DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and kdm4c

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001077320.1	Gene:	kdm4c / 570194	ZFINID:	ZDB-GENE-070209-38	Length:	1482	Species:	Danio rerio

Alignment Length:	428	Identity:	222/428 - (51%)
Similarity:	294/428 - (68%)	Gaps:	28/428 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ADEEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNINMT 72
            |....|...:||||||:.|||::|:.|:.|:||:|||.|||||:.||..|.||::..|||  :..
Zfish     6 ASAPANPACKIMTFRPTMEEFKDFNQYLVYMESQGAHRAGLAKVIPPKGWKPRRNYDDID--DFV 68

  Fly    73 IPAPICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISP 137
            |.|||.|:|.|..|::.|.|| |::.:|:::|...|||:::.|||:.:|:|||||||||:|::||
Zfish    69 IQAPIQQMVAGQSGLFTQYNI-QKKPLTVQEFRRLANSDMYCTPRYLNYEDLERKYWKNLTFVSP 132

  Fly   138 LYAADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLY 202
            :|.|||.|:|.|||::.||||.|:::|:::..|..:.|.||||.||||||||:||:|||||||||
Zfish   133 IYGADVSGTLYDEDIEEWNIGHLNSVLDVIEEDCGVSIQGVNTPYLYFGMWKTSFSWHTEDMDLY 197

  Fly   203 SINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKI 267
            ||||||||.||:||||||.:|:|||:||...|..:::.|.|:||||||:|||.||::::||::||
Zfish   198 SINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPNSFKSCEAFLRHKMTLISPSVLKKYSIPFDKI 262

  Fly   268 TQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQ 332
            ||||||.|||||:|||||||||||.||||||||.|||:|||.|:.|.|..|||||||:.||||||
Zfish   263 TQEAGEFMITFPYGYHAGFNHGFNCAESTNFASIRWIDYGKLATQCTCSKDMVKISMDPFVRRFQ 327

  Fly   333 PERYDNWLKGQDMGCHPEEPGKICAAAPPTLNEYEKQENLRAAKSEEES-PQKRGCS-------- 388
            |:||:.|.:|:| .|..:.    ....|.|..|.:.....|..|:...| ...|.||
Zfish   328 PDRYELWTQGKD-SCSLDH----TLPTPSTTPELQSWLQRRRRKTPSTSLHAPRSCSKRLKTVDS 387

  Fly   389 --LAGNG---------CERNAESAEDVDDKASVSSYSS 415
              :.|:|         .:...|..||.......|.|||
Zfish   388 APVKGSGRRSRSAALTAKNKEEEEEDPVKHQKESQYSS 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	25/41 (61%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	85/115 (74%)
kdm4c	NP_001077320.1	JmjN	16..57	CDD:128818	25/40 (63%)
		JmjC	177..293	CDD:202224	85/115 (74%)
		PHD_SF	1079..1176	CDD:304600
		ePHD_JMJD2C	1185..1294	CDD:277185
		TUDOR	1308..1364	CDD:197660
		TUDOR	1366..1421	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2716
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm6370
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.710