DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and JMJ18

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001185118.1	Gene:	JMJ18 / 839963	AraportID:	AT1G30810	Length:	819	Species:	Arabidopsis thaliana

Alignment Length:	481	Identity:	132/481 - (27%)
Similarity:	191/481 - (39%)	Gaps:	132/481 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DEEQ----NKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVP-----RKSGY 64
            ||.|    |..|   .|.||.|||.:..||||.|... |...|:.:|.||:.|.|     .||.:
plant    49 DEAQRPIINDAP---VFTPSLEEFVDPLAYIEKIRPL-AEPYGICRIIPPSTWKPPCRLKEKSIW 109

  Fly    65 D-------IDNINM--------------------------------TIPAPICQVVTGAHGVYQQ 90
            :       |..:::                                :.||.    .|.:....::
plant   110 EQTKFPTRIQTVDLLQNREPMKKKPKSRKRKRRRNSRMGSSKRRSGSSPAE----STSSPEAEEK 170

  Fly    91 INIQQRRQMTLRQFMEKANSELHQTPRHFD--------------YDDLERKYWKNITY----ISP 137
            .........||.:|.:.|   ||....:|:              .||:|.:||:.:..    :..
plant   171 FGFNSGSDFTLDEFEKYA---LHFKDSYFEKKDSGGDIVKWTPSVDDIEGEYWRIVEQPTDEVEV 232

  Fly   138 LYAADVKGSL--------------SDED---LDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYF 185
            .|.||::..:              ||.:   |..||:..|..:...|.:..:..|.||...:||.
plant   233 YYGADLENGVLGSGFYKRAEKFTGSDMEQYTLSGWNLNNLPRLPGSVLSFEDCDISGVLVPWLYV 297

  Fly   186 GMWKSSFAWHTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMT 250
            ||..|||.||.||..|||:||.|||.||.||.:|.:....|||...:...:.::|....|...:|
plant   298 GMCFSSFCWHVEDHHLYSLNYHHFGEPKVWYGVPGSNATALEKAMRKHLPDLFEEQPDLLHGLVT 362

  Fly   251 MISPKVLRQHNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRC 315
            ..||.:|:...:...::.|.:||.::|||..||||||.|||.||:.|.|...|:.:|:.|
plant   363 QFSPSILKDEGVQAYRVVQNSGEYVLTFPRAYHAGFNCGFNCAEAVNVAPVDWLAHGQNA----- 422

  Fly   316 RSDMVKI-SMETFVRRFQPERYDNWLKGQDMGCHPEEPGKICAAAPPTLNEYEKQE---NLRAAK 376
                |:: |.||   |.....:|..|.|               ||      ||..:   .|.|::
plant   423 ----VELYSKET---RKTSLSHDKLLLG---------------AA------YEAVKALWELSASE 459

  Fly   377 SEEESPQKRGCSLAG-NGCERNAESA 401
            .:|.:...|..|..| ||...||..|
plant   460 GKENTTNLRWKSFCGKNGTLTNAIQA 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	17/41 (41%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	50/115 (43%)
JMJ18	NP_001185118.1	JmjN	59..99	CDD:128818	18/43 (42%)
		JmjC	294..410	CDD:396791	50/115 (43%)
		zf-C5HC2	519..571	CDD:397190
		FYRN	658..702	CDD:128814
		FYRC	708..794	CDD:197781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I2177
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.920