DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and RPH1

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_011096.1	Gene:	RPH1 / 856916	SGDID:	S000000971	Length:	796	Species:	Saccharomyces cerevisiae

Alignment Length:	535	Identity:	170/535 - (31%)
Similarity:	259/535 - (48%)	Gaps:	121/535 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKS-GYDIDNI-NMTIPAPICQV 80
            :..|:|:||:|::|.||.:.|...|.. :|:.|:.||.||..:.. .|..:.: .:.|.:||.|.
Yeast    14 VPVFKPTYEQFEDFYAYCKAINKYGMK-SGVVKVIPPKEWKDKLDLPYSAETLQKIKIKSPIQQH 77

  Fly    81 VTGAHGVYQQINIQQRRQMTLRQFME-------------KANS-----------ELHQTPRHFDY 121
            ::|..|::...|:::.:...:.|:.:             :.||           :|......|:.
Yeast    78 ISGNKGLFMVQNVEKNKTYNIIQWKDLSKDYVPPEDPKARRNSRKGSVSKSTKLKLKNFESSFNI 142

  Fly   122 DD-----------------------LERKYWKNITYISPLYAADVKGSLSDEDLDVWNIGRLDTI 163
            ||                       ||..|||.:.:.:|:|.||..||:..|.|:|||:.:|..|
Yeast   143 DDFEQFRTEYTIDLSDFQNTERLKFLEEYYWKTLNFTTPMYGADTPGSIFPEGLNVWNVAKLPNI 207

  Fly   164 LNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEK 228
            |:.:.|.    :.|||.:|||.|:||:||:||.||.|||||||:||||||.||:||.....:..|
Yeast   208 LDHMETK----VPGVNDSYLYAGLWKASFSWHLEDQDLYSINYIHFGAPKQWYSIPQEDRFKFYK 268

  Fly   229 LANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGA 293
            ...|.|.|..:.|..:|||||.:.|||:|:::.|..|:|....||.|||:|:|||||||:|:|.|
Yeast   269 FMQEQFPEEAKNCPEFLRHKMFLASPKLLQENGIRCNEIVHHEGEFMITYPYGYHAGFNYGYNLA 333

  Fly   294 ESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPERYDNWLKGQDMGCHP--EEPGKIC 356
            ||.|||.:.|:..||:|..|.|.||.|:|.::...:.::    ||  ..:..|..|  :.|.
Yeast   334 ESVNFALEEWLPIGKKAGKCHCISDSVEIDVKKLAKSWR----DN--NKESKGTPPLNQLPN--- 389

  Fly   357 AAAP----PTLNEYEKQENLRAAKSEEESPQKRGCSLAGNGCERNAESAEDVDDKASVSSYSSCR 417
            .|.|    |||.|.| ..:||:.     ||                    ||...::..|.|| .
Yeast   390 PAMPLLHRPTLKEME-SSSLRST-----SP--------------------DVGHFSNFKSKSS-G 427

  Fly   418 QLQPVVKLRKLPTIASVPEPSSAPKRYDFNTEAVVRVKRL--WNELPCPDRGANLLTNGVVKNTK 480
            ...|:  |.::...:::.||:.        .:..:::||:  :.|.|            :.|..|
Yeast   428 VSSPL--LSRMKDYSNIVEPTL--------EDPTLKLKRISSFQEQP------------LNKLLK 470

  Fly   481 RMRFQTKVLTLDDED 495
            |...||.:|| |.||
Yeast   471 RETSQTAMLT-DHED 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	16/40 (40%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	64/115 (56%)
RPH1	NP_011096.1	JmjN	13..54	CDD:128818	16/40 (40%)
		JmjC	222..338	CDD:396791	64/115 (56%)
		COG5048	507..>759	CDD:227381
		C2H2 Zn finger	711..732	CDD:275368
		C2H2 Zn finger	740..757	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I903
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm9190
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
TreeFam	1	0.960	-	-
	10	9.800