DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and MEE27

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_181034.1	Gene:	MEE27 / 818053	AraportID:	AT2G34880	Length:	806	Species:	Arabidopsis thaliana

Alignment Length:	507	Identity:	133/507 - (26%)
Similarity:	203/507 - (40%)	Gaps:	132/507 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ADEEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVP--RKSGYDIDNI- 69
            |:|::..:.....|.|:.|||::..||||.|... |...|:.:|.||:.|.|  |..|   |:|
plant    51 ANEKRPDIGEAPVFHPTSEEFEDTLAYIEKIRPL-AESFGICRIVPPSNWSPPCRLKG---DSIW 111

  Fly    70 -NMTIPAPICQVV-----------------TGAHGVYQQINIQQRR------------------- 97
             |...|..: |.|                 ....|.|.:....::|
plant   112 KNKNFPTRV-QFVDLLQNRGPVKKKTPKGRKRKRGKYSRTVAPKKRNGSVSKSVSTPKATEEENF 175

  Fly    98 ------QMTLRQFMEKANSELHQTPRHFD---------YDDLERKYW----KNITYISPLYAADV 143
                  :.||.:| ||...:...:  :|:         .:::|.:||    |....:..||..|:
plant   176 GFESGPEFTLEKF-EKYAQDFKDS--YFERKDNVGDPSVEEIEGEYWRIIEKETNEVKVLYGTDL 237

  Fly   144 KGSL---------------SDEDLDV---WNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKS 190
            :..:               :|.|..:   ||:..|..:...:.:..:..|.||...:||.||..|
plant   238 ENPILGSGFSKGVKIPTRRNDMDKYISSGWNLNNLARLQGSLLSFEDCEISGVQVPWLYVGMCFS 302

  Fly   191 SFAWHTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPK 255
            :|.||.||..|||:||.|||.||.||.:|.::...|||...:...:.:.|....|...:|..||.
plant   303 TFCWHVEDNHLYSLNYHHFGEPKVWYGVPGSHATGLEKAMRKHLPDLFDEQPDLLHELVTQFSPT 367

  Fly   256 VLRQHNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMV 320
            :|:...:|..:..|.|||.::|||..||:|||.|||.||:.|.|...|:.:|:.|         |
plant   368 ILKNEGVPVYRAVQNAGEYVLTFPRAYHSGFNCGFNCAEAVNVAPVDWLAHGQNA---------V 423

  Fly   321 KI-SMETFVRRFQPERYDNWLKG------QDMGCHPEE-------------PGKICAAAPPTLNE 365
            :| |.||   |.....:|..|.|      :.:..|.|:             .|.|..|....|..
plant   424 EIYSQET---RKTSLSHDKILLGAAFEAVKSLSAHGEDNTKRFSWKRFCGKDGIITKAIEARLRM 485

  Fly   366 YEKQ-----ENLRAAKSEE--ESPQKRGC-------SLAGNGCERNAESAED 403
            .||:     ......|.::  :|..:|.|       .|:..|| :|..|.|:
plant   486 EEKRIEALGNGFSLVKMDKDFDSNCERECISCFSDLHLSATGC-KNCSSLEE 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	16/41 (39%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	50/115 (43%)
MEE27	NP_181034.1	JmjN	60..101	CDD:128818	16/41 (39%)
		JmjC	294..410	CDD:202224	50/115 (43%)
		zf-C5HC2	514..566	CDD:280996	7/24 (29%)
		FYRN	643..687	CDD:128814
		FYRC	693..781	CDD:197781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I2177
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.920