DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS12 and NaPi-T

DIOPT Version :9

Sequence 1:	NP_610332.3	Gene:	MFS12 / 35745	FlyBaseID:	FBgn0033234	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001260981.1	Gene:	NaPi-T / 36651	FlyBaseID:	FBgn0016684	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	147/502 - (29%)
Similarity:	235/502 - (46%)	Gaps:	61/502 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LLFVGMMINYFQRVNISAAIVPM-------------TQST---------------------AGAP 54
            :.|:|.::||..|:|::..||.|             ..||                     |..|
  Fly    13 MTFIGFIVNYMIRINLNITIVDMIAGKGAITSNETHENSTDLAALAEMNERFSLERWFLDWANIP 77

  Fly    55 F----YTWDTSDKSLILSSFFWGYVVSQVPAGLLAKRFGAKLVLGLATAIGGILCFFHPIAAKSG 115
            :    :.|:...:..:|.||||.:...|:|.|:||.::|.|||.|.:..||...||..||.:...
  Fly    78 YEKNGFHWNEKQQGALLGSFFWAHWTLQIPGGILATKYGTKLVFGWSNGIGVFCCFLIPIVSYWS 142

  Fly   116 WQSICVLRVLTGLVQGTVYPCVHTLLAKWVPRTERGLLTTGVYSGAQFGTAVILVTSGFIFESSM 180
            :..:.:|||..|.:.|..:|.:|.|.|||:|..||....: .|.|:..|.|:.....|:|.:.:.
  Fly   143 YTGLIILRVFQGWITGLAWPSMHVLTAKWIPPNERSKFVS-AYLGSSVGVALFYPIFGYIIDWTR 206

  Fly   181 GWPGLFYLSGGLS----LAWALLFFWQAANEPVTASRISKGEVEYIESLTGSNSSSQSMPVPWMS 241
             |..::|:.|.:.    :||..|.|...|..|    ||:..|.::||...|::......|.||.:
  Fly   207 -WEWVYYICGIVGTLWFIAWQFLVFDSPAEHP----RIADSERKFIEKSLGASIQGSKGPTPWKA 266

  Fly   242 IFRSPAFYGLLAAHCGFTWGFYTLLTEMPTYMSMVLQLNVKSNAFLSSLPYFAMGLLCFVVSPIS 306
            |..|...:..:.|..|..||.:||:|..|||..::...|:::..|||.||:....|..:|.|..:
  Fly   267 IATSRPVWLNVVAQWGGIWGLFTLMTHAPTYFRLIHHWNIRATGFLSGLPHLMRMLFAYVFSIFA 331

  Fly   307 DLLINRGTISITTARKL--FNSIGQWGPMA-CLIGLGYMTADEKTWAILLLTLAVGINAGCSCGY 368
            |.|:....:|.|..|||  |...|..|.:. .|...||    ..|.||:|:|:|..::...|.|.
  Fly   332 DYLLRTDKMSRTNVRKLATFICCGTKGLIVLALAYFGY----NATAAIVLVTVATMLHGAVSSGP 392

  Fly   369 LINHIDLSPNFAGPMMGVTNGIAGVTSIIAPLVVGAIVSDEEDPSQWRMVFFITGGIYLVCNTIF 433
            |.:.:|||||:||.::||:..|.|:...|:|.:||.:..:.:....|:.||.:|..:......::
  Fly   393 LASMVDLSPNYAGIVLGVSGMIGGMPGFISPFIVGQLTHNNQTIDAWKNVFLLTSLMLTGSGILY 457

  Fly   434 VIFGKATIQIWNE-----PPSTSSTMTLRSHQENDSKSIVP-TSDKD 474
            |:|.::.:|.||.     |.|....:......::|.:...| .||.|
  Fly   458 VLFSESKLQPWNSGCHQLPDSGLKELQNLGRDQDDEEEKKPLKSDHD 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS12	NP_610332.3	MFS	23..436	CDD:119392	136/456 (30%)
MFS12	NP_610332.3	2A0114euk	25..447	CDD:129972	140/471 (30%)
NaPi-T	NP_001260981.1	2A0114euk	1..474	CDD:129972	140/470 (30%)
NaPi-T	NP_001260981.1	MFS	76..460	CDD:119392	124/393 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	9	8.970