DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and kdm4ab

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_001339664.2	Gene:	kdm4ab / 334347	ZFINID:	ZDB-GENE-030131-6279	Length:	1045	Species:	Danio rerio

Alignment Length:	501	Identity:	237/501 - (47%)
Similarity:	313/501 - (62%)	Gaps:	81/501 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNINMTIPAPICQVVT 82
            ||||.|:.|||:|||.||.|:||:|||.||||||.||..|.||.|..|||  ::.|||||.||||
Zfish    11 IMTFHPTVEEFKNFSRYIAYMESQGAHKAGLAKIVPPKNWKPRGSYDDID--DLIIPAPIQQVVT 73

  Fly    83 GAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLYAADVKGSL 147
            |..|::.|.|| |::.||:::|.:.|||:...:||:.|:::||||||||:|:..|:|.|||.|:|
Zfish    74 GQSGLFTQYNI-QKKAMTVKEFRKTANSDKFCSPRYDDFEELERKYWKNVTFNPPIYGADVNGTL 137

  Fly   148 SDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSINYLHFGAP 212
            .|.|:..||:|.|:|||:.|..:..|.|:||||.||||||||::|||||||||||||||||||.|
Zfish   138 YDPDIKEWNVGHLNTILDTVEHESGITIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEP 202

  Fly   213 KTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEAGEIMIT 277
            |:||.:||.:|:|||:||...|..:.|.|.|:||||||:|||.:|:::.||:.||||||||.|:|
Zfish   203 KSWYTVPPEHGKRLERLAKGFFPGSSQNCEAFLRHKMTLISPSILKKYGIPFEKITQEAGEFMVT 267

  Fly   278 FPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPERYDNWLKG 342
            ||:|||||||||||.|||||||::|||:|||:|.:|.||.|||||||:.||::||||||:.||:|
Zfish   268 FPYGYHAGFNHGFNCAESTNFATRRWIDYGKQAILCSCRKDMVKISMDVFVKKFQPERYELWLEG 332

  Fly   343 QDMG--CH----PE-------EPG----------------------------KICAAAP-PTLNE 365
            :|..  .|    ||       |.|                            ::|...| ..|.:
Zfish   333 KDNAPIDHSKPTPEAAEFLGGEAGAQELRIENQSNEGQKKSLAKQRIGTKRHRVCLDFPEEVLPK 397

  Fly   366 YEKQENLRAAKSEEESPQKRGCS-------------LAGNGC------ERNAESAE--------- 402
            .|..:.....|....:|....|.             |.|:..      .|:||.:|
Zfish   398 TETNDEAEYGKKGRLTPYTEQCKEYTELKHEDRTLPLMGSTSLKMLPGSRSAEFSENVRGAGFSD 462

  Fly   403 -DVDDKASVSSYSSCRQLQPV--VKLRKLPTI----ASVPEPSSAP 441
             |:|.||: |..|:|.|..|.  :.:..:||:    ::||..|:.|
Zfish   463 ADLDAKAT-SHISACAQPFPKHHLSIASVPTVPHCLSAVPRVSTKP 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	28/40 (70%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	82/115 (71%)
kdm4ab	XP_001339664.2	JmjN	10..52	CDD:128818	28/40 (70%)
		JmjC	172..288	CDD:202224	82/115 (71%)
		PHD_SF	654..746	CDD:304600
		ePHD_JMJD2A	755..864	CDD:277183
		TUDOR	879..932	CDD:197660
		TUDOR	936..991	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578736
Domainoid	1	1.000	212	1.000	Domainoid score	I2716
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm6370
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.740