DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS12 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_610332.3	Gene:	MFS12 / 35745	FlyBaseID:	FBgn0033234	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_892004.1	Gene:	Slc17a8 / 216227	MGIID:	3039629	Length:	601	Species:	Mus musculus

Alignment Length:	450	Identity:	135/450 - (30%)
Similarity:	224/450 - (49%)	Gaps:	16/450 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GLGVRHWQAVLLFVGMMINYFQRVNISAAIVPMTQSTA----GAP-----FYTWDTSDKSLILSS 69
            |:..|:..||:..:|..|::..|.|:..|||.|..::.    |.|     .:.||.....||..|
Mouse    84 GIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGS 148

  Fly    70 FFWGYVVSQVPAGLLAKRFGAKLVLGLATAIGGILCFFHPIAAKSGWQSICVLRVLTGLVQGTVY 134
            |||||:|:|:|.|.::.:|.|..|.|.|..:...|..|.|.||:..:..:..:|:|.|||:|..|
Mouse   149 FFWGYIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYGCVMGVRILQGLVEGVTY 213

  Fly   135 PCVHTLLAKWVPRTERGLLTTGVYSGAQFGTAVILVTSGFIFESSMGWPGLFYLSGGLSLAWALL 199
            |..|.:.:||.|..||..|.|..:.|:..|..|.:..:|.:.: .:||..:||:.|...:.|.:.
Mouse   214 PACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQ-YIGWASVFYIYGMFGIIWYMF 277

  Fly   200 FFWQAANEPVTASRISKGEVEYIESLTGSNSSSQSMP---VPWMSIFRSPAFYGLLAAHCGFTWG 261
            :..||...|.....||..|..|||:..|..::..|:.   .||...|.|...|.::.|:...:|.
Mouse   278 WLLQAYECPAAHPTISNAERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWT 342

  Fly   262 FYTLLTEMPTYMSMVLQLNVKSNAFLSSLPYFAMGLLCFVVSPISDLLINRGTISITTARKLFNS 326
            ||.||...|.|...|....:.....||::|:..|.::..:...::|.|.:|..::.|..||:.|.
Mouse   343 FYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNC 407

  Fly   327 IGQWGPMACLIGLGYMTADEKTWAILLLTLAVGINAGCSCGYLINHIDLSPNFAGPMMGVTNGIA 391
            .|.......|:.:|:  :..|..||..|.||||.:.....|:.:||:|::|.:|..:||::||:.
Mouse   408 GGFGMEATLLLVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVG 470

  Fly   392 GVTSIIAPLVVGAIVSDEEDPSQWRMVFFITGGIYLVCNTIFVIFGKATIQIWNEPPSTS 451
            .::.::.||:||| ::..:...:|:.||.|...::......:.:|.....|.|.:|.:.|
Mouse   471 TLSGMVCPLIVGA-MTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLS 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS12	NP_610332.3	MFS	23..436	CDD:119392	127/424 (30%)
MFS12	NP_610332.3	2A0114euk	25..447	CDD:129972	129/433 (30%)
Slc17a8	NP_892004.1	2A0114euk	88..526	CDD:129972	132/441 (30%)
		MFS	93..515	CDD:119392	127/425 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820