DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drosha and drosha

DIOPT Version :9

Sequence 1:NP_477436.1 Gene:drosha / 35747 FlyBaseID:FBgn0026722 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_001107152.1 Gene:drosha / 100135003 XenbaseID:XB-GENE-494685 Length:1325 Species:Xenopus tropicalis


Alignment Length:1295 Identity:619/1295 - (47%)
Similarity:814/1295 - (62%) Gaps:132/1295 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PPLPP-----------------------PPVQPAPP-PPPPPPEEDLSPPGVGVPSHNYSSNESH 44
            ||.||                       |||.|.|| .|||.|.....||        ||:.   
 Frog   104 PPAPPASAPGNPPAVVTPVGQCPYPYMMPPVMPPPPIMPPPLPHVPYQPP--------YSAG--- 157

  Fly    45 SQSSKSLDYVYP----ETPAPYASSVPSYDPYQQ--PPAYGYEGYAYNEQAQKYGGQESHYQYQY 103
                      ||    ..|.|.....||::.|||  |...|...|.:....| |..::|...::.
 Frog   158 ----------YPPQPFPPPPPSPQPTPSFNSYQQAAPSFQGNNHYRHASHGQ-YQTEKSQTDHRV 211

  Fly   104 PASGSSFLYE-----SYKYPDRYPAYSSNYR----PPSERQRYTSNSSSQGYHHYPGYSSGRRYE 159
            ...|..  ||     .|.:.||:.:...:.|    ..|||.|....|..:..:.|....|..|..
 Frog   212 QERGKH--YEDHRRREYSHSDRHRSEKHSDRRERGRSSERSRRLDGSRHRSDYEYRRGPSRGRTP 274

  Fly   160 QRHDQEHRQIQDSRYAHEPRHGHYAHRQAKGSQHGYYGSAARNQVSDDYSPRGHHERER----NE 220
            .||....|..::       ||.|...|::..::..|    .:...|...|.| .|:|.|    ||
 Frog   275 SRHPSYERSSRE-------RHRHRESRRSTSTERSY----RKRPKSPSPSSR-EHKRSRWEEDNE 327

  Fly   221 TL-EKTRAKPKVE---TERDRLLRQWCSNFCEKPEDYVKKMNALSEADAPVESWVRSSPAELYYE 281
            :| |.:.||.|..   .|:|.|.........|:.|:.:|          ||  |||.:.:|.||.
 Frog   328 SLSESSSAKEKSSISFKEKDSLDENLLERNEEEDEELLK----------PV--WVRCTHSESYYT 380

  Fly   282 RTK----SENEVRGRARLQKLCTLFDEELLQRAKRVREKLPVYVPPPRKARRRVCKHKHKSEACS 342
            ...    .::.|.|.:||:.|...|:|||.:|....|...|.:.||..|....:  .......|.
 Frog   381 SDPMDQVGDSTVVGTSRLRDLYDKFEEELGKRQATARAARPAWEPPKTKLDEDL--ESSSDSECE 443

  Fly   343 SSSSSDDDSDEDAFKIEQDCCMEELSRKVQHPQRVHADLWHNDAGEMNDGPLCRCSAKSRRIGIR 407
            :..|....||.:.|.:     :.|:.||..||.|:|.:||:||.|:|||||||:||.|:||.|||
 Frog   444 TDDSCSSSSDSEVFDV-----IAEIKRKKAHPDRLHEELWYNDPGQMNDGPLCKCSLKARRTGIR 503

  Fly   408 HGIYPGETGYKLCDPNSNNAGKLFHYRISISPPTNFLTKTPTIIKHDEHEFLFEGFSLLSHVRLS 472
            |.|||||...|.|.|.:||||:||||||::||||||||..||:|::|:||::|||||:.||..|:
 Frog   504 HSIYPGEEPIKACRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFSHSPLT 568

  Fly   473 DLPVCKVIRFNIEYTIEYEEEKMPENFTIHELDIFFKYLFHELLELVDFNLMPNLPS-GNVEESC 536
            :.|:||||||||:|||.:.||.|||:|.:..|::|..:|:.::|||.|:|||.  || .|.:.:|
 Frog   569 NFPLCKVIRFNIDYTIHFIEEMMPEHFCVKGLELFSSHLYKDILELHDWNLMD--PSVENNDANC 631

  Fly   537 PAFHFFPRFVRDLPDNGKEVLAMVEVLRYLLDNSAQLVERQQLLHLNQISQSEWQNYVDFIKGML 601
            |.|||.|||||.|||.|||||:|.:||.|||..:..||..:::.::.|..:.|||.|.:..|||:
 Frog   632 PQFHFMPRFVRFLPDGGKEVLSMHQVLLYLLRCNKSLVPEEEIANMLQWEELEWQKYAEECKGMI 696

