DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and lid

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster

Alignment Length:	441	Identity:	120/441 - (27%)
Similarity:	190/441 - (43%)	Gaps:	101/441 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PPAEWVPRKSGYDIDNINMTIPAPICQVVTGAHGVYQQINIQQ-RRQMTLRQFMEKAN---SELH 113
            |..||:                .|.| ||.......:....:| .|:.||:||.:.|:   .|..
  Fly   486 PKGEWL----------------CPRC-VVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYF 533

  Fly   114 QTPRHF-DYDDLERKYWKNITYI----SPLYAADV-----------KGSL----SDEDL--DVWN 156
            :.|.|. ..:.:||::|:.::.|    :..|.||:           |.||    .|::.  ..||
  Fly   534 RKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWN 598

  Fly   157 IGRL----DTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSINYLHFGAPKTWYA 217
            :..|    |:||..:|.|    |.|:|..::|.||..::|.||.||...|||||||:|.|||||.
  Fly   599 LNNLPLLEDSILGHINAD----ISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYG 659

  Fly   218 IPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEAGEIMITFPFGY 282
            :|.:...:.|:...:...|.:......|...:|:::|.:|..:.:|..:..|.|||.:||||..|
  Fly   660 VPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAY 724

  Fly   283 HAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPERYDNWLKGQDMGC 347
            |||||.|:|.||:.|||...|::.|:..           ::..:.:|||....:|      ::.|
  Fly   725 HAGFNQGYNFAEAVNFAPADWLKMGREC-----------VNHYSMLRRFCVFSHD------ELVC 772

  Fly   348 HPE-EPGKI-------CAAAPPTLNEYEK--QENL------RAAKSEEE--SPQKRGCSLAGNGC 394
            ... ||.|:       |......:.:.||  :::|      ||.:...|  :..:|.|......|
  Fly   773 KMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAERRAFELVNDDERHCQECNTTC 837

  Fly   395 ERNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIAS-VPEPSSAPKRY 444
            ..:|.:.| .:||.             :|.||....:.. .||..:...||
  Fly   838 FLSAVACE-CNDKL-------------IVCLRHYTVLCGCAPEKHTLIYRY 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	3/5 (60%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	47/115 (41%)
lid	NP_001245908.1	JmjN	160..201	CDD:128818
		ARID	227..312	CDD:198082
		PHD1_Lid_like	450..495	CDD:277078	4/24 (17%)
		JmjC	624..740	CDD:202224	47/115 (41%)
		zf-C5HC2	830..882	CDD:280996	13/59 (22%)
		PLU-1	896..1229	CDD:285609
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455779
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940