCSSSS 516

  Fly   352 DEDAFKIEQDCCMEELSRKVQHPQRVHADLWHNDAGEMNDGPLCRCSAKSRRIGIRHGIYPGETG 416
            |.:.|.:     :.|:.||..||.|:|.:||:||.|:|||||||:||||:||.||||.|||||..
Mouse   517 DSEVFDV-----IAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEA 576

  Fly   417 YKLCDPNSNNAGKLFHYRISISPPTNFLTKTPTIIKHDEHEFLFEGFSLLSHVRLSDLPVCKVIR 481
            .|.|.|.:||||:||||||::||||||||..||:|::|:||::|||||:.:|..|:::|:|||||
Mouse   577 IKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIR 641

  Fly   482 FNIEYTIEYEEEKMPENFTIHELDIFFKYLFHELLELVDFNLMPNLPSGNVEES---CPAFHFFP 543
            |||:|||.:.||.|||||.:..|::|..:||.::|||.|:||...|    .|:|   ||.|||.|
Mouse   642 FNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPL----FEDSPPCCPRFHFMP 702

  Fly   544 RFVRDLPDNGKEVLAMVEVLRYLLDNSAQLVERQQLLHLNQISQSEWQNYVDFIKGMLVTKPGYK 608
            ||||.|||.|||||:|.::|.|||..|..||..:::.::.|..:.|||.|.:..|||:||.||.|
Mouse   703 RFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTK 767

  Fly   609 PCSLRVDQLDRNNSDLPECVDRETGISHPAIVHFGICHPQLSYAGNPEYQKAWREYVKYRHLMAN 673
            |.|:|:|||||...: ||.      |:.|.||||||...||||||:|:|||.|:.|||.|||:||
Mouse   768 PSSVRIDQLDREQFN-PEV------ITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLAN 825

  Fly   674 MSKPSFKDKRKLEEKEQRLQEMRTQGRMKRNITVAISSEGFYRTGIMCDVVQHAMLIPVLTGHLR 738
            ..|....||:||.::|:.||::|.:..|:|.:||.:||:||::|||..||.||||::||||.|:|
Mouse   826 SPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIR 890

  Fly   739 FHKSLDLLEESIGYRFKNRYLLQLALTHPSYKENYGTNPDHARNSLTNCGIRQPEYGDRKIHYMN 803
            :|:.|..|::.|||.|::|.|||||:||||:..|:|.|||||||||:|||||||:|||||:|:|:
Mouse   891 YHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMH 955

  Fly   804 TRKRGINTLVSIMSRFGKEHETVSNITHNERLEFLGDAVVEFLSSIHLFFMFPELEEGGLATYRA 868
            .||:|||||::||||.|::..|.|.|.||||||||||||||||:|:||:::||.||||||||||.
Mouse   956 MRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRT 1020

  Fly   869 AIVQNQHLALLAKKLQLEEFMLYAHGSDLCHELELRHAMANCFEALMGALLLDGGIKVADEVFTD 933
            |||||||||:|||||:|:.|||||||.|||.|.:||||||||||||:||:.|:|.::.|.::|..
Mouse  1021 AIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGR 1085

  Fly   934 ALFRQDEKLLSIWKNLPEHPLQEQEPLGDRSCIDSYRVLKELTKFEDSIGIKFKHIRLLARAFTD 998
            .|| .|..|..:|.|.|.||||.|||..||..|::..||::||:||::||:.|.|:||||||||.
Mouse  1086 LLF-NDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTL 1149

  Fly   999 RSIGFTHLTLGSNQRLEFLGDTVLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLG 1063
            |::||.|||||.|||:|||||:::||:.:|||:.|||:||||||:|||||||||||||.|.::||
Mouse  1150 RTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELG 1214

  Fly  1064 MPKYAVYANPKAD----LKTKDRADLLEAFLGALYVDKGLLYCEQFCHVCLFPRLQLFIMNQDWN 1124
            |.:||: .|.|..    |:||..|||||:|:.|||:||.|.|...|.:||.||||:.||:|||||
Mouse  1215 MQEYAI-TNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWN 1278

  Fly  1125 DPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGPTNTRVYKVAVYFRSKRLATSSGSSIQQAEMN 1189
            ||||:|||||||||| :|.|||||.||.::..||::.|.|.|||||:.:|:....|.|||||||.
Mouse  1279 DPKSQLQQCCLTLRT-EGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMG 1342

  Fly  1190 AAKQALENSRDLFPQLDHQKRVIAKSIKKQTGNELDNDSDRQHQE------EKIKR 1239
            ||..|||...  |||:.||||.|.:..:::.   .:...:|:|||      |.||:
Mouse  1343 AAMDALEKYN--FPQMAHQKRFIERKYRQEL---KEMRWEREHQEREPEEAEDIKK 1393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drosha	NP_477436.1	DLL_N	64..136	CDD:289198	19/91 (21%)
		Rnc	738..>974	CDD:223644	152/235 (65%)
		RIBOc	826..942	CDD:197778	80/115 (70%)
		rnc	973..1196	CDD:234633	140/226 (62%)
		RIBOc	990..1117	CDD:197778	82/130 (63%)
		DSRM	1125..1196	CDD:238007	43/70 (61%)
Drosha	XP_006520084.1	PRP38_assoc	<231..300	CDD:372353	16/68 (24%)
		RIBOc	978..1098	CDD:238333	81/120 (68%)
		rnc	1124..1352	CDD:234633	142/229 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834576
Domainoid	1	1.000	614	1.000	Domainoid score	I187
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8293
Inparanoid	1	1.050	1108	1.000	Inparanoid score	I230
Isobase	1	0.950	-	0	Normalized mean entropy	S3285
OMA	1	1.010	-	-		QHG48888
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003184
OrthoInspector	1	1.000	-	-		oto92038
orthoMCL	1	0.900	-	-		OOG6_101368
Panther	1	1.100	-	-	LDO	PTHR11207
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R885
SonicParanoid	1	1.000	-	-		X4740
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740