DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnh1 and K12D12.5

DIOPT Version :9

Sequence 1:	NP_477315.1	Gene:	rnh1 / 35746	FlyBaseID:	FBgn0023171	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_496532.1	Gene:	K12D12.5 / 174822	WormBaseID:	WBGene00010787	Length:	648	Species:	Caenorhabditis elegans

Alignment Length:	346	Identity:	73/346 - (21%)
Similarity:	123/346 - (35%)	Gaps:	123/346 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VYGSWAECEEQ-VKGFKNAKYKKFKTRQEADQFVNGCKSYAPQDVAVPLGKEKASLASWKN--SI 90
            ||  |.|.:|: .:|..|.:...|    :||.:...|          .|.|.::     ||  .:
Worm   365 VY--WGENDEKNERGPVNMRAHAF----QADLYAAMC----------ALKKARS-----KNIRKL 408

  Fly    91 EVNKNPKYTDEWPE---EDHDLAEDDLNAAMNEVEGDPKPSNSSNLP-DILNRKRKG-------- 143
            .:....:|...|.|   :.::|..|..:..|   |......|..::. :::|...:|
Worm   409 HLLTTSEYFKNWMENVQKKNELINDRYDVMM---EFQLLLQNFESVTIEVVNSSTQGARRKMYED 470

  Fly   144 --TTSGDKRNKIPRHAS------------QVSEATGLKQVGAFQFEIDAEGYVIVYTDGSCIGNG 194
              |....:...|.:..|            .:.||..:....:.|.:       :||..|:|.|.|
Worm   471 AQTFFAGRNESIQKQRSIEDIQLEDPIENNIVEAESVNPESSNQIQ-------VVYVGGACRGRG 528

  Fly   195 RAGACAGYGVYFGKNHQLNAAKPV------EGRVTNNVGEIQAAIHAIKTAL----DLGIQKLCI 249
            .|.|.|.|.|.:          |:      :|.||..|..|:|.:.|:|:||    .|||..|.|
Worm   529 YANALAVYSVVW----------PIGEYGCSQGPVTGIVNNIRAKLAAVKSALQQAEQLGIASLII 583

  Fly   250 STDSQFLINSITLWVAGWKKRDWKLKNNQPVKNVVDFKELDKLLQENNITVKWNYVEAHKG---- 310
            .|:.|.:.:::.|             .|.|:.|:       .|:.:         :|::|.
Worm   584 RTNDQMVHDTLIL-------------QNSPIGNI-------DLMDD---------IESYKSRMRF 619

  Fly   311 ----------IEGNEMADKLA 321
                      ..||.:||:||
Worm   620 VAYQLTTGDYARGNVVADRLA 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnh1	NP_477315.1	Cauli_VI	19..60	CDD:279957	10/31 (32%)
rnh1	NP_477315.1	RNase_HI_eukaryote_like	183..326	CDD:260012	42/163 (26%)
K12D12.5	NP_496532.1	RNase_H_like	28..126	CDD:387386
		RNase_H_like	172..>233	CDD:387386
		RNase_H_like	363..456	CDD:387386	23/114 (20%)
		RNase_H_like	517..640	CDD:387386	40/161 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0328
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434144at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10642
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880