DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and Brpf1

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_006506845.1	Gene:	Brpf1 / 78783	MGIID:	1926033	Length:	1253	Species:	Mus musculus

Alignment Length:	465	Identity:	82/465 - (17%)
Similarity:	134/465 - (28%)	Gaps:	199/465 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 QQINIQQ-RRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLYAADVKGSLSDEDL 152
            :.|.||| ..:|.|..|:......|.|         |:.|              |. |::..|.:
Mouse   616 ETIKIQQIAMEMQLTPFLILLRKTLEQ---------LQEK--------------DT-GNIFSEPV 656

  Fly   153 DVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWH-------TEDMDLYSINYLHFG 210
            .:..:..||.:     .||   :|.:.....:|.|.::..|:.       .||.:|...|.|.:.
Mouse   657 PLSEVTELDEV-----PDY---LDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYN 713

  Fly   211 APKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEAGEIM 275
            |..|      .:.|...:|..:                    ...||||       ..::|.::.
Mouse   714 AKDT------IFYRAAVRLREQ--------------------GGAVLRQ-------ARRQAEKMG 745

  Fly   276 ITFPFGYHAGFN--------HGFNGAESTNF--------------------------ASKRWIEY 306
            |.|..|.|...|        |..:..|....                          |||:.:..
Mouse   746 IDFETGMHIPHNLAGDEVSHHTEDAVEEERLVLLENQKHLPVEEQLKLLLERLDEVNASKQSVGR 810

  Fly   307 GKRASICRCRSDMVKISMETFVRRFQPERYDNWLKGQDMGCHPEEPGKICAAAPPTLNEYEKQEN 371
            .:||.       |:|..|....|:.               .|..|.|:
Mouse   811 SRRAK-------MIKKEMTALRRKL---------------AHQRETGR----------------- 836

  Fly   372 LRAAKSEEESPQKRGCSLAGN------GCERNAESAEDVDDKASVSSYSSCRQLQP--------- 421
                    :.|::.|.|..||      .|:::.::....::.   ||..:.:.|.|
Mouse   837 --------DGPERHGPSGRGNLTPHPAACDKDGQTDSAAEES---SSQETSKGLGPNMSSTPAHE 890

  Fly   422 ------VVKLRKLPTIASVPE-PSSAPKRYDFNTEAVVRVKRLWNELPCPDRGAN------LLTN 473
                  |:..:|.|..|..|: |...||    |.|:.:          .|..|.:      |...
Mouse   891 VGRRTSVLFSKKNPKTAGPPKRPGRPPK----NRESQM----------TPSHGGSPVGPPQLPIM 941

  Fly   474 GVVKNTKRMR 483
            |.::..||.|
Mouse   942 GSLRQRKRGR 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	24/130 (18%)
Brpf1	XP_006506845.1	SFP1	<20..50	CDD:227516
		COG5141	173..656	CDD:227470	14/63 (22%)
		ePHD_BRPF1	329..449	CDD:277171
		Bromo_brd1_like	631..734	CDD:99944	25/160 (16%)
		BR140_related	1122..1237	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900