DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and Brpf1

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_006237117.1	Gene:	Brpf1 / 679713	RGDID:	1584828	Length:	1252	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	82/466 - (17%)
Similarity:	135/466 - (28%)	Gaps:	202/466 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 QQINIQQ-RRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLYAADVKGSLSDEDL 152
            :.|.||| ..:|.|..|:......|.|         |:.|              |. |::..|.:
  Rat   616 ETIKIQQIAMEMQLTPFLILLRKTLEQ---------LQEK--------------DT-GNIFSEPV 656

  Fly   153 DVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWH-------TEDMDLYSINYLHFG 210
            .:..:..||.:     .||   :|.:.....:|.|.::..|:.       .||.:|...|.|.:.
  Rat   657 PLSEVTELDEV-----PDY---LDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYN 713

  Fly   211 APKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEAGEIM 275
            |..|      .:.|...:|..:                    ...||||       ..::|.::.
  Rat   714 AKDT------IFYRAAVRLREQ--------------------GGAVLRQ-------ARRQAEKMG 745

  Fly   276 ITFPFGYHAGFNHGFNGAESTNF-----------------------------------ASKRWIE 305
            |.|..|.|  ..|...|.|.::.                                   |||:.:.
  Rat   746 IDFETGMH--IPHNLAGDEVSHHTEDVEEERLVLLENQKHLPVEEQLKLLLERLDEVNASKQSVG 808

  Fly   306 YGKRASICRCRSDMVKISMETFVRRFQPERYDNWLKGQDMGCHPEEPGKICAAAPPTLNEYEKQE 370
            ..:||.       |:|..|....|:.               .|..|.|:
  Rat   809 RSRRAK-------MIKKEMTALRRKL---------------AHQRETGR---------------- 835

  Fly   371 NLRAAKSEEESPQKRGCSLAGN------GCERNAESAEDVDDKASVSSYSSCRQLQP-------- 421
                     :.|::.|.|..||      .|:::.::....::.   ||..:.:.|.|
  Rat   836 ---------DGPERHGPSGRGNLTPHPAACDKDGQTDSAAEES---SSQETSKGLGPNMSSTPAH 888

  Fly   422 -------VVKLRKLPTIASVPE-PSSAPKRYDFNTEAVVRVKRLWNELPCPDRGAN------LLT 472
                   |:..:|.|..|..|: |...||    |.|:.:          .|..|.:      |..
  Rat   889 EVGRRTSVLFSKKNPKTAGPPKRPGRPPK----NRESQM----------TPSHGGSPVGPPQLPI 939

  Fly   473 NGVVKNTKRMR 483
            .|.::..||.|
  Rat   940 MGSLRQRKRGR 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	24/122 (20%)
Brpf1	XP_006237117.1	EPL1	106..254	CDD:287484
		PHD_BRPF1	266..327	CDD:277146
		ePHD_BRPF1	329..449	CDD:277171
		Bromo_brd1_like	631..734	CDD:99944	25/160 (16%)
		BR140_related	1121..1236	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900