DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and jade1

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_956099.1	Gene:	jade1 / 327437	ZFINID:	ZDB-GENE-030131-5648	Length:	829	Species:	Danio rerio

Alignment Length:	294	Identity:	44/294 - (14%)
Similarity:	86/294 - (29%)	Gaps:	131/294 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 LEKLANETFSENYQECNAYLRHKMTMI---------SPKVLRQHNIPYNKITQEAGEIMITF--- 278
            ||::.|.|:..:.:|     |.|.|:.         ..::|.|..:.....|:...|.|..|
Zfish   496 LERVRNLTYMVSRRE-----RIKRTLCRVQEQIFHHHVRLLEQGRVTGVSSTRRLEEAMFYFRTT 555

  Fly   279 --------PFGYHAGFNHGFNGAE--STNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQP 333
                    |...|.|.|...:.:|  |.::.|.:.||
Zfish   556 PPVPASPQPLKGHCGQNSTLSSSEKGSNSYRSSKHIE---------------------------- 592

  Fly   334 ERYDNWLKGQDMGCHPEEPGKICAAAPPTLNEYEKQENLRAAKSEEESPQKRGCSLAGNGCERNA 398
                           .::|.|:.....|:..:..:.|.:.:|.|.    :..|.:.:|....:..
Zfish   593 ---------------ADKPAKMLMDGVPSSGDSVRSETVMSASSR----RSEGRTRSGESHRKEE 638

  Fly   399 ESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEPSSAPKRYDFNTEAVVRVKRLWNELPC 463
            ||...::|:.                                            |..:||:::..
Zfish   639 ESERPLEDRR--------------------------------------------RKSKLWDQVSI 659

  Fly   464 PDRGANLLTNGVVKNTKRMR----FQTKVLTLDD 493
            .|:         :::.|.|.    .:|::.|:||
Zfish   660 KDK---------LRHAKSMEDTLSSETELDTMDD 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	20/93 (22%)
jade1	NP_956099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		EPL1	<104..173	CDD:287484
		PHD_JADE1	198..243	CDD:277149
		ePHD_JADE	251..361	CDD:277141
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..408
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..651		21/185 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900