DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and KDM4D

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_060509.2	Gene:	KDM4D / 55693	HGNCID:	25498	Length:	523	Species:	Homo sapiens

Alignment Length:	453	Identity:	214/453 - (47%)
Similarity:	287/453 - (63%)	Gaps:	32/453 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTRSSFADEEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYD 65
            |.|..|.|:..||....||.|.|:.|||.:|..||.|:||:|||.||||||.||.||..|::
Human     1 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARET--- 62

  Fly    66 IDNIN-MTIPAPICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYW 129
            .|||: :.|..|:.||.:|..||:.|.: ::::.||:.::...|||:.:|||.|.:::|||||||
Human    63 YDNISEILIATPLQQVASGRAGVFTQYH-KKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYW 126

  Fly   130 KNITYISPLYAADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAW 194
            ||..|.||:|.||:.|||.||:...||:|.|.||.:|:..:..::|:||||.||||||||::|||
Human   127 KNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAW 191

  Fly   195 HTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQ 259
            ||||||||||||||.|.|||||.:||.:|:|||:||.|.|..:.:.|.|:||||:.:|||.||::
Human   192 HTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKE 256

  Fly   260 HNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISM 324
            :.||:|:|||||||.|:|||:|||||||||||.||:.|||:.|||:|||.||.|.|....|..||
Human   257 NGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSM 321

  Fly   325 ETFVRRFQPERYDNWLKGQDMG----CHPEEPGKICAAAPPTLNEYEKQENLRAAKSEEESPQKR 385
            :.|||..||||||.|.:|||..    ..|..|     |:.....:.|.|...|||....:.|...
Human   322 DAFVRILQPERYDLWKRGQDRAVVDHMEPRVP-----ASQELSTQKEVQLPRRAALGLRQLPSHW 381

  Fly   386 G-------CSLAGNGCERNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEPSSAP 441
            .       .:.:|..|.....|:  :..:::||..::    ||     :...:.|..:|||.|
Human   382 ARHSPWPMAARSGTRCHTLVCSS--LPRRSAVSGTAT----QP-----RAAAVHSSKKPSSTP 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	26/41 (63%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	79/115 (69%)
KDM4D	NP_060509.2	JmjN	19..53	CDD:280526	21/33 (64%)
		JmjC	179..295	CDD:202224	79/115 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..523		9/36 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58782
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm8529
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.790