DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS12 and SPBPB10D8.01

DIOPT Version :9

Sequence 1:	NP_610332.3	Gene:	MFS12 / 35745	FlyBaseID:	FBgn0033234	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_595045.1	Gene:	SPBPB10D8.01 / 2541399	PomBaseID:	SPBPB10D8.01	Length:	552	Species:	Schizosaccharomyces pombe

Alignment Length:	539	Identity:	100/539 - (18%)
Similarity:	196/539 - (36%)	Gaps:	161/539 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSEDKARPGGLGVRHWQ------AVLLFVGMMINYFQRVNIS-AAIVPMTQSTAGAPFYTWDTSD 62
            |.:||.       ..|:      .:|:.:.||: |..:..:| ::|:.:.:.|      ..:::.
pombe    75 PKQDKR-------LRWKLYFTVLVMLMILDMML-YIDKATLSYSSILGLFEDT------HINSNQ 125

  Fly    63 KSLILSSFFWGYVVSQVPAGLLAKRFGAKLVLGLATAIGGILCFFHPIAAKSGWQSICVLRVLTG 127
            .:.|.:.|:.|:|:.|:|..:|.:||.....:..:||:..|:.|.|  .|...:..:..||...|
pombe   126 YNDINTLFYVGFVIGQIPGHMLLQRFPVSKFVAASTALWTIIIFLH--CAAYNFSGLMALRFFLG 188

  Fly   128 LVQGTVYPCVHTLLAKWVPRTERGLLTTGVYSGAQFGTAVILVTSGFIF-------ESSMGWPGL 185
            ||:.::.|.:...:..:.|.:|:.||....|... :|..   :.:|||.       .:...|...
pombe   189 LVESSLLPTMEATIGMFFPHSEQALLQPFFYISC-YGCN---IPAGFIAYGVQYAKNTISPWKLF 249

  Fly   186 FYLSGGLSLAWAL-LFFWQAANEPVTASRISKGEVEY-IESLTGSNSS---SQSM---------- 235
            ..:.||::....: |||:...|.. ||..::|.|..| ::.:..||.|   |::.
pombe   250 MIIVGGITFFLTIGLFFYYPDNTS-TARFLTKKERLYTVDRVRRSNHSGIESKTFKKYQVIEALK 313

  Fly   236 -PVPWMSIFRSPAFYGLLAAHCGF----------------------TWGFYTLLTEMPTYMSMVL 277
             ||.|:..|.  .|...|:.:..:                      :.|:..:...:.|||..|:
pombe   314 DPVTWLFTFH--VFCNQLSNNLAYQQNLLFTSLNVSDLNSTLVGVASAGYNCVSAIIATYMMSVI 376

  Fly   278 QLNVKSNAFLSSLPYFAMGLLCFVVS---PISDLLINRGTISITTARKLFNSIGQWGPMACLIGL 339
            :.....:..:..:|..|.|:.|..:|   .|.:|          .|..:.::.|    :..:|.|
pombe   377 KNQSAFHGAIWYIPSIAGGIACVAMSWDHKIGEL----------AAIIIASNFG----IPFIISL 427

  Fly   340 GYMTADEKTWAILLLTLAVGINAGCSCGYLINHIDLSPNFAGPMMGVTNGIAGVTSIIAPLVVGA 404
            |:.||                    ||             ||....:|.|:.        .::|.
pombe   428 GWTTA--------------------SC-------------AGYTKKLTRGVM--------FMIGY 451

  Fly   405 IVSDEEDPSQWR----------------MVFFITGGIYLVCNTIFVIFGKATIQIWNEPPSTSST 453
            .:::...|..|:                :.:.::..:.|:...|.|...|..:.:
pombe   452 AIANIIGPQMWQSRDAPRYYPAWIVQIVIAWSVSPFVLLIIRWILVRRNKKRLAL---------- 506

  Fly   454 MTLRSHQENDSKSIVPTSD 472
              |..::|...|:.:.|.|
pombe   507 --LEQNKEQYEKTWIETID 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS12	NP_610332.3	MFS	23..436	CDD:119392	90/477 (19%)
MFS12	NP_610332.3	2A0114euk	25..447	CDD:129972	90/486 (19%)
SPBPB10D8.01	NP_595045.1	MFS	90..492	CDD:119392	88/472 (19%)
SPBPB10D8.01	NP_595045.1	2A0114	101..497	CDD:273326	86/465 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I2672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I1933
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16749
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.080