DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and CG15439

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_608836.1	Gene:	CG15439 / 33651	FlyBaseID:	FBgn0031606	Length:	1008	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	100/537 - (18%)
Similarity:	164/537 - (30%)	Gaps:	187/537 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RSSFADEEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDN 68
            :.:.|.|.:...|..   .|:....|.....|::..:|...|       .|..|||.:....:
  Fly   324 KEALAAEHETPAPHP---NPAQARIQRKLLKIQHKYTRHKEL-------KPTPWVPTQKMSRL-- 376

  Fly    69 INMTIPAPICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNIT 133
              :|..|..|                 ||.:...:.|......|.|...|.:.....||.|
  Fly   377 --LTTSASAC-----------------RRLLAKAEIMSVDVQHLEQREAHINALTDIRKKW---- 418

  Fly   134 YISPLYAADVKGSLSDEDLDVWNIGRLDTILN----------LVNTDYNIIIDGVNTAYLYFGMW 188
            :|:|.::.:......|      .|.|:|....          :::.|.:::....:||     :.
  Fly   419 HIAPAFSVEFTAYYMD------RIVRMDDFRQQQRELISHNAILSKDQDVLRAQYDTA-----LE 472

  Fly   189 KSSFAWHTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMIS 253
            :......|:|..|.||..||           .|.|:....:...:..        .:.|.:....
  Fly   473 ERKAVKATKDSLLTSIKSLH-----------TALGQIAPNMTLPSVD--------LIAHPLPEAP 518

  Fly   254 PKV------LRQHNIPYNKITQEAGEIMITFPFGYHAG------------FNHGFNGAESTNFAS 300
            ||.      .|..::|    |..|.::.:.||.| |.|            ..|...|..||:.||
  Fly   519 PKTSTPTPPQRPISVP----TAAALKMGVGFPLG-HLGPPGSKMDSSRMLSTHAKQGKHSTSSAS 578

  Fly   301 KRWIEYGKRAS--IC-RCRSDMVKISMETFVRRFQPERYDNWLKGQDMGCHPEEPGKICAAAPPT 362
               :|.....|  || |.:...:.:..:|....:.            :||           ..|.
  Fly   579 ---VEAAPSVSCGICKRSKDQHLLVKCDTCNLHYH------------LGC-----------LNPP 617

  Fly   363 LNEYEKQENLRAAKSEEESPQKRGCSLAGNGCERNAESAEDVDDKAS-----------------V 410
            |....|       ||::...|...|      |:: :|.::.|.:.:|                 |
  Fly   618 LTRPPK-------KSKQYGWQCSEC------CDK-SEGSDAVTEISSGPRKSRTRFNKDGHLVYV 668

  Fly   411 SSYSSCRQLQPVVKLRKLPTIA-SVPEPSSAPKRYDFNTEAVVRVKRLWNE-LPCPDRGANLLTN 473
            ..||          |..:|..| :||:.|              ..||..|: ||.|   |.....
  Fly   669 DRYS----------LDDIPVAAVNVPKES--------------HTKRALNKSLPAP---APEYIE 706

  Fly   474 GVVKNTKRMRFQTKVLT 490
            .:.|:.||.:.|:...|
  Fly   707 DLTKSPKRPKLQSPCKT 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	7/41 (17%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	25/133 (19%)
CG15439	NP_608836.1	PHD1_PHF14	120..175	CDD:277036
		ePHD_PHF14	184..297	CDD:277144
		PHD2_PHF14	586..635	CDD:277037	13/78 (17%)
		PHD3_PHF14	949..997	CDD:277038
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900