DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kdm4A and KDM4A

DIOPT Version :9

Sequence 1:NP_610331.1 Gene:Kdm4A / 35744 FlyBaseID:FBgn0033233 Length:495 Species:Drosophila melanogaster
Sequence 2:NP_055478.2 Gene:KDM4A / 9682 HGNCID:22978 Length:1064 Species:Homo sapiens


Alignment Length:506 Identity:248/506 - (49%)
Similarity:334/506 - (66%) Gaps:55/506 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 EEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNINMTIP 74
            |..|...|||||.|:.|||:|||.||.||||:|||.|||||:.||.||.||.|..|||  ::.||
Human     6 ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDID--DLVIP 68

  Fly    75 APICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLY 139
            |||.|:|||..|::.|.|| |::.||:|:|.:.|||:.:.|||:.::::||||||||:|:..|:|
Human    69 APIQQLVTGQSGLFTQYNI-QKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIY 132

  Fly   140 AADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSI 204
            .|||.|:|.::.:|.||||||.|||:||..:..|.|:||||.||||||||:||||||||||||||
Human   133 GADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSI 197

  Fly   205 NYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQ 269
            ||||||.||:||::||.:|:|||:||...|..:.|.|.|:||||||:|||.:|:::.||::|:||
Human   198 NYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQ 262

  Fly   270 EAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPE 334
            ||||.|||||:|||||||||||.|||||||::|||||||:|.:|.||.|||||||:.|||:||||
Human   263 EAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPE 327

  Fly   335 RYDNWLKGQDMGCHPEEPGKICAAAP-PTLNEYEKQENL-RAAKSEEESPQKRGCSLAGNGCERN 397
            ||..|..|:|...       |....| |...|:.|:..| ..|.:|||.|::   .:.|      
Human   328 RYKLWKAGKDNTV-------IDHTLPTPEAAEFLKESELPPRAGNEEECPEE---DMEG------ 376

  Fly   398 AESAEDVDDKASVSS-------YSSCRQLQPVVKLRKLPTIASVPEPSSAPKRYDFNTE-----A 450
            .|..|:.|.|.|::.       :..|.::...|...:|     .|:...:.::|:. ||     |
Human   377 VEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSEL-----FPKEDLSSEQYEM-TECPAALA 435

  Fly   451 VVR-----VKRLWNELPCPDRGANLLTNGVVKNTKRMRF-QTKVLTLDDED 495
            .||     |:::.:.|..||          ..::..::| :.|.:.|::||
Human   436 PVRPTHSSVRQVEDGLTFPD----------YSDSTEVKFEELKNVKLEEED 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kdm4ANP_610331.1 JmjN 17..59 CDD:301729 30/41 (73%)
JmjC 182..298 CDD:202224 83/115 (72%)
KDM4ANP_055478.2 JmjN 13..55 CDD:128818 30/41 (73%)
JmjC 175..291 CDD:202224 83/115 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 358..384 9/34 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..537
Interaction with NCOR1. /evidence=ECO:0000269|PubMed:16024779 597..638
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..641
PHD_JMJD2A 667..766 CDD:277050
ePHD_JMJD2A 775..884 CDD:277183
TUDOR 897..953 CDD:197660
TUDOR 955..1010 CDD:197660
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 210 1.000 Domainoid score I2814
eggNOG 1 0.900 - - E1_COG5141
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 475 1.000 Inparanoid score I1496
Isobase 1 0.950 - 0 Normalized mean entropy S2611
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1186832at2759
OrthoFinder 1 1.000 - - FOG0000582
OrthoInspector 1 1.000 - - mtm8529
orthoMCL 1 0.900 - - OOG6_100918
Panther 1 1.100 - - O PTHR10694
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2594
SonicParanoid 1 1.000 - - X490
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.810

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