  Fly   602 VTKPGYKPCSLRVDQLDRN--NSDLPECVDRETGISHPAIVHFGICHPQLSYAGNPEYQKAWREY 664
            ||.||.||.|:|:|||||.  |.|:         |:.|.||||||...||||||:|:|||.|:.|
 Frog   697 VTNPGMKPSSVRIDQLDREQFNPDV---------ITFPIIVHFGIRPAQLSYAGDPQYQKLWKSY 752

  Fly   665 VKYRHLMANMSKPSFKDKRKLEEKEQRLQEMRTQGRMKRNITVAISSEGFYRTGIMCDVVQHAML 729
            ||.|||:||..|....||:||.::|:.||::|.:..|:|.:||.:||:||::|||..||.||||:
 Frog   753 VKLRHLLANSPKVKQADKQKLVQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMM 817

  Fly   730 IPVLTGHLRFHKSLDLLEESIGYRFKNRYLLQLALTHPSYKENYGTNPDHARNSLTNCGIRQPEY 794
            :||||.|:|:||.|..|::.|||.|.:|.|||||:||||:..|:|.|||||||||:|||||||:|
 Frog   818 LPVLTHHIRYHKCLMHLDKLIGYIFTDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKY 882

  Fly   795 GDRKIHYMNTRKRGINTLVSIMSRFGKEHETVSNITHNERLEFLGDAVVEFLSSIHLFFMFPELE 859
            ||||:|||:.||:|||||::||||.|::..|.|.|.||||||||||||||||:|:||:::||.||
 Frog   883 GDRKVHYMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPLLE 947

  Fly   860 EGGLATYRAAIVQNQHLALLAKKLQLEEFMLYAHGSDLCHELELRHAMANCFEALMGALLLDGGI 924
            ||||||||.|||||||||:|||||:|:.|||||||.|||.|.:|||||||||||||||:.|:||:
 Frog   948 EGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALMGAVYLEGGL 1012

  Fly   925 KVADEVFTDALF-RQDEKLLSIWKNLPEHPLQEQEPLGDRSCIDSYRVLKELTKFEDSIGIKFKH 988
            :.|.::|...|| .||  |..:|.|.|.||||.||...||..|::..|||:|||||::||::|.|
 Frog  1013 EEAKQLFGRLLFGNQD--LRDVWLNYPLHPLQLQESNSDRHLIETSPVLKKLTKFEEAIGVEFTH 1075

  Fly   989 IRLLARAFTDRSIGFTHLTLGSNQRLEFLGDTVLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNR 1053
            :|||||.||.|::||.|||||.|||:|||||:::||:.:|||:.|||:||||||:||||||||||
 Frog  1076 VRLLARVFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNR 1140

  Fly  1054 TQAVVCDDLGMPKYAVYANPKAD----LKTKDRADLLEAFLGALYVDKGLLYCEQFCHVCLFPRL 1114
            |||.|.::|||.::|: .|.|..    |:||..|||||:|:.|||:||.|.|...|.:||.||||
 Frog  1141 TQAKVAEELGMQEFAI-TNDKTKRPVVLRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRL 1204

  Fly  1115 QLFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGPTNTRVYKVAVYFRSKRLATSS 1179
            :.||:|||||||||:|||||||||| :|.|||||.||.::..||::.|.|.|||||:.:|:....
 Frog  1205 KEFILNQDWNDPKSQLQQCCLTLRT-EGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGK 1268

  Fly  1180 GSSIQQAEMNAAKQALENSRDLFPQLDHQKRVIAKSIKKQTGNELDNDSDRQHQEEKIKR 1239
            |.|||||||.||..|||...  |||:.||||.|.:..:::. .||..:.::|...|::::
 Frog  1269 GPSIQQAEMGAAMDALEKYN--FPQMAHQKRFIERKYRQEL-IELRLEKEQQELAEEMRK 1325

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
droshaNP_477436.1 DLL_N 64..136 CDD:289198 21/82 (26%)
Rnc 738..>974 CDD:223644 156/236 (66%)
RIBOc 826..942 CDD:197778 83/116 (72%)
rnc 973..1196 CDD:234633 140/226 (62%)
RIBOc 990..1117 CDD:197778 80/130 (62%)
DSRM 1125..1196 CDD:238007 43/70 (61%)
droshaNP_001107152.1 Extensin_2 45..96 CDD:252669
RIBOc 914..1024 CDD:238333 82/109 (75%)
rnc 1060..1288 CDD:234633 140/231 (61%)
RIBOc 1077..1209 CDD:238333 81/135 (60%)
DSRM 1216..1287 CDD:214634 44/70 (63%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 607 1.000 Domainoid score I192
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H8293
Inparanoid 1 1.050 1102 1.000 Inparanoid score I238
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D58671at33208
OrthoFinder 1 1.000 - - FOG0003184
OrthoInspector 1 1.000 - - oto102345
Panther 1 1.100 - - LDO PTHR11207
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4740
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.160

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