DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and BRPF1

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_024309509.1	Gene:	BRPF1 / 7862	HGNCID:	14255	Length:	1254	Species:	Homo sapiens

Alignment Length:	411	Identity:	78/411 - (18%)
Similarity:	127/411 - (30%)	Gaps:	165/411 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 QQINIQQ-RRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLYAADVKGSLSDEDL 152
            :.|.:|| ..:|.|..|:......|.|         |:.|              |. |::..|.:
Human   617 ETIKVQQIAMEMQLTPFLILLRKTLEQ---------LQEK--------------DT-GNIFSEPV 657

  Fly   153 DVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWH-------TEDMDLYSINYLHFG 210
            .:..:..||.:     .||   :|.:.....:|.|.::..|:.       .||.:|...|.|.:.
Human   658 PLSEVTELDEV-----PDY---LDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYN 714

  Fly   211 APKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEAGEIM 275
            |..|      .:.|...:|..:                    ...||||       ..::|.::.
Human   715 AKDT------IFYRAAVRLREQ--------------------GGAVLRQ-------ARRQAEKMG 746

  Fly   276 ITFPFGYHAGFNHGFNGAESTNF------------------------------------ASKRWI 304
            |.|..|.|  ..|...|.|:|:.                                    |||:.:
Human   747 IDFETGMH--IPHSLAGDEATHHTEDAAEEERLVLLENQKHLPVEEQLKLLLERLDEVNASKQSV 809

  Fly   305 EYGKRASICRCRSDMVKISMETFVRRFQ---------PERYDNWLKGQDMGCHP---EEPGKICA 357
            ...:||.       |:|..|....|:..         |||:....:| .:..||   ::.|:..:
Human   810 GRSRRAK-------MIKKEMTALRRKLAHQRETGRDGPERHGPSSRG-SLTPHPAACDKDGQTDS 866

  Fly   358 AAPPTLNEYEKQENLRAAKSEEESPQKRGCSLAGNGCERNAESAEDVDDKASVSSYSSCRQLQPV 422
            ||                  ||.|.|:   :..|.|...::..|.:|..:.|            |
Human   867 AA------------------EESSSQE---TSKGLGPNMSSTPAHEVGRRTS------------V 898

  Fly   423 VKLRKLPTIASVPE-PSSAPK 442
            :..:|.|..|..|: |...||
Human   899 LFSKKNPKTAGPPKRPGRPPK 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	25/122 (20%)
BRPF1	XP_024309509.1	SFP1	<20..52	CDD:227516
		COG5141	174..657	CDD:227470	13/63 (21%)
		ePHD_BRPF1	330..450	CDD:277171
		Bromo_brd1_like	632..735	CDD:99944	25/160 (16%)
		BR140_related	1123..1238	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900