DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnh1 and RNASEH1

DIOPT Version :9

Sequence 1:	NP_477315.1	Gene:	rnh1 / 35746	FlyBaseID:	FBgn0023171	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_002927.2	Gene:	RNASEH1 / 246243	HGNCID:	18466	Length:	286	Species:	Homo sapiens

Alignment Length:	308	Identity:	108/308 - (35%)
Similarity:	139/308 - (45%)	Gaps:	54/308 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FYAVASGRRSGVYGSWAECEEQVKGFKNAKYKKFKTRQEADQFVNGCKSYAPQDVAVPLGKEKAS 82
            ||||..||::||:.:|.||..||..|..|::|||.|..||..||.  ||.:|:   |..|.|.
Human    28 FYAVRRGRKTGVFLTWNECRAQVDRFPAARFKKFATEDEAWAFVR--KSASPE---VSEGHEN-- 85

  Fly    83 LASWKNSIEVNKNPKYTDEWPEEDHDLAEDDLNAAMNEVEGDPKPSNSSNLPDILNRKRKGTTSG 147
              ......|...:.:..:....:.|:.||.........||..|..|..:
Human    86 --QHGQESEAKASKRLREPLDGDGHESAEPYAKHMKPSVEPAPPVSRDT---------------- 132

  Fly   148 DKRNKIPRHASQVSEATGLKQVGAFQFEIDAEGYVIVYTDGSCIGNGRAGACAGYGVYFGKNHQL 212
                                    |.:..|   :|:|||||.|..|||....||.|||:|..|.|
Human   133 ------------------------FSYMGD---FVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPL 170

  Fly   213 NAAKPVEGRVTNNVGEIQAAIHAIKTALDLGIQKLCISTDSQFLINSITLWVAGWKKRDWKLKNN 277
            |....:.||.||...||.||..||:.|....|.||.:.|||.|.||.||.||.||||..||....
Human   171 NVGIRLPGRQTNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAG 235

  Fly   278 QPVKNVVDFKELDKLLQENNITVKWNYVEAHKGIEGNEMADKLARQGS 325
            :.|.|..||..|::|.|  .:.::|.:|..|.|..|||.||:|||:|:
Human   236 KEVINKEDFVALERLTQ--GMDIQWMHVPGHSGFIGNEEADRLAREGA 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnh1	NP_477315.1	Cauli_VI	19..60	CDD:279957	20/40 (50%)
rnh1	NP_477315.1	RNase_HI_eukaryote_like	183..326	CDD:260012	68/143 (48%)
RNASEH1	NP_002927.2	Cauli_VI	29..70	CDD:279957	20/40 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..127		5/25 (20%)
		RNase_HI_eukaryote_like	141..282	CDD:260012	68/143 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159195
Domainoid	1	1.000	131	1.000	Domainoid score	I5181
eggNOG	1	0.900	-	-		E1_COG0328
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2202
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4305
Isobase	1	0.950	-	0	Normalized mean entropy	S2771
OMA	1	1.010	-	-		QHG63618
OrthoDB	1	1.010	-	-		D1434144at2759
OrthoFinder	1	1.000	-	-		FOG0003232
OrthoInspector	1	1.000	-	-		oto89299
orthoMCL	1	0.900	-	-		OOG6_101549
Panther	1	1.100	-	-	LDO	PTHR10642
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1165
SonicParanoid	1	1.000	-	-		X3158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750