DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and JADE3

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001070913.1	Gene:	JADE3 / 9767	HGNCID:	22982	Length:	823	Species:	Homo sapiens

Alignment Length:	190	Identity:	43/190 - (22%)
Similarity:	63/190 - (33%)	Gaps:	62/190 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 ASICRCRSDMVKISMETFVRRFQPERYDNWLKG-----QDMGCHPEEPGKICAAAPPTLNEYEK- 368
            ||:||...|    .|:.|           ||:.     .:|||.|.:...:    ..|:...|:
Human   133 ASVCRYDLD----DMDIF-----------WLQELNEDLAEMGCGPVDENLM----EKTVEVLERH 178

  Fly   369 -QENLRAAKSEEESPQKRGCSLAGNGCE----------RNAESAEDVD----DKASVSSYSSCRQ 418
             .||:..|...||          |.|.|          |:.:|.|..|    ||.:|..:.:|..
Human   179 CHENMNHAIETEE----------GLGIEYDEDVICDVCRSPDSEEGNDMVFCDKCNVCVHQACYG 233

  Fly   419 LQPVVK---------LRKLPTIASVPEPSSAPKRYDFNTEAVVRVKRLW---NELPCPDR 466
            :..|.:         |...|.....|:...|.|.....|:.......||   ..:.||:|
Human   234 ILKVPEGSWLCRSCVLGIYPQCVLCPKKGGALKTTKTGTKWAHVSCALWIPEVSIACPER 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224
JADE3	NP_001070913.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		EPL1	<88..177	CDD:287484	14/62 (23%)
		PHD_JADE3	202..251	CDD:277151	10/48 (21%)
		ePHD_JADE3	255..365	CDD:277176	9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..684
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..823
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900