DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and Jade2

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001344517.1	Gene:	Jade2 / 76901	MGIID:	1924151	Length:	901	Species:	Mus musculus

Alignment Length:	171	Identity:	29/171 - (16%)
Similarity:	56/171 - (32%)	Gaps:	47/171 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 TNFASKRWIEYGKRASICR-CRSDMVKISMETFVRRFQPERYDNWLKGQDMGCHPEEPGKICAAA 359
            ::..:.||   ....|:|: |....::.||.:.:..|.                     ..||
Mouse   372 SHIPASRW---ALSCSLCKECTGTCIQCSMPSCITAFH---------------------VTCA-- 410

  Fly   360 PPTLNEYEKQENLRAAKSE-EESPQKRGCSLAGNGCERNAESAEDVDDKASVSSYSSCRQLQPVV 423
                  :::...:|...:: :|...|..|....:|..|:..::|.|:...:|.....       |
Mouse   411 ------FDRGLEMRTILADNDEVKFKSLCQEHSDGGPRSEPTSEPVEPSQAVEDLEK-------V 462

  Fly   424 KLRKL------PTIASVPEPSSAPKRYDFNTEAVVRVKRLW 458
            .|||.      .....:.||:...:|.|.....|..:.:.|
Mouse   463 TLRKQRLQQLEENFYELVEPAEVAERLDLAEALVDFIYQYW 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	0/1 (0%)
Jade2	NP_001344517.1	EPL1	209..>578	CDD:331339	29/171 (17%)
		ePHD_JADE2	326..436	CDD:277175	14/95 (15%)
		Atrophin-1	<676..852	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900