DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and SNT2

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_011384.1	Gene:	SNT2 / 852746	SGDID:	S000003099	Length:	1403	Species:	Saccharomyces cerevisiae

Alignment Length:	272	Identity:	50/272 - (18%)
Similarity:	91/272 - (33%)	Gaps:	87/272 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 GRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEAGEIMITFPFGYHAGFN 287
            |.:..|..|:||..        ||:.:.:::.| |.::|.|..|..:...:|.::.|....
Yeast   928 GFKFVKFDNKTFQR--------LRNSLKLVNNK-LPKYNEPSTKKIKMINDIALSNPLNEP---- 979

  Fly   288 HGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPERYDNWLKGQDMGCHPEEP 352
               ||| |.|:..   |.:.|..|:..                   |:|.:..|          |
Yeast   980 ---NGA-SYNYTV---ISHSKETSVAL-------------------EKYHDGNK----------P 1008

  Fly   353 GKICAAAPPTLNEYEKQENLRAAKSEEESPQ--------KRGCSLAGNGCERNAESAEDVDDKAS 409
            .|:          .||...|:..|::.::|.        :..||:.......| ::.|.|.....
Yeast  1009 SKM----------LEKDMILKHTKNKPKNPDTAWANNSARTFCSVCKEKFNDN-DNYEVVCGNCG 1062

  Fly   410 VSSYSSCRQLQPVVKLRK------------------LPTIASVPEPSSAP-KRYDFNTEAVVRVK 455
            ::.:..|..::....::|                  .|.|::..:.|..| |.||::.......|
Yeast  1063 LTVHYFCYAIKLPKDMKKNTNLKTFKWLCDPCSNDLNPIISTTYQCSMCPTKDYDYDRYRSQSFK 1127

  Fly   456 RLWNELPCPDRG 467
            ...:.|.|...|
Yeast  1128 ICPDALKCTSLG 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	18/74 (24%)
SNT2	NP_011384.1	BAH_fungalPHD	112..256	CDD:240061
		PHD1_Snt2p_like	319..366	CDD:276972
		Myb_DNA-binding	559..602	CDD:395191
		PHD2_Snt2p_like	1040..1094	CDD:276973	7/54 (13%)
		ePHD_Snt2p_like	1108..1248	CDD:277137	9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900