DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS12 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_610332.3	Gene:	MFS12 / 35745	FlyBaseID:	FBgn0033234	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	450	Identity:	134/450 - (29%)
Similarity:	224/450 - (49%)	Gaps:	16/450 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GLGVRHWQAVLLFVGMMINYFQRVNISAAIVPMTQSTA----GAP-----FYTWDTSDKSLILSS 69
            ||..|:..|::..:|..|::..|.|:..|||.|..::.    |.|     .:.||.....||..|
Human    71 GLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGS 135

  Fly    70 FFWGYVVSQVPAGLLAKRFGAKLVLGLATAIGGILCFFHPIAAKSGWQSICVLRVLTGLVQGTVY 134
            |||||:::|:|.|.::.:|.|..|.|.|..:...|..|.|.||:..:..:..:|:|.|||:|..|
Human   136 FFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTY 200

  Fly   135 PCVHTLLAKWVPRTERGLLTTGVYSGAQFGTAVILVTSGFIFESSMGWPGLFYLSGGLSLAWALL 199
            |..|.:.:||.|..||..|.|..:.|:..|..|.:..:|.:.: .:||..:||:.|...:.|.:.
Human   201 PACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQ-YIGWSSVFYIYGMFGIIWYMF 264

  Fly   200 FFWQAANEPVTASRISKGEVEYIESLTGSNSSSQSM---PVPWMSIFRSPAFYGLLAAHCGFTWG 261
            :..||...|.....||..|..|||:..|..::..|:   ..||...|.|...|.::.|:...:|.
Human   265 WLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWT 329

  Fly   262 FYTLLTEMPTYMSMVLQLNVKSNAFLSSLPYFAMGLLCFVVSPISDLLINRGTISITTARKLFNS 326
            ||.||...|.|...|....:.....||::|:..|.::..:...::|.|.:|..::.|..||:.|.
Human   330 FYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNC 394

  Fly   327 IGQWGPMACLIGLGYMTADEKTWAILLLTLAVGINAGCSCGYLINHIDLSPNFAGPMMGVTNGIA 391
            .|.......|:.:|:  :..|..||..|.||||.:.....|:.:||:|::|.:|..:||::||:.
Human   395 GGFGMEATLLLVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVG 457

  Fly   392 GVTSIIAPLVVGAIVSDEEDPSQWRMVFFITGGIYLVCNTIFVIFGKATIQIWNEPPSTS 451
            .::.::.||:||| ::..:...:|:.||.|...::......:.:|.....|.|.:|.:.|
Human   458 TLSGMVCPLIVGA-MTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLS 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS12	NP_610332.3	MFS	23..436	CDD:119392	125/424 (29%)
MFS12	NP_610332.3	2A0114euk	25..447	CDD:129972	128/433 (30%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		2A0114euk	75..513	CDD:129972	130/441 (29%)
		MFS	80..502	CDD:119392	125/425 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148609
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750