DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and Kdm4b

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001037701.2	Gene:	Kdm4b / 301128	RGDID:	1588576	Length:	1099	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	243/513 - (47%)
Similarity:	323/513 - (62%)	Gaps:	81/513 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNINMTIPAP 76
            ||...:||||||:.:||::|:.|:.||||:|||.||||||.||.||.||::..|||::  .||||
  Rat     9 QNPSCKIMTFRPTMDEFRDFNRYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDV--VIPAP 71

  Fly    77 ICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLYAA 141
            |.|||||..|::.|.|| |::.||:.::...||||.:.||||.|:||||||||||:|::||:|.|
  Rat    72 IQQVVTGQSGLFTQYNI-QKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGA 135

  Fly   142 DVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSINY 206
            |:.|||.|:|:..||||.|.:||::|..:...||:||||.||||||||::|||||||||||||||
  Rat   136 DISGSLYDDDVAQWNIGNLRSILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINY 200

  Fly   207 LHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEA 271
            ||||.||:||||||.:|:|||:||...|..:.|.|:|:||||||:|||.:|:::.||:::|||||
  Rat   201 LHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEA 265

  Fly   272 GEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPERY 336
            ||.|||||:|||||||||||.|||||||:.|||:|||.|:.|.||.|||||||:.|||..|||||
  Rat   266 GEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERY 330

  Fly   337 DNWLKGQDMGC--HPEEPGKICAAAPPTLNEYE-KQENLRA---------------AKSEEE--- 380
            :.|.:|:|:..  |.    :..|.:.|.|:.:. .:.:|:|               .|:|||
  Rat   331 EQWKQGRDLTVLDHT----RPTALSSPELSSWSASRTSLKAKLLRRQISVKESRPWRKAEEERRP 391

  Fly   381 --------------------------------SPQKRGCSLAG----NGCERNAESAEDVDDKAS 409
                                            ||.:....:||    .||.|.....|:.:::.
  Rat   392 SLERRREPTRRPGPASHRRRSQPKKSKPEDSRSPGEATAGVAGLDEARGCSRRETMPEEEEEEE- 455

  Fly   410 VSSYSSCRQLQPV----------VKLR---KLPTIASVPEPSSAPKRYDFNTEAVVRV 454
             .|.|...:.:.|          .|.|   |.|::.|.|..|:.|..  |..|.|:|:
  Rat   456 -LSPSQGHEAEGVEEDGRGKPRPTKARSKKKTPSLLSPPLLSAPPAL--FPAEEVLRL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	27/41 (66%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	84/115 (73%)
Kdm4b	NP_001037701.2	JmjN	15..56	CDD:128818	27/40 (68%)
		JmjC	176..292	CDD:396791	84/115 (73%)
		AvrE	475..>671	CDD:338078	12/38 (32%)
		PHD_SF	686..789	CDD:419867
		ePHD_JMJD2B	798..907	CDD:277184
		Tudor_JMJD2B_rpt1	920..973	CDD:410535
		Tudor_SF	977..1032	CDD:413384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2717
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H27773
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm9003
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.720