DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and MLLT6

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_005928.2	Gene:	MLLT6 / 4302	HGNCID:	7138	Length:	1093	Species:	Homo sapiens

Alignment Length:	184	Identity:	45/184 - (24%)
Similarity:	62/184 - (33%)	Gaps:	40/184 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 GYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISME---TFVRRFQPE-RYDNWLK 341
            |..||...|..|...:.|.|.|           |.||.......|   |...|.|.: |.|....
Human   195 GGGAGGGGGSMGGGGSGFISGR-----------RSRSASPSTQQEKHPTHHERGQKKSRKDKERL 248

  Fly   342 GQDMGCHPEEPGKICAAAPPTL------------NEYEKQENLRAAKSEEESPQKRGC--SLAGN 392
            .|.....||.|..|  ..||.:            :.:.:......::|..||..|:..  ||:..
Human   249 KQKHKKRPESPPSI--LTPPVVPTADKVSSSASSSSHHEASTQETSESSRESKGKKSSSHSLSHK 311

  Fly   393 GCE----RNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEPSSAPK 442
            |.:    :...|.......:|.||.||....||.|.     ::.|.|:.|:.||
Human   312 GKKLSSGKGVSSFTSASSSSSSSSSSSGGPFQPAVS-----SLQSSPDFSAFPK 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	5/16 (31%)
MLLT6	NP_005928.2	PHD_AF10_AF17	7..54	CDD:277049
		ePHD_AF17	61..185	CDD:277179
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..500		45/184 (24%)
		Leucine-zipper	729..764
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	775..871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900