DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS12 and SLC17A5

DIOPT Version :9

Sequence 1:	NP_610332.3	Gene:	MFS12 / 35745	FlyBaseID:	FBgn0033234	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	433	Identity:	155/433 - (35%)
Similarity:	228/433 - (52%)	Gaps:	31/433 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KARPGGLGVRHWQAVLLFVGMMINYFQRVNISAAIVPMTQSTA--------------GAPF---- 55
            :|.|.....|:..|:|.|.|..|.|..|||:|.|:|.|..|..              .||.
Human    30 EAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHH 94

  Fly    56 ------YTWDTSDKSLILSSFFWGYVVSQVPAGLLAKRFGAKLVLGLATAIGGILCFFHPIAAKS 114
                  |.||...:..||.|||:||:::|:|.|.:|.:.|.|::||.......:|..|.||||..
Human    95 NQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADL 159

  Fly   115 GWQSICVLRVLTGLVQGTVYPCVHTLLAKWVPRTERGLLTTGVYSGAQFGTAVILVTSGFIFESS 179
            |...:.|||.|.||.:|..:|.:|.:.:.|.|..||..|.:..|:|||.||.:.|..||.|. ..
Human   160 GVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIIC-YY 223

  Fly   180 MGWPGLFYLSGGLSLAWALLFFWQAANEPVTASRISKGEVEYIESLTGSNSSSQSMPVPWMSIFR 244
            |.|..:||..|.:.:.|.||:.|..::.|....|||..|.|||.|...:..|||. .|||:.|.:
Human   224 MNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQK-SVPWVPILK 287

  Fly   245 SPAFYGLLAAHCGFTWGFYTLLTEMPTYMSMVLQLNVKSNAFLSSLPYFAMGLLCFVVS-PISDL 308
            |...:.::.||..:.|.||||||.:||||..:|:.||:.|.|||||||.. ..||.::| ..:|.
Human   288 SLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLG-SWLCMILSGQAADN 351

  Fly   309 LINRGTISITTARKLFNSIGQWGPMACLIGLGYMTADEKTWAILLLTLAVGINAGCSCGYLINHI 373
            |..:...|....|::|:.||..||...|:..|::..| .:.|:..||::..:...||.|:.|||:
Human   352 LRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCD-YSLAVAFLTISTTLGGFCSSGFSINHL 415

  Fly   374 DLSPNFAGPMMGVTNGIAGVTSIIAPLVVGAIVSDEEDPSQWR 416
            |::|::||.::|:||..|.:..::.|::..::..|.  ..|||
Human   416 DIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDA--GVQWR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS12	NP_610332.3	MFS	23..436	CDD:119392	151/419 (36%)
MFS12	NP_610332.3	2A0114euk	25..447	CDD:129972	150/417 (36%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	152/421 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148591
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840