Protein Alignment Kdm4A and KDM4D

DIOPT Version :10

• Sequence 1: NP_610331.1
• Gene: Kdm4A / 35744
• FlyBaseID: FBgn0033233
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_060509.2
• Gene: KDM4D / 55693
• HGNCID: 25498
• Length: 523
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 214/453 - (47%)
• Similarity: 287/453 - (63%)
• Gaps: 32/453 - (7%)

  Fly     1 MSTRSSFADEEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYD 65
            |.|..|.|:..||....||.|.|:.|||.:|..||.|:||:|||.||||||.||.||..|::
Human     1 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARET--- 62

  Fly    66 IDNIN-MTIPAPICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYW 129
            .|||: :.|..|:.||.:|..||:.|.: ::::.||:.::...|||:.:|||.|.:::|||||||
Human    63 YDNISEILIATPLQQVASGRAGVFTQYH-KKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYW 126

  Fly   130 KNITYISPLYAADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAW 194
            ||..|.||:|.||:.|||.||:...||:|.|.||.:|:..:..::|:||||.||||||||::|||
Human   127 KNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAW 191

  Fly   195 HTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQ 259
            ||||||||||||||.|.|||||.:||.:|:|||:||.|.|..:.:.|.|:||||:.:|||.||::
Human   192 HTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKE 256

  Fly   260 HNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISM 324
            :.||:|:|||||||.|:|||:|||||||||||.||:.|||:.|||:|||.||.|.|....|..||
Human   257 NGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSM 321

  Fly   325 ETFVRRFQPERYDNWLKGQDMG----CHPEEPGKICAAAPPTLNEYEKQENLRAAKSEEESPQKR 385
            :.|||..||||||.|.:|||..    ..|..|     |:.....:.|.|...|||....:.|...
Human   322 DAFVRILQPERYDLWKRGQDRAVVDHMEPRVP-----ASQELSTQKEVQLPRRAALGLRQLPSHW 381

  Fly   386 G-------CSLAGNGCERNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEPSSAP 441
            .       .:.:|..|.....|:  :..:::||..::    ||     :...:.|..:|||.|
Human   382 ARHSPWPMAARSGTRCHTLVCSS--LPRRSAVSGTAT----QP-----RAAAVHSSKKPSSTP 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:472837	26/41 (63%)
		JmjC	182..298	CDD:396791	79/115 (69%)
KDM4D	NP_060509.2	JmjN	18..58	CDD:128818	25/39 (64%)
		JmjC	179..295	CDD:396791	79/115 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	407..523		9/36 (25%)