Protein Alignment Kdm4A and GIS1

DIOPT Version :10

• Sequence 1: NP_610331.1
• Gene: Kdm4A / 35744
• FlyBaseID: FBgn0033233
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_010381.1
• Gene: GIS1 / 851670
• SGDID: S000002503
• Length: 894
• Species: Saccharomyces cerevisiae
• Alignment Length: 517
• Identity: 132/517 - (25%)
• Similarity: 200/517 - (38%)
• Gaps: 90/517 - (17%)

  Fly    18 IMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNINMTI--PAPICQV 80
            :..|:||..||.||..:|:.|...|.. .|:.|:.||.||:....|........||  .:||.|.
Yeast    12 VPVFKPSMMEFANFQYFIDEITKFGIE-NGIVKVIPPKEWLELLEGSPPAESLKTIQLDSPIQQQ 75

  Fly    81 V----TGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDD------------------ 123
            .    ...:||:...|....:...|.|:...|.| |.......|::|
Yeast    76 AKRWDKHENGVFSIENEYDNKSYNLTQWKNLAES-LDSRISQGDFNDKTLKENCRVDSQQDCYDL 139

  Fly   124 -----LERKYWKNITYISPLYAADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYL 183
                 ||..:||.|.:..|.||.|...|:...||.:||:..|...:|..|            ..|
Yeast   140 AQLQILESDFWKTIAFSKPFYAVDENSSIFPYDLTLWNLNNLPDSINSSN------------RRL 192

  Fly   184 YFGMWKSSFAWHTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHK 248
            ..|..|..|.||.::.:..|||||||||||.||:||.|...:..|:.::..|.|.:.|.|::||:
Yeast   193 LTGQSKCIFPWHLDEQNKCSINYLHFGAPKQWYSIPSANTDQFLKILSKEPSSNKENCPAFIRHQ 257

  Fly   249 MTMISPKVLRQHNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASIC 313
            ..:.||..||::||.:|::.|...|.:||||:..::|||:|:|..||..|...:.....|:...|
Yeast   258 NIITSPDFLRKNNIKFNRVVQFQHEFIITFPYCMYSGFNYGYNFGESIEFILDQQAVVRKQPLKC 322

  Fly   314 RCR-----------SDMVKISMETFVR---------RFQPER-YDNWLKGQDMGCHPEEPGKICA 357
            .|.           |::...|.|:..|         .||..| :|..|.      |..:
Yeast   323 GCGNKKEERKSGPFSNLSYDSNESEQRGSITDNDNDLFQKVRSFDELLN------HSSQ------ 375

  Fly   358 AAPPTLNEYEKQENLRAAKSEEESPQKRGC-SLAGNGCERNAESAEDVDDKASVSSYSSCRQLQP 421
                .|...|..:|...:......||.... |...||..:.....:....:.|....|....|..
Yeast   376 ----ELQNLEDNKNPLFSNINMNRPQSSSLRSTTPNGVNQFLNMNQTTISRISSPLLSRMMDLSN 436

  Fly   422 VV---------KLRKLPTIASVPEPSSAPKRYDFNTEAVVRVKRLWNELPCPDRGANLLTNG 474
            :|         |.::......:|:.:......:|.|.::.....|.:.:.......:..|||
Yeast   437 IVEPTLDDPGSKFKRKVLTPQLPQMNIPSNSSNFGTPSLTNTNSLLSNITATSTNPSTTTNG 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:472837	16/40 (40%)
		JmjC	182..298	CDD:396791	49/115 (43%)
GIS1	NP_010381.1	JmjN	11..52	CDD:128818	16/40 (40%)
		JmjC	191..307	CDD:396791	49/115 (43%)
		PHA00733	<828..879	CDD:177301
		zf-C2H2_4	828..851	CDD:464025
		C2H2 Zn finger	830..851	CDD:275368
		C2H2 Zn finger	859..876	CDD:275368