DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnh1 and RNH1

DIOPT Version :9

Sequence 1:	NP_477315.1	Gene:	rnh1 / 35746	FlyBaseID:	FBgn0023171	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_013961.1	Gene:	RNH1 / 855274	SGDID:	S000004847	Length:	348	Species:	Saccharomyces cerevisiae

Alignment Length:	366	Identity:	94/366 - (25%)
Similarity:	155/366 - (42%)	Gaps:	83/366 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FYAVASGRRSGVYGSWAECEEQVKGFKNAKYKKFKTRQEADQFVN--------GCKSYAPQDVAV 74
            ||||..||.:|:|.:|.||:.||.|:..|.||||.:.::|..|:.        |..::|...|:.
Yeast     7 FYAVRKGRETGIYNTWNECKNQVDGYGGAIYKKFNSYEQAKSFLGQPNTTSNYGSSTHAGGQVSK 71

  Fly    75 PLGKEKASLASWKNSIEVNKNPKYTDEWPEEDHDLAEDDLNAAMNEVEGDPKPSNSSNLPDILN- 138
            |...:|          .|::..:     |.....|......::::....:...|..||:|:|.:
Yeast    72 PHTTQK----------RVHRRNR-----PLHYSSLTSSSACSSLSSANTNTFYSVKSNVPNIESK 121

  Fly   139 ------------RKRKGTTSGDKRNKIPRHASQVSEATGLKQVGAFQFE---IDAEGY------- 181
                        :.::|.|       ..:...|::....:..:.|..::   |..|.:
Yeast   122 IFNNWKDCQAYVKHKRGIT-------FKKFEDQLAAENFISGMSAHDYKLMNISKESFESKYKLS 179

  Fly   182 --------VIVYTDGSCIGNGRAGACAGYGVYFGKNHQLNAAKP-VEGRVTNNVGEIQAAIHAIK 237
                    :.||.|||..|||.:.:.||||.||....:.|.::| :.|..|||..||:|...|:|
Yeast   180 SNTMYNKSMNVYCDGSSFGNGTSSSRAGYGAYFEGAPEENISEPLLSGAQTNNRAEIEAVSEALK 244

  Fly   238 TALDLGIQKLC---------ISTDSQF---LINSITLW-----VAGWKKRDWKLKNNQPVKNVVD 285
            ...    :||.         |.|||::   |:|...:.     :.|....|..:...|....|..
Yeast   245 KIW----EKLTNEKEKVNYQIKTDSEYVTKLLNDRYMTYDNKKLEGLPNSDLIVPLVQRFVKVKK 305

  Fly   286 FKELDKLLQENNITVKWNYVEAHKGIEGNEMADKLARQGSA 326
            :.||:|...:||...:..:|:.|.|..||||||.||::|::
Yeast   306 YYELNKECFKNNGKFQIEWVKGHDGDPGNEMADFLAKKGAS 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnh1	NP_477315.1	Cauli_VI	19..60	CDD:279957	19/40 (48%)
rnh1	NP_477315.1	RNase_HI_eukaryote_like	183..326	CDD:260012	54/160 (34%)
RNH1	NP_013961.1	Rnh1	1..180	CDD:225878	40/194 (21%)
RNH1	NP_013961.1	RNase_HI_eukaryote_like	190..345	CDD:260012	53/158 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346263
Domainoid	1	1.000	67	1.000	Domainoid score	I2358
eggNOG	1	0.900	-	-		E1_COG0328
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	94	1.000	Inparanoid score	I1512
Isobase	1	0.950	-	0	Normalized mean entropy	S2771
OMA	1	1.010	-	-		QHG63618
OrthoFinder	1	1.000	-	-		FOG0003232
OrthoInspector	1	1.000	-	-		oto99333
orthoMCL	1	0.900	-	-		OOG6_101549
Panther	1	1.100	-	-	LDO	PTHR10642
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1165
SonicParanoid	1	1.000	-	-		X3158
TreeFam	1	0.960	-	-
	15	14.740