DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and Kdm4d

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001073180.1	Gene:	Kdm4d / 689582	RGDID:	1591045	Length:	510	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	232/492 - (47%)
Similarity:	294/492 - (59%)	Gaps:	55/492 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTRSSFADEEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYD 65
            |.|:|:.|   ||....||.|||:.|||.:|..||.|:||:|||.|||||:.||.||..|:|
  Rat     1 MKTKSTCA---QNPNCSIMIFRPTKEEFNDFDKYIAYMESQGAHRAGLAKVIPPKEWRARQS--- 59

  Fly    66 IDNI-NMTIPAPICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYW 129
            .||| |:.|..|:.|||:|..||:.|.: ::::.||:.|:...|||:.:|||.|.|::|||||||
  Rat    60 YDNISNILIATPLQQVVSGQAGVFTQYH-KKKKAMTVGQYRHLANSKKYQTPPHLDFEDLERKYW 123

  Fly   130 KNITYISPLYAADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAW 194
            ||..|.||:|.|||.|||.|.....||:|.|.||.:|:..:..|:|:||||.||||||||:||||
  Rat   124 KNRLYESPIYGADVSGSLFDGKTQQWNVGHLGTIQDLLEQECGIVIEGVNTPYLYFGMWKTSFAW 188

  Fly   195 HTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQ 259
            ||||||||||||||||.||||||:||.:|||||.||.|.|..:.|.|.|:||||:.:|||.||::
  Rat   189 HTEDMDLYSINYLHFGQPKTWYAVPPEHGRRLELLAKELFPGSSQGCQAFLRHKVALISPTVLKE 253

  Fly   260 HNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISM 324
            :.||:.:|||||||.|:|||:|||||||||||.||:.|||:.|||:|||.||.|.|....|..||
  Rat   254 NGIPFGRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVSFSM 318

  Fly   325 ETFVRRFQPERYDNWLKGQDMGC--HPEEPGKICAAAPPTLNEY---------EKQENLRAAKSE 378
            :.|||..|||||:.|.:|||...  |.|..|       ||..|.         .|...|:..:..
  Rat   319 DAFVRILQPERYEMWKRGQDQAVVDHTEAMG-------PTSQELTTWRVIQAPRKTWGLKHLRLR 376

  Fly   379 EES----PQKRGCSLAGNG--CERNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEP 437
            :.|    |.....::|.|.  |..:.::|:...|:...|.                |.||. |.|
  Rat   377 QVSRCLLPVATDSNIANNTQMCHTSRQAADSKGDEVQESD----------------PAIAP-PYP 424

  Fly   438 SSAPKRYDFNTEAVVRVKRLWNELPCPDRGANLLTNG 474
            .........:|.     ||.....|| :.|....|||
  Rat   425 LGLSSPGHMSTG-----KRGLGRRPC-ELGVQESTNG 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	26/41 (63%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	83/115 (72%)
Kdm4d	NP_001073180.1	JmjN	15..55	CDD:128818	25/39 (64%)
		JmjC	176..292	CDD:202224	83/115 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..510		18/82 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2717
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	436	1.000	Inparanoid score	I1637
OMA	1	1.010	-	-		QHG58782
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm9003
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.840